An Iranian missile slammed into the main hospital in southern Israel, wounding people and causing “extensive damage,” according to the medical facility.
However, IRNA, the Islamic Republic News Agency, has said on Telegram that the “main target” of the missile attack early on Thursday “was the large [Israeli army] Command and Intelligence (IDF C4I) headquarters and the military intelligence camp in the Gav-Yam Technology Park”.
It said that this facility is located next to Soroka hospital in Be’er Sheva.
IRNA claimed that the hospital only suffered minor damage from the shockwave resulting from the missile attack.
“The military infrastructure was a precise and direct target,” it said.
Israeli Prime Minister Benjamin Netanyahu condemned the attack and promised a response, saying: “We will exact the full price from the tyrants in Tehran.”
Another missile hit a high-rise building and several other residential buildings in at least two sites near Tel Aviv. At least 47 people were wounded in the attacks, according to Israel’s Magen David Adom rescue service.
Israel, meanwhile, carried out strikes on Iran’s Arak heavy water reactor in its latest attack on the country’s sprawling nuclear programme, on the seventh day of a conflict that began with a surprise wave of Israeli air strikes targeting military sites, senior officers and nuclear scientists.
Israel’s military said its fighter jets targeted the Arak facility and its reactor core seal to stop it from being used to produce plutonium.
Israel separately claimed to have struck another site around Natanz that it described as being related to Iran’s nuclear programme.
Iranian state TV said there was “no radiation danger whatsoever” from the attack on the Arak site.
Israel is the only nuclear-armed state in the Middle East – but does not acknowledge having such weapons.
DUBAI, United Arab Emirates — Iran’s supreme leader on Wednesday rejected U.S. calls for surrender in the face of more Israeli strikes and warned that any military involvement by the Americans would cause “irreparable damage to them.”
The second public appearance by Ayatollah Ali Khamenei since the Israeli strikes began six days ago came as Israel lifted some restrictions on daily life, suggesting that the missile threat from Iran was easing.
Khamenei spoke a day after President Trump demanded in a social media post that Iran surrender without conditions and warned Khamenei that the U.S. knows where he is but has no plans to kill him, “at least not for now.”
Trump initially distanced himself from Israel’s surprise attack on Friday that triggered the conflict, but in recent days he has hinted at greater American involvement, saying he wants something “much bigger” than a ceasefire. The U.S. has also sent more military aircraft and warships to the region.
‘Nobody knows what I’m going to do’
Speaking to reporters at the White House Wednesday, Trump would not say whether he has decided to order a U.S. strike on Iran, a move that Tehran warned anew would be greeted with stiff retaliation if it happens.
“I may do it, I may not do it,” Trump said in an exchange with reporters at the White House. “I mean, nobody knows what I’m going to do.”
Trump added that it’s not “too late” for Iran to give up its nuclear program as he continues to weigh direct U.S. involvement in Israel’s military operations aimed at crushing Tehran’s nuclear program.
“Nothing’s too late,” Trump said. “I can tell you this. Iran’s got a lot of trouble.”
“Nothing is finished until it is finished,” Trump added. But “the next week is going to be very big — maybe less than a week.”
Trump also offered a terse response to Khamenei’s refusal to heed to his call for Iran to submit to an unconditional surrender.
“I say good luck,” Trump said.
‘The Iranian nation is not one to surrender’
Khamenei dismissed the “threatening and absurd statements” by Trump.
“Wise individuals who know Iran, its people and its history never speak to this nation with the language of threats, because the Iranian nation is not one to surrender,” he said in a low-resolution video, his voice echoing. “Americans should know that any military involvement by the U.S. will undoubtedly result in irreparable damage to them.”
Iran released Khamenei’s statement before the video was aired, perhaps as a security measure. His location is not known, and it was impossible to discern from the tight shot, which showed only beige curtains, an Iranian flag and a portrait of Grand Ayatollah Ruhollah Khomeini, Khamenei’s immediate predecessor, who died in 1989.
An Iranian diplomat had warned earlier Wednesday that U.S. intervention would risk “all-out war.”
Foreign Ministry spokesperson Esmail Baghaei did not elaborate, but thousands of American troops are based in nearby countries within range of Iran’s weapons. The U.S. has threatened a massive response to any attack.
Another Iranian official said the country would keep enriching uranium for peaceful purposes, apparently ruling out Trump’s demands that Iran give up its disputed nuclear program.
Strikes in and around Tehran
The latest Israeli strikes hit one facility used to make uranium centrifuges and another that made missile components, the Israeli military said. Military officials said their defenses intercepted 10 missiles overnight as Iran’s retaliatory barrages diminished. The U.N. nuclear watchdog agency said Israel struck two centrifuge production facilities in and near Tehran.
Israeli Defense Minister Israel Katz said the military also struck the headquarters of Iran’s internal security forces on Wednesday, without specifying the agency or location. The strike marks a shift toward targeting Iran’s domestic security apparatus, which has long cracked down on dissent and suppressed protests.
Israel’s air campaign has struck several nuclear and military sites, killing top generals and nuclear scientists. A Washington-based Iranian human rights group said at least 585 people, including 239 civilians, have been killed and more than 1,300 wounded.
Iran has fired some 400 missiles and hundreds of drones in retaliatory strikes, killing at least 24 people in Israel and wounding hundreds. Some have hit apartment buildings in central Israel, causing heavy damage, and air-raid sirens have repeatedly forced Israelis to run for shelter.
Iran has fired fewer missiles as the conflict has worn on. It has not explained the decline, but Israel has targeted launchers and other infrastructure related to the missiles.
By Wednesday, Israel eased some of the restrictions that it had imposed on daily life when Iran launched its retaliatory attack, allowing gatherings of up to 30 people and letting workplaces reopen as long as there is a shelter nearby.
Schools are closed, and many businesses remain shuttered, but Israel’s decision to reverse its ban on gatherings and office work for all but essential employees signals the Israeli military’s confidence that its attacks have limited Iran’s missile capabilities.
Casualties mount in Iran
The Washington-based group Human Rights Activists said it had identified 239 of those killed in Israeli strikes as civilians and 126 as security personnel.
The group, which also provided detailed casualty figures during 2022 protests over the death of Mahsa Amini, crosschecks local reports against a network of sources it has developed in Iran.
Iran has not been publishing regular death tolls during the conflict and has minimized casualties in the past. Its last update, issued Monday, put the toll at 224 people killed and 1,277 others wounded.
Shops have been closed across Tehran, including in its famed Grand Bazaar, as people wait in gas lines and pack roads leading out of the city to escape the onslaught.
A major explosion was heard around 5 a.m. Wednesday in Tehran. That followed other explosions earlier in the predawn darkness. Authorities in Iran offered no acknowledgement of the attacks, which have become increasingly common as the Israeli airstrikes have intensified.
At least one strike appeared to target Tehran’s eastern neighborhood of Hakimiyeh, where the paramilitary Revolutionary Guard has an academy.
Iran says it will keep enriching uranium
Israel says it launched the strikes to prevent Iran from building a nuclear weapon, after talks between the United States and Iran over a diplomatic resolution made little visible progress over two months but were still ongoing. Trump has said Israel’s campaign came after a 60-day window he set for the talks.
Iran has long insisted its nuclear program is peaceful, though it is the only non-nuclear-armed state to enrich uranium up to 60%, a short, technical step away from weapons-grade levels of 90%. U.S. intelligence agencies have said they did not believe Iran was actively pursuing the bomb.
Israel is the only country in the Middle East with nuclear weapons, but has never publicly acknowledged them.
Iran’s ambassador to Geneva, Ali Bahreini, told reporters that Iran “will continue to produce the enriched uranium as far as we need for peaceful purposes.”
He rejected any talk of a setback to Iran’s nuclear research and development from the Israeli strikes, saying, “Our scientists will continue their work.”
Israel welcomes first repatriation flights
Israelis began returning on flights for the first time since the country’s international airport shut down at the start of the conflict.
Two flights from Larnaca, Cyprus, landed Wednesday at Tel Aviv’s Ben Gurion International Airport, said Lisa Dvir, an airport spokesperson.
Israel closed its airspace to commercial flights because of the ballistic missile attacks, leaving tens of thousands of Israelis stranded abroad.
Krauss, Gambrell and Frankel write for the Associated Press. Frankel reported from Jerusalem. Associated Press writers Amir Vahdat and Nasser Karimi in Iran, and Jamey Keaten in Geneva, contributed.
Tel Aviv, Israel – For the fourth night in a row, missiles have hit Israeli cities. Iran’s retaliatory strikes, triggered by Israeli attacks, saw people sheltering in stairwells and bomb shelters as the scale of the damage and Iranian rockets managing to penetrate one of the world’s most sophisticated defence systems have left many reeling.
On Friday, Israel began its assault on Iran, targeting military and nuclear facilities and killing high-profile security, intelligence and military commanders as well as scientists. Israel’s attacks, which have also targeted residential areas, have killed more than 224 people and wounded at least 1,481, according to Iranian authorities. The government said most of those killed and wounded have been civilians.
In response, Iran has fired barrages of missiles towards Tel Aviv and other Israeli cities.
Hundreds of Iranian missiles have been launched since Friday, and Israel’s air defence systems, though robust, have been unable to stop all of them. While the number of missiles fired by Iran appears to have gone down on a night-by-night basis, the scale of the attacks continues to be unprecedented for Israelis.
Central Tel Aviv, Haifa, the scientific hub of Rehovot and homes have been struck. At least 24 people in Israel have been killed in the strikes and hundreds wounded.
The Weizmann Institute of Science in Rehovot, a source of national pride and a cornerstone of Israeli military research, was among the hardest hit. Its laboratories were torn open, glass panes shattered, and cables and rebar left dangling.
“This isn’t just damage to buildings,” said Jenia Kerimov, 34, a biology PhD candidate who lives nearby. “It’s years of research, equipment we can’t easily replace, data that might be lost forever.”
She had been in a bomb shelter a block away when the institute was struck. “We’re supposed to be helping protect the country. But now even our work, our home, feels exposed.”
Shelters across the country are packed. In older neighbourhoods without bunkers, residents crowd into communal safe rooms. In Tel Aviv and West Jerusalem, stairwells have become makeshift bedrooms. The Israeli military’s Home Front Command has evacuated hundreds of people to hotels after buildings that were hit were deemed uninhabitable.
‘No shelter in our building’
Yacov Shemesh, a retired social worker in West Jerusalem, said his wife has been sleeping on the stairs in their apartment block since the attacks began.
“There’s no shelter in our building,” the 74-year-old explained. “I went to the roof Sunday night to see what was happening. I saw a flash in the sky and then a boom. But I couldn’t find anything in the news. Maybe they [the state] don’t want us to know how close it came.”
The barrage has triggered panic in a society long shaped by conflict – but where, until now, the destruction and wars were inflicted elsewhere – in Gaza, Jenin or southern Lebanon. Now, many Israelis are being confronted with destruction in their home cities for the first time.
In Tel Aviv, long lines snaked through the aisles of a grocery store. Despite being crowded, the atmosphere was hushed as customers tapped their phones, their faces drawn tight.
Gil Simchon, 38, a farmer from near the Ramat David Airbase, east of Haifa, stacked bottles of water in his arms.
“It’s one thing to hear for decades about the Iranian threat,” he said, “but another to see it with your own eyes – to see high rises in Tel Aviv hit.”
On Monday night, he used a bomb shelter for the first time in his life.
Even the Kirya, Israel’s military headquarters in Tel Aviv, was struck although damage was limited. Iran’s ability to hit such a fortified and symbolically vital target has deeply rattled a population raised on the reliability of its multilayered defence architecture.
While much of Israel is covered by the Iron Dome, David’s Sling and Arrow defence systems, officials admit these were not designed for a saturation attack involving ballistic missiles with heavy warheads. “These aren’t homemade rockets from Gaza,” one analyst said on Israeli television. “These are battlefield weapons.”
On Saturday night, the streets of West Jerusalem were quiet. One of the few lit spaces was a gym. Its owner gestured to the staircase descending underground. “We’re protected,” he said. Then with a smile, he added, “Gymgoers are crazy. If you’re working out at night, the gym had better be open.”
Outside, the night air buzzed with tension. A neon sign flared against the darkness. A small group gathered, eyes fixed on the sky. Moments earlier, streaks of light had passed overhead.
“They’re headed somewhere else – Haifa, I think,” a young man muttered. Minutes later, sirens wailed. Video soon appeared online showing flames erupting from a gas installation near Haifa.
Initially, social media was flooded with footage of missile impacts – some from residential balconies, others from dashcams. By the third night, multiple reports were published of people being arrested for documenting the attacks while Israeli officials warned foreign media against breaking a ban on broadcasting such content, describing it as a security offence.
Meanwhile, fears of power outages are growing. In Tel Aviv, drivers queued at petrol stations, anxious to keep their tanks full. A father strapped his children into the back seat before speeding away. His eyes flicked to the clouds, then the rear-view mirror.
Israeli police inspect a damaged apartment near the site where an Iranian missile destroyed a three-storey building in the city of Tamra, killing four women, according to rescue workers and medics [Ahmad Gharabli/AFP]
‘Protecting ourselves and making it worse’
For some Israelis abroad, a feeling of helplessness has deepened. Eran, 37, who lives and works in New York, spoke to his elderly parents near the city of Beit Shemesh. “They’ve gone to shelters before, but this time, the fear was different,” he tells Al Jazeera. “The shelter was full. When they returned home, they found pieces of interceptor debris in the yard.”
Eran, a former conscientious objector who refused Israel’s mandatory military draft – for which he spent time in jail – and asked to use a pseudonym for fear of state reprisal upon his return to Israel, has long been critical of Israeli policies. Now watching his family in danger, he feels more certain than ever.
“Israel claims to act for all Jews,” he said. “But its crimes in Gaza and elsewhere just bring danger to families like mine. Even in New York, it impacts me.”
For others, the picture is murkier.
“I don’t know any more where the line is between protecting ourselves and making it worse,” Gil said. “You grow up believing we’re defending something. But now, the missiles, the shelters, the fear – it feels like a cycle we can’t see out of.”
The Israeli government, meanwhile, has struck a belligerent tone, promising to make Tehran “pay a heavy price”. But in the shelters, tension is mixed with exhaustion and a growing recognition that something fundamental has changed.
“It’s like the feeling of a meat lover after they visit a meat-packing factory,” Gil said quietly. “You grow up on it, you believe in it – but when you see how it’s made, it makes you uneasy.”
This piece was published in collaboration with Egab.
Many Israelis are in shock after the country’s air defence system failed to intercept Iranian missiles, shattering their sense of security. But Palestinian citizens of Israel say they never felt safe to begin with.