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Diane Ladd’s cause of death has come to light, weeks after the three-time Oscar-nominated “Rambling Rose” and “Wild at Heart” star died at age 89.

The actor died of “acute on chronic hypoxic respiratory failure,” according to her death certificate obtained by People. The Cleveland Clinic says the condition is a result of insufficient oxygen in a person’s blood and is commonly caused by heart and lung conditions.

The death certificate reportedly notes that Ladd had the latter. Two years before her death, Ladd was diagnosed with idiopathic pulmonary fibrosis, a disease wherein “lung tissue becomes damaged and scarred,” according to the Mayo Clinic. Esophageal dysmotility —disorders that affect the esophagus’ ability to move food and liquid to a person’s stomach — also contributed to Ladd’s death, People reported.

Ladd was cremated on Nov. 10, a week after her death, the death certificate reportedly said.

Laura Dern, Ladd’s daughter with prolific Oscar-nominated actor Bruce Dern, announced her mother’s death Nov. 3: “My amazing hero and my profound gift of a mother, Diane Ladd, passed with me beside her this morning, at her home in Ojai.”

“She was the greatest daughter, mother, grandmother, actress, artist and empathetic spirit that only dreams could have seemingly created,” Dern, Oscar-winning star of “Marriage Story,” said in her statement. “We were blessed to have her.”

Bruce Dern, the first of Ladd’s three husbands, praised his ex-wife for her work on- and off-screen, including her longtime tenure as a Screen Actors Guild board member.

“She was a great teammate to her fellow actors. She was funny, clever, gracious,” he said. “But most importantly to me, she was a wonderful mother to our incredible wunderkind daughter. And for that I will be forever grateful to her.”

Mississippi native Ladd was an enduring talent whose screen career included more than 200 movie and TV credits from the 1960s to the 2020s, and multiple Emmy and Oscar nominations. Famously, she appeared in director Martin Scorsese and writer Robert Getchell’s 1974 feature “Alice Doesn’t Live Here Anymore,” originating the role of snarky roadside-diner waitress Florence Jean “Flo” Castleberry.

When Ladd was diagnosed with idiopathic pulmonary fibrosis in 2023, she was told she might have only six months to live. This inspired Laura Dern to take her mother out for strolls along Santa Monica, sparking intimate conversations that would become fodder for their joint book, “Honey, Baby, Mine,” released in April 2023.

“All the deep listening filled us with love,” Ladd told People amid the book’s release. “And it was very healing.”

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