december

Exelixis outlines December PDUFA timeline for ZANZA CRC filing while adding $750M buyback authorization (NASDAQ:EXEL)

Earnings Call Insights: Exelixis (EXEL) Q1 2026

Management View

  • Michael Morrissey (CEO, President & Director) said the company’s strategy is “to build a multi-franchise business in solid tumor oncology focused on GU and GI histologies,” anchored by cabozantinib and “the potential breadth of the zanzalitinib opportunity,” and added that “CABOMETYX

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The Wallis Annenberg Wildlife Crossing to open this December

Right-wing pundits and politicos recently attacked the gargantuan wildlife crossing being constructed over the 101 Freeway in Agoura Hills over ballooning costs and delays.

A March 18 post in an outlet published by a conservative think tank set the outrage in motion, calling the now $114-million project a “bridge to nowhere” and “jobs program for environmentalists.” The Murdoch-owned California Post republished it and social media lit up. In an X post, U.S. Transportation Secretary Sean Duffy compared it with the state’s long-delayed, budget-busting high-speed train.

In short, they painted it as a boondoggle. One that might never get done.

But now the Wallis Annenberg Wildlife Crossing has a completion date: Dec. 2, announced at an Earth Day news conference held on the structure rising over a 10-lane stretch of the freeway. Cars whizzed by below.

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That’s when the ribbon will be cut and mountain lions suffering from a lack of genetic diversity are expected to get their ticket out of the freeway-locked Santa Monica Mountains to seek mates elsewhere. Lions there have already shown alarming signs of inbreeding, including kinked tails and deformed testicles. The population could go extinct without intervention, and state wildlife officials listed the pumas as threatened earlier this year.

“This is a visionary project that was the impossible dream,” said Beth Pratt, California regional executive director with the National Wildlife Federation and the public face of the crossing. “This is something that’s captured the imagination of Angelenos, captured the imagination of the world.”

Driving under the crossing feels unremarkable; just another concrete behemoth. But it’s another world on top. Under a blue sky and puffy clouds, a gentle wind blew through a sea of about 6,000 native plants — Santa Barbara milk vetch, golden yarrow and purple sage.

It melts into the surroundings — and that’s the point. Soil that was hauled in was inoculated with the same microbes and mycorrhizal fungi that thrive in the nearby hills. The plants were grown just for the crossing, with another 40,000 on the way.

Miguel Ordeñana, senior manager of community science at L.A. County’s Natural History Museum, who discovered the late, great mountain lion P-22 in Griffith Park, saw the whole thing unfold.

Standing atop the suspended habitat, he envisioned bobcats hiding behind the bushes and ambushing ground squirrels: “I can see it now as this thing is coming to life.”

The event drew representatives from Caltrans, National Park Service, Santa Monica Mountains Conservancy, Agoura Hills City Council and other partners.

A photo of P-22 taken in the very early morning on Dec.19, 2016 in Griffith Park.

The plight of P-22, a celebrity mountain lion that once inhabited Griffith Park, helped inspire the wildlife crossing being built over the 101 Freeway in Agoura Hills

(Miguel Ordeñana)

There’s still significant work to be done before bobcats can come aboard.

Crews are currently building a second overpass over Agoura Road.

Once that’s completed over the summer, they’ll haul in 3 million cubic feet of soil — enough to fill half of SoFi Stadium — to bridge the gap between the two structures. Berms will be constructed to block out noise and light.

Like many dreams in California, the project didn’t come cheap. When it broke ground in 2022, it was expected to cost nearly $93 million. That held until last spring, when bids for the second stage of the project went out and “came back through-the-roof high,” Pratt told The Times earlier this year. The current estimate is $114 million but could potentially top out several million higher.

The surge came amid inflation and tariff-driven price increases. The National Highway Construction Cost Index, a figure calculated by the Federal Highway Administration, has increased by 67% since 2021. Torrential rains in 2022 and 2023 delayed the completion by a year.

There’s also the scale: It’s the largest wildlife crossing in the world, with two structures that together span roughly 320 by 175 feet.

The effort appears to be paying off. Driving down to L.A. earlier this month, Pratt was distressed because she was hitting painted lady butterflies in the midst of their long-distance migration. When she ascended the crossing the following day, she saw the dainty orange, black and white insects fluttering about. It moved her to tears.

They weren’t the only lepidoptera. American lady butterflies were laying eggs and white-lined sphinx moth caterpillars were inching along plants.

Then there’s Bob, a western fence lizard that’s taken up residence at the top of stairs that lead to the crossing. A rattlesnake has claimed the bottom. Birds like yellow-rumped warblers and California scrub jays round out the initial cast.

“I can say with some certainty that this is going to be the most popular reality show that L.A. produces,” Pratt said. Cameras will capture the action, though it won’t be broadcast live because “this is L.A. and someone will go try to pet the mountain lions.”

L.A. deserves a good show. The region is reeling from devastating wildfires, immigration raids and the upending of the state governor’s race. County residents reported record-low quality of life in a UCLA survey this year, with the high cost of living looming large.

Much is uncertain, uneasy. The soon-to-open crossing offers one non-abstract finish line.

More recent wildlife news

California lawmakers are considering a bill to create a statewide program to promote coexistence between people and wildlife, an issue reinvigorated by the euthanization of a beloved black bear with two cubs in Monrovia, writes Times reporter Katie King. The state’s wildlife agency operated a similar program until two years ago, when funding ran dry.

A bear wanders across a porch.

Blondie the bear wanders across a porch in Monrovia. The mama bear was euthanized by the California Department of Fish and Wildlife following two incidents where she swiped at residents.

(Brian Gordon)

The Golden State expanded the area in which boats are asked to slow down in an effort to avoid hitting and killing whales, reports the San Francisco Chronicle’s Brooke Park. Ship strikes are a leading cause of death for several whale species off California, where some of the world’s largest cargo ships pass through key feeding and migration routes.

Nutria, a hefty rodent with the tail of a rat, reappeared in California in 2017 — close to 40 years after it was deemed eradicated. As my colleague Samantha Lee explains, California wildlife officials recently published a study indicating the animal — considered a pest — was deliberately brought back to the state.

A few last things in climate news

California is in the midst of a powerful late-season storm, bringing significant rain to northern regions of the state. However, as fellow Times writer Ian James broke down, the state experienced the hottest March on record — a phenomenon that prematurely melted snow in the Sierra Nevada. The heat and early melt is expected to dry out forests earlier than normal, increasing the risk of wildfires.

After years of debate between fire officials arguing for the removal of anything that can burn within the first five feet of homes and ecologists backing selective landscaping, California proposed a compromise, reports my colleague Noah Haggerty. New regulations create a strict one-foot “Safety Zone” around homes where nothing burnable is allowed, while permitting some spaced-out plants beyond it.

Some who lost their homes in the Eaton and Palisades fires are rebuilding all-electric due to health and climate concerns. Per Times staffer Blanca Begert, burning gas and propane for cooking, as well as water and space heating, in California homes and businesses creates 10% of the state’s greenhouse gas emissions.

One last thing

A black-furred wolf that visited L.A. County before making her way to the Eastern Sierra.

BEY03F, the wolf pictured, briefly visited L.A. County before making her way to the Eastern Sierra.

(California Department of Fish and Wildlife)

Remember the wolf that stunned everyone by visiting Los Angeles County? She made history again by venturing into Inyo County earlier this month and remains in the Eastern Sierra. Experts believe she’s probably still looking for a mate.

This is the latest edition of Boiling Point, a newsletter about climate change and the environment in the American West. Sign up here to get it in your inbox. And listen to our Boiling Point podcast here.

For more wildlife and outdoors news, follow Lila Seidman at @lila_seidman on X and @lilaseidman.bsky.social on Bluesky.

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Chris Paul’s pointed reaction to Clippers’ play-in loss to Warriors

Four months after being pushed into retirement by the Clippers, future Hall of Famer Chris Paul apparently took delight in the team’s quick exit from the postseason Wednesday night.

Paul posted the familiar meme “stopped by my biggest hater’s funeral” on his Instagram story shortly after the Clippers blew a 13-point fourth-quarter lead in a 126-121 play-in loss to the Golden State Warriors.

Paul, the Clippers’ all-time assists leader, called out teammates, coaches and executives during his short second stint with the team early this season. In an effort to inject accountability during the team’s 6-21 start, Paul instead angered many, including head coach Tyronn Lue, who wasn’t on speaking terms with Paul at the end.

“Everyone was fed up,” a league source told The Times in December.

Paul, who is second to John Stockton in NBA career assists with 12,552, posted at the time about his being cut on social media, saying “Just Found Out I’m Being Sent Home,” along with a peace emoji.

For their part, the Clippers turned around their season, going 36-19 after a horrific start to finish with a winning record for the 15th consecutive season at 42-40.

Then came the dispiriting loss to the Warriors and the 40-year-old Paul’s opportunity to get in the last meme, even though it wasn’t exactly original. Philadelphia 76ers star Joel Embiid posted the same one when the team traded guard Ben Simmons in 2022.



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Hailee Steinfeld, Josh Allen welcome a baby girl: ‘Blessed’

Hailee Steinfeld and Josh Allen have officially entered parenthood, welcoming their first little one.

“Our baby girl has arrived,” Oscar-nominated “True Grit” and “Sinners” star Steinfeld, 29, announced Tuesday in her latest Substack post. She wrote that she and her Buffalo Bills quarterback husband, 29, are “feeling incredibly grateful and blessed.”

“Savouring these early moments,” Steinfeld continued. “Thank you so much for the love and well wishes.”

The spouses married in June after two years of dating. People published photos from their outdoor California ceremony, in which Steinfeld wore a white strapless gown, mesh gloves and her veil and Allen wore a traditional tuxedo. They announced their engagement in November 2024.

Steinfeld announced she and Allen were expecting their first child in a Substack post in December, sharing photos from a snowy, bump-revealing maternity shoot. Steinfeld flaunted her pregnancy during the awards circuit earlier this year, cradling her baby bump at the red carpet for the Golden Globe Awards.

In an interview with Variety published in October, “Spider-Verse” star Steinfeld spoke about her marriage with Allen and balancing their conflicting schedules, noting “when the [NFL] offseason rolls around, it’s go-time for me.”

“I’ve gotten a lot better at understanding what it means to slow down and to share that with someone,” she said. “That’s the greatest thing ever.”



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Spice Girl revealed as a massive fan of Simon Cowell’s next big boyband December 10

THEY have amassed a legion of teen followers after becoming the next big boyband.

But it seems December 10 have also managed to make a fan out of Spice Girl Geri Halliwel.

December 10 managed to make a fan out of Spice Girl Geri HalliwelCredit: instagram/december10
Geri joins December 10 at rehearsalCredit: Supplied

This week, Biz on Sunday’s Emily caught up with the lads — Cruz, Danny, Hendrick, Sean, John, Josh and Nicolas — following the release of their latest single, Angel.

They revealed they were starstruck when Ginger Spice popped into their rehearsal at a West London studio last month, accompanied by her husband Christian Horner’s daughter.

Asked about their celebrity fans, Danny said: “The legend that is Geri Halliwell and her step-daughter came to the rehearsal studio to watch our set. They had wanted to come to our London show, but were due to be away when it was on, so we invited them to our rehearsals.

“Geri was like a pocket rocket. Petite and loads of personality.

SOUR GRAPES

X Factor star takes swipe at Simon Cowell’s boyband December 10 after Brits


TEN OUT OF TEN

December 10 backed by Brit pop star who is secretly guiding their career

“We couldn’t believe we met a Spice Girl!

“She gave excellent advice, including to always enjoy the moment.

“Geri was super kind and gave us all a bag of gifts, including little speakers we always use on our phones.”

Sean said: “She showed up to rehearsals before the show and gave us advice. She’s really cool.”

Hendrik added: “The advice that she gave was, ‘That laugh that you have in your band as a group — try and keep that laugh and enjoy it’.

“That was the main advice that came across.”

December 10 found fame on Simon Cowell’s Netflix show The Next Act last year and have amassed millions of followers on social media.

Last month, they attended their first Brit Awards, in Manchester, and have told how they brushed shoulders with singers Lola Young and Sam Fender, as well as Happy Mondays maracas player Bez.

Cruz said: “I was partying with Bez in the DJ booth — he is funny. He and I have got to go to Ibiza one day.”

To celebrate Mother’s Day, the boys have been treating their mums after receiving their first big pay cheque.

Hendrik said: “I have been saving money to try and finish my mum and dad’s house. They have been wanting to finish it for years.”

Despite the global stardom that awaits, it sounds like the boys are keeping their feet on the ground.

SIMON ‘PROUD’ OF LADS

DECEMBER 10 have revealed how their mentor Simon Cowell was proud of them after their sold-out London show.

The music mogul and his fiancee Lauren Silverman attended their gig at the O2 Academy Islington, in North London, last month.

December 10 have revealed how their mentor Simon Cowell was proud of them after their sold-out London showCredit: Getty

Band member Nicolas said: “He really enjoyed that we incorporated instruments into the live show, and when he spoke to us, that was one of the main things that made him really happy and proud.”

John added: “He has also always said that he just wants great songs. Over the past few months that we have been recording music, we have been working towards that.”

And the boys reckon it still feels surreal seeing thousands of teenagers queuing to hear them play.

Nicolas said: “I wouldn’t say it’s overwhelming, it’s more of a strange feeling, because the first show was a bit of a shock.

“It is a feeling for me, personally, that I don’t think I will get used to.”

WIN A SIGNED T-SHIRT

DECEMBER 10 have signed a T-shirt exclusively for one lucky Biz on Sunday reader.

For your chance to win the prize, email sunday features @the-sun. co.uk by March 26.

For T&Cs, visit thesun.co.uk.

HE HAZ TO SEE MATES

HE is one of the biggest pop stars on the planet, but Harry Styles says he had to change his mindset so he did not become a recluse.

He explained: “When you shut out a lot of the things that are assumed can be negative, you also just unconsciously shut out a ton of positive things.

Harry Styles says he had to change his mindset so he did not become a recluseCredit: Getty

“It can be hard to go to a bar and hang out with friends because there’s maybe people who would act [in a certain] way.

“There’s also incredible people that you can meet in that bar – that you also shut yourself off from.”

He added on SiriusXM: “I was having some experiences where I was meeting some really great people that were kind of really planting the seed of, like, ‘Oh, I don’t want to shut myself off from this world’.”

It comes as his record Kiss All The Time. Disco, Occasionally has topped the albums chart, while his track American Girls is No1 in the singles rundown.

Meanwhile, Harry’s singles Aperture and Ready, Steady, Go! are also top five.

It is truly Harry’s year.

DENISE GOES BIG

DENISE VAN OUTEN and Johnny Vaughan are creating a new Big Breakfast-style TV show 25 years after the original was axed.

I can reveal the pair, who presented the Channel 4 show in the Nineties, are working on a new format set to shake up TV schedules.

Denise said: “In my new touring show [An Evening With Denise], of all the things I’ve done, The Big Breakfast section gets the biggest reaction. I think people are still craving that chaos and the fun – we’ve lost it.”

She added: “I’m working on something with Johnny, it’s going to have that feel to it. It’s all come from the show and speaking to people. I was like, ‘Oh, people are missing this, they want this’.”

I cannot wait.

YOU’RE SO ROUGE, CHRISTINA

CHRISTINA AGUILERA was red hot on stage in this basque and matching gloves.

The US hitmaker teamed them with thigh-skimming black boots in Austin, Texas, as she headlined the Coca-Cola Sips & Sounds Music Festival.

Christina Aguilera was red hot on stage in this basque and matching glovesCredit: Shutterstock Editorial

Highlights included a performance of her 2001 hit Lady Marmalade, from film Moulin Rouge!, as fireworks lit up the sky.

MAYA’S VILLA TO VILLAIN

MAYA JAMA has revealed what her dream movie role would be – and it’s not what you might expect.

The Love Island host, who is set to star in the second series of Guy Ritchie’s Netflix crime-comedy The Gentlemen, said: “I’ve always said I don’t want to be what people expect me to be on camera.

Maya Jama has revealed what her dream movie role would be – and it’s not what you might expectCredit: Getty

“I’d want to be the complete opposite to that . . . so a monster or a mean, evil person. A villain maybe would be nice.”

DIVORCE NO2 FOR MILLIE

MADE In Chelsea couple Millie Mackintosh and Hugo Taylor have filed for divorce, I can reveal.

The pair, who married in 2018, have both appointed legal teams and have quietly started proceedings.

Millie Mackintosh and Hugo Taylor have filed for divorceCredit: Getty

Reality star turned author Millie, who has two daughters with entrepreneur Hugo, has been through the process before, having split from rapper Professor Green, who she was married to from 2013 to 2016.

A pal said: “Fans will be sad to hear that their relationship is really over, but the pair just want a clean break.

“Millie and Hugo are committed to co-parenting their two young children and keeping everything stable. They are still very amicable with each other and have a lot of respect for one another.

“They want the divorce to go through as painlessly as possible and are focusing on work in the meantime.”

Professor Green has a son with model and actress Karima McAdams, who he dated for five years after splitting with Millie.

Now, he is back in touch with Millie and said: “There’s no resentment in me. She is gorgeous. We were not good for each other at that time.

“We spoke about our mutual diagnosis (ADHD) and our kids.”

MOLLY AND TOM IN SPANISH LOVE AISLE

THEY met on Love Island: All Stars in South Africa, but Molly Smith and Tom Clare are set to tie the knot in Majorca – home of the original dating show’s villa.

The couple are eyeing up Son Marroig, a stunning, 17th century, clifftop temple on the Spanish island for their summer nuptials.

Molly Smith and Tom Clare are set to tie the knot in Majorca – home of the original dating show’s villaCredit: Supplied

The venue is popular among celebrities, with Pixie Geldof, weatherman Alex Beresford and Man City defender Nathan Ake all having held their ceremonies there.

A source said: “Majorca is a stunning destination for a wedding and there is plenty of privacy on the island. Many of the buildings are difficult to access by road and it has a secluded feel.

“There is guaranteed sun and it offers a beautiful backdrop with the most stunning sunsets.”

Tom and Molly do a weekly podcast called NearlyWeds and post regular vlogs about their planning.

Congrats guys . . . 

EX-PM SNAPS GEM OF A SHOT

GEMMA COLLINS posed with an unlikely fan at the Cheltenham races this week – as I am told that former PM David Cameron asked for a photo.

And reality favourite Gemma was only too happy to oblige David and wife Samantha in the Royal Box.

Gemma Collins with David and Samantha Cameron at the Cheltenham racesCredit: Gemma Collins/Instagram

A source said: “Gemma was honoured that David asked her for a picture. They chatted about politics and her fondness of current Conservative leader Kemi Badenoch.”

Chuffed Gemma quickly shared the snap with her 2.2million Instagram followers.

She wrote: “It was lovely to be in the Royal Box and have a good chat with David Cameron and his lovely wife. We spoke politics and . . . what we were going to bet on next.”

Gemma, who is a face of bookmaker Paddy Power, won a mighty impressive £20,000 at Cheltenham – and £5,000 off just one bet.

The GC was spotted shouting, “I’m loaded” as she basked in her glory alongside stars including Danny Dyer and Peter Crouch.

Next year, I am asking Gemma for tips.

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