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Voters approve Prop. 38 medical research bond measure

California voters have passed Proposition 38, authorizing the state to issue $8.4 billion in bonds to fund immunology and immunotherapy research aimed at curing and preventing certain chronic diseases.

The measure, which the Associated Press called on Monday evening, requires at least $4.2 billion of the funds to be used for immunology research on cancer, heart disease and Alzheimer’s disease. It also authorizes the state to enter into a partnership with an unnamed immunology and immunotherapy research institute selected by the California Department of Public Health, and to allocate half of the bond revenue to it.

Opponents argued that the measure would saddle taxpayers with decades of debt and that the requirements to qualify for grants created such a narrow pool of candidates that only one research institute in California, the California Institute for Immunology and Immunotherapy, currently meets the criteria to receive half the bond revenue. Gary K. Michelson, a wealthy philanthropist who wrote the proposition, co-founded the institute. He was also the proposition’s largest supporter, pouring $45 million into the campaign, according to state data.

Remaining funds will be used for competitive research grants that focus on immunology and immunotherapy. Those grants would be awarded by a council of representatives from University of California campuses, universities and nonprofit research institutions.

Supporters celebrated the passage on Monday saying in a press release that it “comes as federal research funding cuts have disrupted clinical trials and delayed medical discoveries nationwide.”

“This victory belongs to the patients and families who have spent years fighting devastating diseases and waiting for the next medical breakthrough,” Chris Tarver, a nurse and president of the American Nurses Association\California, said in a prepared statement.

Californians will take on an increased cost of $500 million to $600 million annually to repay the bond for an anticipated 20 years, according to the Legislative Analyst’s Office. Some or all of the cost could be offset if any funded research generates revenue. However, it’s difficult to predict how many, if any, research projects would lead to marketable treatments.

Times staff writer Hannah Fry contributed to this report.

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Multiple California ballot measures remain undecided

The fate of multiple high-stakes California ballot propositions remained undecided Wednesday, as poll workers continued to tally votes from across the state.

Other measures have generated decisive action from voters on such issues as public funding for housing and voter identification.

Six races have been called by the Associated Press, according to The Times tracker. They include four propositions — 1, 2, 3 and 37 — and two failed measures — 39 and 44. Eight remained undecided.

So far, there have been no big surprises, said Mark Baldassare, statewide survey director at the Public Policy Institute of California. The verdicts are “consistent with what we were seeing in the preelection polling.”

Undecided

Among the undecided items is Proposition 4, which would allow state and local governments to use public money to help finance political campaigns — something California largely has prohibited since 1988. The measure would lift that prohibition, subject to restrictions on how the money could be used and who could receive it. As of Wednesday, votes were leaning slightly against the proposition.

Another undecided item, Proposition 5, would change the process for recalling an elected official. It would separate the decision to recall the official from the choice of who replaces them, creating a second election or appointment process to determine the successor. The race was very tight Wednesday, with votes in favor holding a narrow edge.

Proposition 38 is leaning toward a passing vote by a solid margin. The measure would authorize the state to issue $8.4 billion in bonds to fund immunology and immunotherapy research that aims to cure and prevent cancer, heart disease and Alzheimer’s disease. Half the money would go to a single UC-affiliated nonprofit research institute, with the other half distributed through research grants.

One closely watched item, Proposition 40 — the so-called “billionaire tax” — also is leaning toward a likely rejection from voters. The proposition would create a one-time 5% tax on individuals and trusts with wealth of more than $1 billion, with the revenue going toward healthcare, food assistance and education. State officials estimated it would generate tens of billions of dollars for the state, but others, including Gov. Gavin Newsom, warned that it would lead wealthy residents to leave California and lead to future budget problems.

Two separate ballot measures, Proposition 41 and Proposition 42, were crafted to nullify the wealth tax and still remain too close to call.

Proposition 43, meanwhile, would require a two-thirds vote, rather than a simple majority, to approve certain local government taxes. It was leaning toward rejection.

Another big-ticket item, Proposition 45, was opposed by a small margin of voters but still too close to call. It would change the state’s landmark environmental review process, the California Environmental Quality Act, by shortening deadlines and permitting rules for public and private development projects. Supporters say it would cut costly delays and expedite essential housing, transportation, water, health and education projects. But opponents say it would clear the path for more artificial intelligence data centers.

Prop. 45 “has been interesting all along because it fits in with concerns about housing affordability,” Baldassare said. However, it also raised questions about “unintended consequences” for the environment.

“CEQA reform is complicated, let’s face it,” he said. “That has made the voters more split.”

Passed

The passing propositions each won with what were considerable margins Wednesday.

They included Proposition 1, which authorizes $11.25 billion in state bonds to finance affordable housing programs, with $1.25 billion set aside for housing for veterans.

Another passing item, Proposition 2, gives lawmakers the ability to put more money into California’s “rainy day fund,” doubling the reserve from 10% to 20% of the state’s general fund revenues. It also would require the state to save more in years when tax revenues are high, helping to weather economic ups and downs. It passed with a clear majority, according to The Times tracker.

Voters also approved Proposition 3, which permanently extends a high-income tax increase on California’s highest earners. The increase was approved by voters in 2012 and was scheduled to expire in 2031. The money generated by Proposition 3 would flow to education, with 89% going to K-12 schools and 11% to community colleges. It is separate from Proposition 40 — the more controversial tax on California’s wealthiest citizens, which remains undecided.

“We saw a majority of Californians in our poll saying that the wealthy should be taxed,” Baldassare said. And while voters were warned that Proposition 40 could push billionaires out of the state, Proposition 3 seemed a more palatable way to do that.

Proposition 37 passed with a clear majority of the vote. It authorizes up to $25 billion in state-issued bonds to create a loan program to help middle-income Californians buy newly constructed homes. Qualified buyers can borrow up to 17% of the price of the home while contributing 3% of the down payment from their own funds.

“There’s been strong support for the idea of spending more money on housing affordability through bonds, not taxes, and that explains the support that we saw all along for Proposition 1 and Proposition 37, despite the fact that it’s a lot of bond money,” Baldassare said.

Rejected

Californians rejected Proposition 39, which would have required voters to provide government-issued identification when voting in person or provide identifying information on mail-in ballots. It would have changed California’s signature-based voter identification system and was a resounding rejection of the broader fight playing out over onerous voter ID measures at the national level.

This was another measure where voters received a clear message, including from governor-elect Xavier Becerra, who urged Californians to vote no, Baldassare said.

“We saw in our polling before the election that most Californians don’t think that there’s a problem with the way that we go about our elections and casting ballots and counting votes … so that sort of didn’t align with thinking,” he said.

California voters also resoundingly rejected Proposition 44. The act would have required certain nonprofit community health clinics serving low-income and medically underserved populations to spend at least 90% of their annual revenue on health care services. Those that fell short would be penalized. As of Wednesday morning, a whopping 82% of votes were against the proposition, more than any other.

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Election 2026 results: Los Angeles County, Pasadena, Inglewood, Santa Monica

Data and Graphics staff

We are tracking all races across Los Angeles County, in dozens of cities, communities and school districts.

Of note in this year’s elections are a neck-and-neck Los Angeles mayoral race, a rematch for the L.A. County sheriff and nearly 100 city council seats (two of which are in L.A.). Less prominent races cover water district boards, school district trustees and the judge’s bench. Angelenos were asked to vote on propositions, measures and charter amendments — many of which involve funding programs with bonds or new taxes — at both the county and city levels.

With a few exceptions, the Associated Press does not call local city and county races. The county has 30 days to submit certified results to the secretary of state.

Countywide

Only three races are on the ballot for all of L.A. County.

Alex Villanueva is seeking to reclaim his position leading the L.A. County Sheriff’s Department. He is running against the incumbent, Robert Luna, who unseated him in 2022.

Measure A would require binding arbitration if talks between county officials and unions representing sheriff’s deputies, firefighters, lifeguards and other public safety groups reach an impasse.

A “Yes” on Measure E would do two things: enshrine previously approved Board of Supervisors ethics reforms into the county charter, and fix a problem created by a 2024 measure that invalidated a previously approved jail alternatives funding proposal.

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Cities and communities

Six of L.A. County’s 88 cities have mayoral races, including Los Angeles, Compton, El Monte, Inglewood, Lawndale and Monrovia.

Also on the ballot are city council races and measures that would issue bonds or create taxes to fund a variety of government services.

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School districts

Across L.A. County, dozens of school and community college districts have board seats and bond measures on the ballot.

Superior Court judges

Angelenos have four Superior Court judges on their ballots.

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Water districts

Multiple water district board members will be decided by voters in Los Angeles. In several districts where voters could select multiple candidates, the two with the most votes win.

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Other races

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California Prop. 38 last-minute guide: Immunology, immunotherapy research funding

The Trump administration has frozen, terminated or delayed billions in congressionally approved research grants since last year. Proposition 38 aims to backfill some of that loss by creating a stable source of money to fund immunology and immunotherapy research.

The basics

Proposition 38 would authorize the state to issue $8.4 billion in bonds to fund immunology and immunotherapy research to uncover treatments that help the immune system fight diseases such as cancer and Alzheimer’s disease more efficiently.

The impact

The measure would require at least $4.2 billion of the funds to be used for immunology research on cancer, heart disease and Alzheimer’s. It also would authorize the state to enter a partnership with an immunology and immunotherapy research institute selected by the California Department of Public Health and allocate half of the bond revenue to it. The remaining funds would be used for competitive grants that focus solely on immunology and immunotherapy research.

Californians would take on an increased cost of $500 million to $600 million annually to repay the bond for about 20 years, according to the Legislative Analyst’s Office.

The Yes on 38 campaign says the proposition pays for itself: 10% of all proceeds from the licensing of immunotherapies must be returned to the state to offset the total cost of the bond measure, including interest.

However, it’s difficult to predict whether any research projects will lead to marketable treatments.

Dig deeper

Proposition 38 is backed by organizations including the Michael J. Fox Foundation for Parkinson’s Research and the ALS Assn., as well as a majority of local chapters of Democratic organizations across the state. Supporters say the proposed funding could give those afflicted with chronic illness hope and potentially more options for treatment.

Its opponents have said the proposed criteria for awarding the grant funding would appear to create an extremely small pool of qualified recipients. Only the California Institute for Immunology and Immunotherapy, co-founded by billionaire Gary K. Michelson, would qualify under the proposed criteria, according to No on 38, the campaign against the proposition.

Robin Swanson, spokesperson for the Yes on 38 campaign, said “lots of institutions would qualify for funds under this measure.”

But she said at a virtual news conference in mid-September that it was “very likely” that the California Institute for Immunology and Immunotherapy “will qualify for half of the funds under the current criteria.”

Ultimately, Swanson said, the decision lies with the California Department of Public Health.

More reading

Your guide to Proposition 38: Immunology and immunotherapy research funding (L.A. Times)

An analysis of Prop. 38 (California Legislative Analyst’s Office)

This CA proposition will send $4 billion to a single nonprofit. Who’s behind it? (Cal Matters)

This institute could get $4 billion from a ballot measure. With just three workers, is it ready? (Cal Matters)

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Callum Turner in major James Bond hint as he lands deal with major luxury fashion brand beloved by creator Ian Fleming

CALLUM Turner’s bid to bag the role of James Bond has had a boost — he’s advertising luggage for a fashion brand with links to the films.

The 36-year-old actor is the face of Louis Vuitton’s new trunk collection.

Callum Turner sitting in a tan outfit with a bag and a dog, in a Louis Vuitton campaign.
Callum Turner’s bid to bag the role of James Bond has had a boost — he’s advertising luggage for Louis Vuitton’s new trunk collection Credit: Gregory Harris/Courtesy of Louis Vuitton
Callum Turner at the "One Night Only" premiere.
Callum’s odds of becoming Bond were 2/1 last night Credit: Getty

Bond author Ian Fleming incorporated their suitcases into 1963 book On Her Majesty’s Secret Service.

And a set of the brand’s luggage appeared in 1985 Bond film A View to a Kill.

A source said: “Louis Vuitton is exactly the kind of fashion house Callum wants to associate himself with.

“The fact that Ian Fleming also mentioned Vuitton in his books is a clear indication that Callum is aligning himself with all the right campaigns.”

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Bond casting director Nina Gold was spotted at Bray Film Studios in Berkshire yesterday as screen tests for the role were understood to be taking place.

Callum’s odds of becoming Bond were 2/1 last night.

The Brit, who is married to singer Dua Lipa, 31, co-starred in the Fantastic Beasts movies.

Scottish actor Jack Lowden, 36, is the bookies’ favourite to take over as Bond with odds of 4/7, according to Ladbrokes.

Sinners actor Jack O’Connell, 36, and The Crown’s Josh O’Connor, 36, sit at 12/1.

Daniel Craig stepped down after the release of his fifth Bond film No Time To Die in 2021.

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Who should be the next James Bond? VOTE NOW

THE mission to find the next James Bond has been narrowed down to four actors as producers ponder the final decision this week.

The replacement will fill the boots of Daniel Craig and fans are scrambling to work out who’s taking over.

Josh O'Connor at the Los Angeles Premiere Of Netflix's "Wake Up Dead Man: A Knives Out Mystery".
Josh O’Connor is said to be a contender for the role Credit: WireImage
Jack Lowden at the 78th Emmy Awards.
Jack Lowden is also believed to have made the final round of screenings Credit: Deadline via Getty Images

After five appearances as 007, Daniel Craig hung up his tuxedo for the last time following his final performance as the secret agent in the 2021 blockbuster, No Time To Die.

Since then, fans have been left wondering which actor is up to scratch to take over.

Amazon MGM Studios, who own the franchise, are said to be keen on four actors for the job.

According to The Wrap, Callum Turner, Josh O’Connor and Jack Lowden have made it to the final round of screen tests, alongside a fourth, currently unnamed actor – thought to be Heartthrob star Jack Barton.

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So, who do you think should be the next James Bond? VOTE NOW

Love to debate? Join Sun Club for just £1.99 a month for the boldest opinion on the issues shaping Britain.

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James Bond race ‘down to last FOUR actors

THE race to find Daniel Craig’s James Bond successor has been whittled down to four actors – with final screen tests set to to take place over the coming week.

The coveted role has been up for grabs following the release of 007 blockbuster No Time To Die in 2021, Craig’s fifth and final outing as the Martini-swilling secret agent.

The race to find Daniel Craig’s James Bond successor has been whittled down to four actors Credit: Alamy

Since then, an array of high-profile Hollywood stars have been linked with the franchise, notably Australian heartthrob Jacob Elordi and Brits Theo James, Idris Elba, and James Norton.

But Jeff Bezos and Amazon MGM Studios, who paid $20million for full creative control of the 64-year old franchise in 2025, are said to be keen on four alternative actors.

According to The Wrap, Callum Turner, Josh O’Connor and Jack Lowden have made it to the final round of screen tests, alongside a fourth, currently unnamed actor – thought to be Heartthrob star Jack Barton.

Apart from a handful of other minor TV roles, little else is known about the young actor, but he has reportedly impressed producers enough to earn critical screen tests alongside his three Bond rivals.

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Callum Turner is thought to be pressing hard for the coveted role and has made it down to the final four actors Credit: Getty
Slow Horses star Jack Lowden is also in the running to play secret agent James Bond Credit: Getty
It’s understood that Josh O’Connor has also made the final four as crucial screen tests continue from Friday Credit: Getty

Fans are already convinced that Lowden has landed the role after spotting a clue in the series finale of AppleTV show Slow Horses, in which he plays MI5 agent River Cartwright.

With Cartwright’s life seemingly hanging in the balance, viewers suggested the Scottish actor might be taking time off to film the next Bond movie. 

Jack Barton, best known for his starring role in Netflix show Heartthrob, is said to be the fourth hopeful Credit: Getty
Fans are already convinced that Lowden has landed the role after spotting a clue in the series finale of AppleTV show Slow Horses (pictured) Credit: Apple TV+

“Ok so we officially have our James Bond, right???” wrote one fan on Reddit. 

Posting on X, a second added: “Does the final scene mean Jack Lowden got the Bond gig?”

“The Slow Horses season 6 finale and season 7 trailer prove that Jack Lowden will be the new James Bond,” wrote another.

Elsewhere, a fourth commented: “We will know if there is a James Bond announcement in the next couple of weeks. That is the only reason I could think that they would kill him off.”

Sadly for fans, the timing doesn’t quite add up – the seventh series of Slow Horses has already wrapped and shooting for the eighth season is currently underway, with all of the cast spotted on location in London.

Jack’s Slow Horses co-star Gary Oldman, 68, appeared to confirm he’d been cast as the next James Bond during an appearance on Canada’s The Morning Show.

“It’s been rumoured that [Jack Lowden is] on the shortlist,” he said.

“We’re going to find out pretty soon, aren’t we? Because they have picked him.

“They have made their choice, but they have not announced it yet. So my fingers are crossed for Jack.”

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French government 10-year bond yield tops 5% for first time since 2002

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French yields have been rising for weeks as lawmakers wrangle over a 2027 budget that calls for billions of euros in spending cuts to reduce a debt pile that now stands at around 120% of France’s GDP – one of the highest levels in the eurozone and well above the EU limit of 60%.


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The French Treasury’s OAT bond is also used to set interest rates across a wide swath of the economy, meaning borrowing costs could begin rising for businesses and households.

The last time it was that high was during the dot-com financial crisis.

The spread between the 10-year yield and the German 10-year bond, considered the European benchmark of creditworthiness, also surged to nearly 160 basis points.

The bond selloff puts further pressure on the government ahead of a decision Friday by the ratings agency Moody’s on France’s sovereign credit rating, with most economists expecting a downgrade that would automatically raise the government’s borrowing costs.

Prime Minister Sebastien Lecornu is trying to get a 2027 budget approved in parliament despite not having a political majority for the €43 billion ($48bn) in spending cuts he seeks.

Even if approved, the budget would bring France’s deficit down to only 5% of GDP next year, well above the 3% limit for EU members.

Meanwhile, protests over the weekend calling in part for more spending on schools and other public services, degenerated into the worst street violence seen in years.

Additional sources • AFP

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