Local officials the Democratic Republic of the Congo on Sunday updated reporters on the Bundibugyo Ebola virus outbreak there, which has caused the WHO to declare it a health emergency of international concern and the United States to enacte travel restrictions. Photo by Marie Jeanne Munyerenkana/EPA

May 18 (UPI) — The U.S. Centers for Disease Control and Prevention on Monday restricted non-U.S. passport holders from entering the United States if they have been in Uganda, the Democratic Republic of the Congo or South Sudan in the past 21 days.

The agency made the announcement as there have at least 346 cases and 88 deaths in the DRC, on top of several cases that have been confirmed in nearby nations in people who been there, the CDC said over the weekend.

The CDC said that is coordinating with various agencies and companies to manage travelers who have been exposed to Ebola as it also deploys employees to support containment of the outbreak in the three nations.

“CDC assess the immediate risk to the general U.S. public as low, but we will continue to evaluate the evolving situation and may adjust public health measures as additional information becomes available,” the agency said in a situation summary.

In the last five days, the World Health Organization confirmed that the Ebola virus circulating in the three countries right now is the Bundibuyo virus, one of four known strains that have affected humans since Ebola was discovered in mid-1970s.

Although there is an approved, licensed vaccine against Ebola which has successfully been used to quell outbreaks, the vaccine — called Ervebo — only protects against acquisition of the Zaire species of Ebola virus, making it useless in the current outbreak, according to the CDC.

WHO on Saturday declared the outbreak a public health emergency of international concern.

In its update, WHO said that there are “significant uncertainties to the true number of infected persons and geographic spread associated with this event at the present time. In addition, there is limited understanding of the epidemiologic links with known or suspected cases.”

Ebola spreads from wild animals to humans and from human to human through direct contact with blood or other bodily fluids from infected individuals, and carries a case fatality rate of roughly 50%.

A number of affected Americans have reportedly been exposed to the virus during the outbreak.

The CDC has recommended that people who have traveled through the two countries in the last 21 days should immediately seek medical attention if they develop Ebola symptoms, which can include fever, weakness, vomiting, diarrhea or unexplained bleeding.

In addition to roughly 30 CDC employees dispatched to the region, and will join officials from several other global and regional health agencies, the WHO is expected to convene an emergency committee to advise the agency’s director-general on its response the outbreak.

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