In the build-up to the match, Borthwick had urged his side to chance their arm and throw one more pass. But Italy looked quicker witted and more ambitious throughout.
A pair of clever kicks from fly-half Paolo Garbisi – the second, a well-weighted sideways nudge to release Ioane – set up the field position from which the fly-half kicked the first points of the match on 21 minutes.
An accurate long line-out throw and an Earl rumble gave England the momentum to put Tommy Freeman in for his ninth Test try, although Smith pushed the kickable conversion wide and Italy lurked dangerously as England continued to splutter.
Five minutes before the break, Menoncello – Italy’s leading metre-maker, clean-breaker and defender-beater so far in the championship – made good on the threat.
The 23-year-old carved past a startled Heyes on the fringe of a breakdown and galloped over to put Italy 10-5 in front.
England recovered. Albeit briefly.
A smart kick from Smith switched play to Tom Roebuck, and the Sale wing showed deft footwork to scamper in on the stroke of half-time.
A pair of Smith penalties after the break stretched England’s lead out to 18-10 and England seemed to be turning the tide of the contest, with Underhill and Itoje both burrowing deep for turnovers.
However, with 25 minutes to go and the match seemingly there for the taking, England’s contrived to hand the initiative back to Italy.
Underhill and Itoje watched on grimly from the sidelines as first Garbisi’s boot and then their backline’s all-court brilliance – Ioane stepping Roebuck in a sliver of space, Menoncello bullocking on and Marin gleefully scampering in – wrenched the contest out of their grasp.
England found some late urgency as they vainly chased the game. Ollie Chessum bust a hole to spin the Italian defence, but the scramble snuffed out the danger.
England looked dazed and at the end of days, as the clock went red, the ball went dead and the Stadio Olimpico lit up and leapt to its feet around them.
Defeat by France in Paris next weekend would mark only the third time in the 115-year history of the Five and Six Nations that England have lost four games in a single campaign.