Wu made a scintillating start to the evening, having resumed at 4-4 after an afternoon session that was briefly interrupted by a female spectator jumping over the front-row barrier before referee Rob Spencer and security intervened to remove her.
Breaks of 82 and 103 gave him a two-frame advantage and while Murphy, who had earlier recovered from 3-0 down, hit back with a 72 it appeared as though he was struggling to stem the flow of his opponent.
Murphy, 43, who is aiming to set a new record for the longest gap between first and second titles, openly admitted that Wu had blasted him off the table at the Masters in January – albeit in a best-of-11 contest.
And having never won a match on his two visits to the Crucible prior to this year, Wu has so far has answered every question posed of him in the longer format.