Health

Republican Sen. Susan Collins discloses her longtime tremor after scrutiny in Maine’s Senate race

Republican U.S. Sen. Susan Collins says she has a benign essential tremor, disclosing the longtime health condition for the first time in her decades-long political career as she seeks reelection in one of this year’s toughest Senate races.

Collins first confirmed the tremor to WCSH-TV in Maine on Wednesday after facing questions about her health from appearances in recent videos, including her campaign announcement video.

The condition causes trembling in Collins’ hands, head and voice, and she said she has had it for the entirety of her nearly three-decade Senate career. It affects millions of Americans over the age of 40 and “does not interfere” with work, Collins said in a Thursday statement to the Associated Press. She said it is not a neurodegenerative condition.

“The tremor is occasionally inconvenient, and sometimes the subject of cruel comments online, but it does not hinder my ability to work and, as I said, is something that I have lived with for decades,” the statement said.

Health issues and candidates’ ages have drawn increased scrutiny in high-profile elections following Democratic President Joe Biden’s decision not to seek reelection in 2024 at age 81. Those questions have only lingered with Republican President Trump, who’s 79 and in recent months has been seen with bruising on the back of his hand, sometimes concealed with makeup. The White House acknowledged last year that Trump was diagnosed with chronic venous insufficiency.

Collins is up for reelection in a seat Democrats need to flip to have a chance to take back the Senate. Her likely opponent is Democrat Graham Platner, an oyster farmer and combat veteran, after Democratic Gov. Janet Mills suspended her campaign last week. Age has been an issue in the contest, with Collins, 73, and Mills, 78, more than three decades older than Platner, 41.

Platner acknowledged early in his campaign his own health problems. He has spoken openly about chronic pain in his shoulder and knees stemming from combat service, and he has said he was diagnosed with post-traumatic stress disorder after serving at war. Platner has said he has a 100% disability rating from the U.S. Department of Veterans Affairs but continues to work as an oyster farmer.

“There are a lot of disabled combat veterans, or just disabled vets, at 100%, who still work,” Platner told WCSH last year. “It’s a very normal thing.”

Collins was first elected to the Senate in 1996 and said in her statement that she has had the condition for all of that time. Over the years, the condition has been noticeable in Collins’ debates and frequent public appearances.

As chair of the Senate Appropriations Committee, Collins has been at the forefront of the chamber’s many spending disputes this Congress, often leading the floor debate and providing the GOP’s closing arguments. She frequently engages with reporters in the hallways. Her streak of never missing a Senate vote is up to 9,966 and stands as the second-longest consecutive voting streak in the chamber’s history.

Tremors happen when nerves aren’t properly communicating with certain muscles. Essential tremor, sometimes called benign essential tremor, is one of the most common movement disorders, according to the National Institutes of Health.

The risk of developing it increases as people get older, but at least half of cases are inherited, meaning the tremor runs in the family, and those tend to begin at younger ages. It almost always involves shaky or trembling hands but also can affect the head, voice or lower limbs.

Whittle and Kruesi write for the Associated Press. Kruesi reported from Providence, R.I. AP writers Kevin Freking and Lauran Neergaard in Washington contributed to this report.

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BBC Radio 2 legend Bob Harris shares new health update with fans after revealing his cancer has spread

BBC RADIO 2 legend Bob Harris has shared a new health update with fans, after revealing that his cancer has spread. 

The radio star, who previously revealed he was forced to take a break from broadcasting as a result of his health issues, posted a new image of himself with a big grin and a thumbs up. 

Bob Harris shared a new health update with fans, after revealing that his cancer has spread Credit: Instagram/whisperingbob
BBC Radio 2 legend Bob has experience recent setbacks in his cancer battle Credit: Instagram/whisperingbob

Bob, 80, could be seen sitting at home in a gown and appeared in good spirits, while writing to fans: “Hiya Folks! I hope you’re all ok. Sending you all my love.” 

The star, who is resting up at home and out of hospital, was flooded with sweet messages from fans. 

One person wrote: “Sending all the love your way,” while another added: “Fab photo Looking great. Keep up the good work.” 

Bob, 80, was initially diagnosed with prostate cancer in 2007 and managed the disease with treatment before recent setbacks.

‘FRIGHTENING NEWS’

BBC Radio 2’s Bob Harris reveals his cancer has spread in health update


‘ROAD TO RECOVERY’

BBC Radio 2’s Bob Harris taking a break after surviving a heart scare

Last month, he shared how his cancer has spread from his prostate to his upper spine Credit: Instagram/whisperingbob
Bob shared a photo of himself walking with a stick Credit: Instagram

Last month, he shared how his cancer has spread from his prostate to his upper spine.

Taking to Instagram to update his fans at the time, Bob shared a photo of himself walking with a stick.

“I’m sorry it’s been so long since I last posted but the past few weeks have proved to be an extremely testing time,” he penned in the caption.

Bob went on: “When I posted last time from hospital, we were trying to find the reason for the excruciating pain I was feeling in my back.

“Several scans later, we discovered that my prostate cancer has got into my upper spine…really frightening news.

“So, I immediately began a course of radiotherapy – two weeks in hospital in total – to bring things back under control. Thankfully I’m back at home now, on the pathway to recovery and feeling stronger every day.”

He added: “I have started a programme of rehab and today I got out into this glorious weather for the first time with my son @expiredfilmclub who took the photograph.

“Just want to send so much love to Zoe and to everyone who have been in touch.

What are the symptoms of prostate cancer?

Symptoms of prostate cancer can include:

  • needing to pee more frequently, often during the night
  • needing to rush to the toilet
  • difficulty in starting to pee (hesitancy)
  • straining or taking a long time while peeing
  • weak flow
  • feeling that your bladder has not emptied fully
  • blood in urine or blood in semen

Source: NHS

Bob has faced a lengthy health battle Credit: Instagram/whisperingbob

“See you soon folks! xxx.”

Bob previously suffered a heart scare that forced him off the air in 2019

He suffered a tear to his aorta which he described as “extremely serious” at the time.

Bob has hosted The Country Show on BBC Radio 2 for a number of years and famously hosted BBC Two music show, The Old Grey Whistle Test, in the 1970s.

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Spain agrees to let hantavirus-hit cruise ship dock in Canary Islands | Health News

Spain has granted permission for a luxury cruise ship hit by a deadly hantavirus outbreak and anchored off the coast of Cape Verde to sail to the Canary Islands.

Spain’s Ministry of Health said in a statement late on Tuesday that the World Health Organization (WHO) had explained that Cape Verde in West Africa was unable to receive the 147 crew and passengers of the MV Hondius.

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“The Canary Islands are the closest location with the necessary capabilities,” it said. “Spain has a moral and legal obligation to assist these people, among whom are also several Spanish citizens.”

The ministry said it would receive a medical flight carrying the ship’s doctor, a Dutch national, who it said was gravely ill, following a formal request from the Dutch government.

A Dutch couple and a German national have died of the rare disease, which is usually spread from infected rodents through urine, droppings and saliva, on board the ship in early April. A British national, who was evacuated from the ship, is in intensive care in South Africa, officials said.

Two crew members require urgent medical care, ⁠according to the Dutch-flagged ship’s operator, Oceanwide Expeditions. Another person on board with a suspected case has only reported a mild fever.

Medical evacuations

The Spanish Health Ministry said the MV Hondius will journey on to the Canary Islands once those who need evacuation are taken off the ship.

The Dutch government said earlier on Tuesday that it was preparing to receive the evacuated passengers. Oceanwide Expeditions said the journey to the Canary Islands will take three days of sailing and that the MV Hondius will dock in either Gran Canaria or Tenerife.

When the rest of the crew and passengers arrive in the Canary Islands, they will be examined, treated and repatriated to their respective countries, Spain’s Health Ministry said, in coordination with the European Centre for Disease Prevention and Control and the WHO.

All necessary safety measures would be taken, the ministry said, with medical care and transportation provided in special facilities and vehicles to avoid contact with the local population and protect health workers.

According to the WHO, the cruise ship, which set sail from Ushuaia, Argentina, on April 1 for Cape Verde, had 88 passengers and 59 crew members from 23 countries on board.

A WHO official said on Tuesday that she suspected some rare human-to-human transmission had occurred between close contacts on board the ship.

“We do believe that there may ⁠be some human-to-human transmission that’s happening among the really close contacts, the husband and wife, people who have shared cabins,” Maria Van Kerkhove, the director of epidemic and pandemic preparedness and prevention at the WHO, told reporters in Geneva.

Van Kerkhove also sent a direct message to the people on board.

“We just want you to know we are working with the ship’s operators,” she said. “We are working with the countries where you are from. We hear you. We know that you are scared.”

Andes strain

Human-to-human transmission is not common, and the WHO reiterated that ⁠the risk to the wider public was low, adding that it had been told that “there are no rats on board” the ship.

A limited spread among close contacts has been observed in some previous outbreaks of the Andes strain of the virus, which spreads in South America, including Argentina.

Van Kerkhove said the typical incubation period for hantavirus was between one and six weeks, leading the WHO to believe that the Dutch couple, who had been travelling in Argentina before boarding the cruise, “were infected off the ship”.

Other cases may also have been infected while on bird-watching trips to islands where birds and rodents live, the WHO said.

Such trips are part of the cruise.

The Hondius is carrying mostly British, American and Spanish passengers on the luxury cruise, which set off from the southern tip of Argentina in late March.

The cruise visited the Antarctic Peninsula, South Georgia and Tristan da Cunha, some of the remotest islands ‌on the planet.

The voyage was marketed as an Antarctic nature expedition, with berth prices ranging from 14,000 to 22,000 euros ($16,000 to $25,000).

The first stricken passenger, the Dutch man, died on April 11. His body remained on board until April 24, when it “was disembarked on St Helena, with his wife accompanying the repatriation”, Oceanwide Expeditions said.

His wife had gastrointestinal symptoms when she was disembarked, and deteriorated during a flight to Johannesburg. She died upon arrival at the emergency department on ‌April ‌26, the WHO said, adding that contact tracing was under way for passengers on the flight.

South African authorities have confirmed that the British patient, who is being treated in a Johannesburg hospital, tested positive for the hantavirus.

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Zambia blasts the U.S. over a $2-billion health deal in exchange for critical minerals

Zambia is accusing the United States of tying a $2-billion deal for critical health assistance to access to the southern African nation’s rich mineral assets, and calling the outgoing U.S. ambassador’s allegations of corruption “mischievous” and “undiplomatic.”

The comments by Zambia’s foreign affairs minister, Mulambo Haimbe, on Monday brought into the open simmering tensions over President Trump’s “America First” strategy, which is reshaping aid to Africa into transactional agreements.

Some African leaders and health experts have criticized the new U.S. stance and its demands for sensitive health data in exchange for badly needed support for health systems strained by the Trump administration’s dismantling of foreign aid. Some say they would not receive access to health innovations like vaccines in return.

The U.S. is also seeking to challenge China, a dominant player in Zambia and much of Africa, whose minerals are critical to the green energy transition, including inputs for solar panels, electric vehicle batteries and energy storage systems.

Zambia says talks stalled over data-sharing demands

In a statement, Haimbe described the accusations of Zambian graft and negotiation inertia by outgoing U.S. ambassador Michael Gonzales as “mischievous” and “deeply regrettable, undiplomatic and inconsistent with the spirit of mutual respect.”

Haimbe also accused the U.S. of tying access to critical minerals to the conclusion of the health deal, which Gonzales earlier dismissed as “alarmist allegations” that he called “disgusting” and “absolutely and patently false.”

Negotiations have continued for months to conclude the deal, one of dozens the Trump administration is pursuing in some of the world’s most aid-dependent countries.

Gonzales in late April said Zambian leaders had “abdicated their responsibilities, letting the United States pay for healthcare while officials diverted government funds to their own pockets.” He said Zambian authorities had “ignored” U.S. overtures to conclude a new deal.

But Haimbe said negotiations had stalled over “unacceptable” data-sharing demands “in violation of our citizens’ right to privacy” and “the insistence on preferential treatment of U.S companies over Zambia’s critical minerals.”

Zambia “takes the view, first and foremost, that Zambians must have a say on how her critical minerals are used, and second that no one strategic partner is to be treated preferentially to others,” he said.

The U.S. Embassy did not immediately respond to a request for comment.

U.S. says its approach aims to reduce donor dependency

The U.S. approach replaces decades of engagement anchored in the now-dismantled United States Agency for International Development and the President’s Emergency Plan for AIDS Relief, or PEPFAR.

In their place, U.S. officials are negotiating country-by-country agreements that recast aid as a transaction, tying funding to conditions including commercial provisions, domestic financing commitments, disease surveillance, pathogen sharing and even religion.

Since late last year, the U.S. has signed agreements with about 30 countries, many in Africa. Washington says the approach is meant to reduce donor dependency, promote local ownership and safeguard American interests, including against an aggressive China that dominates trade in Africa but contributes less aid.

There has been pushback.

Ghana last week said it had rejected a proposed deal over provisions granting broad access to sensitive health data without safeguards. Zimbabwe walked away from a $367-million package over similar concerns. In Kenya, a $2.5- billion agreement signed in December has been put on hold after a court challenge arguing it violates data protection laws.

In Lesotho, draft U.S. proposals sought 25 years of access to health data and biological samples before local officials secured a shorter five-year deal.

Health experts say data would largely flow one way

Critics say the data-sharing demands tilt toward U.S. interests and warn the information-sharing would largely go in just one direction: toward Washington.

The new agreements aim to ensure the flow of disease surveillance data and biological samples, but through bilateral channels, after the U.S withdrew from the World Health Organization in January, said Asia Russell, executive director of advocacy group Health GAP.

Countries currently report disease outbreaks primarily through the WHO, which coordinates responses and is negotiating new frameworks on pathogen-sharing and equitable access to vaccines.

The U.S., now outside those talks, is pursuing direct access instead.

“[The U.S. wants] to understand what’s actually happening,” said Jen Kates, a senior vice president at the Washington-based nonprofit KFF. “But they are trying to do it in a very different way.”

Health advocates say this risks creating a parallel global health system. In Zimbabwe, a government spokesperson in February said the government terminated negotiations because the U.S. was not offering a “corresponding guarantee of access to any medical innovations — such as vaccines, diagnostics or treatments — that might result from that shared data.”

“That raises serious concerns about who benefits,” said Atilla Kisla of the Southern Africa Litigation Center.

Advocates point to the harsh experience of the COVID-19 pandemic, when African countries contributed data and samples but were largely last in line for vaccines.

Experts warn against health as a ‘bargaining chip’

The agreements with the U.S. are drawing criticism for closed-door negotiations and limited public scrutiny.

“Secrecy is at the center of this. That puts accountability for results at risk,” said Health GAP’s Russell. “It’s impossible to evaluate these deals properly without seeing the full terms. Part of what made PEPFAR successful was transparency. Now that’s been taken away.”

The deals also come with tighter financial conditions. Many include reduced funding compared to previous levels of U.S. assistance, while requiring countries to increase domestic health spending, with aid at risk if targets are not met.

“These are going to be very heavy lifts,” said KFF’s Kates. “Countries are already under strain.”

Critics say some agreements also advance U.S. commercial and political interests, blurring the line between aid and transactional diplomacy.

“When health becomes a bargaining chip, everyone becomes less safe,” Russell warned.

Mutsaka and Imray write for the Associated Press. Keketso Phakela in Maseru, Lesotho, contributed to this report.

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Miriam Margolyes says ‘I need help’ as she shares update on 40-year health issue

Miriam Margolyes opened up about the health problems she lives with and issued a warning to others on how one of them could be prevented

Miriam Margolyes has shared an update on a health problem she has lived with for more than 40 years. The 84-year-old revealed she suffers from a long-term shoulder injury that means she is unable to put on a bra by herself.

Reflecting on being filmed in her bra for her latest documentary Miriam Margolyes Made Me Me, she said on The Romesh Ranganathan Show: “I did have that new bra on and it did me the world of good.

I need several people to put it on for me and I’m on my own at the moment.

“The problem is, I’ve got a bad shoulder, I’ve had it for a long time actually because I didn’t know how to fall and I had to fall in a play for six months about 40 years and the rotator cuff doesn’t quite cuff or rotate, whatever it should do.

“So, I can’t put my hands behind my back. I can manage with an apron because it’s lower down, but with a bra it’s a little bit [more difficult] and you have to sort of arrange your t**s into it.

“And I need help basically, so my lodgers do bra duty, but I haven’t got them with me today so I had to do it myself,” the actress shared.

In the same podcast, the Harry Potter star opened up about what she considers the “worst bit” of being in her eighties.

Asked for advice by Romesh’s mother, she said: “The worst bit about being 80 is my weak pelvic floor. I p**s myself all the time and everywhere I go I always take spare knickers because you never know.

“And that’s honestly the truth and I don’t like it and I don’t say it to be funny, I say it because it’s true and it’s a bl***y nuisance,” Miriam added.

“But if I done pelvic floor exercises maybe I wouldn’t be so p***y. So do your pelvic floor exercises,” she warned.

On a more positive note, the actress said the “best thing” about turning 80 is the confidence she now feels when meeting new people.

“The best thing about being 80 and I’m going to be 85 [soon], is not being afraid to meet people, not being afraid to go into a room and just be.

“Sometimes, that’s because people know who I am and they’re sort of starstruck because they think I’m a star, but it gives me confidence.

“I feel more empowered to be and go into a room and talk to people,” she added.

Miriam has faced a number of other health challenges over the years, including undergoing an aortic valve replacement in 2023. She also lives with Spinal stenosis, which has affected her mobility.

She previously told Closer Magazine: “I can’t walk very well, and I’m registered disabled. I use all kinds of assistance. I’ve got two sticks and a walker and they’re such a bore, but I’ve just got a mobility scooter, which is a lot of fun.”

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US Supreme Court temporarily lifts ban on abortion pill mail delivery | Health News

The United States Supreme Court has temporarily reinstated a rule allowing an abortion pill to be prescribed through telemedicine and dispensed through the mail, lifting a judicial ban that narrowed access to the medication nationwide.

Justice Samuel Alito issued an interim order on Monday, pausing for one week a decision by the New Orleans-based 5th US Circuit Court of Appeals to reimpose an older federal rule requiring an in-person clinician visit to receive mifepristone.

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The 5th Circuit acted in a challenge to the rule by the Republican-led state of Louisiana.

The Supreme Court’s action, called an “administrative stay”, gives the justices more time to review emergency requests by two manufacturers of mifepristone to ensure that the drug can be provided via telehealth and the mail while the legal challenge plays out.

Alito ordered Louisiana to respond to the drugmakers’ requests by Thursday and indicated that the administrative stay would expire on May 11. The court would be expected to extend the interim stay or formally decide the requests by that time.

Alito, one of the nine-member court’s six conservative justices, acted because he is designated by the court to oversee emergency matters that arise in a group of states that includes Louisiana.

The case puts the contentious issue of abortion back in front of the justices, who must confront another effort by abortion opponents to scale back access to mifepristone, with the November US congressional elections looming.

The court in 2024 unanimously rejected an initial bid by anti-abortion groups and doctors to roll back Food and Drug Administration (FDA) regulations that had eased access to the drug, ruling that these plaintiffs lacked the necessary legal standing to pursue the challenge.

Mifepristone, given FDA regulatory approval in 2000, is taken with another drug called misoprostol to perform medication abortions, a method that now accounts for more than 60 percent of all abortions in the US.

The ongoing battles over abortion rights follow the court’s 2022 ruling that overturned its 1973 Roe v Wade precedent that had legalised abortion nationwide.

That ruling has prompted 13 states to enact near-total bans on the procedure, while several others have sharply restricted access.

Louisiana sued the FDA last year, claiming that a rule adopted during the administration of former US President Joe Biden, a Democrat – a rule that eased access to mifepristone by eliminating the in-person dispensing requirement – is illegal and undermines the state’s abortion ban.

The pill’s manufacturer, Danco Laboratories, and GenBioPro, which makes a generic version, intervened in the litigation to defend the 2023 regulation. The administration of current US President Donald Trump, a Republican, cited an ongoing review of safety regulations concerning mifepristone and opposed the state’s challenge.

In April, US Judge David Joseph in Lafayette, Louisiana, declined to block the regulation but agreed with the administration to put the case on hold pending the review. The 5th Circuit blocked the rule on May 1.

The legal and political fight over access to mifepristone has dominated the debate over abortion in the US over the past few years.

The American Civil Liberties Union (ACLU) called the top court’s decision on Monday a “positive short-term development”.

“The Supreme Court needs to put an end to this baseless attack on our reproductive freedom, once and for all,” Julia Kaye, senior lawyer for the Reproductive Freedom Project of the ACLU, said in a statement.

Since the Supreme Court revoked the right to abortion in 2022, Democrats have been seizing on the unpopularity of bans on the procedure and emphasising the issue in their electoral platforms.

Chuck Schumer, the top Democrat in the Senate, welcomed the top court’s decision on Monday, but said, “This fight is just beginning.”

“We will stop at nothing to prevent the Republicans from putting a national abortion ban into effect,” Schumer wrote on X.

On Monday, Republican Senator Josh Hawley cited disputed findings on the health risks associated with mifepristone, urging lawmakers to act.

“Now it’s time for Congress to ban it completely for use in abortion,” he said in a social media post.

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Three dead in suspected hantavirus outbreak on Atlantic cruise ship | Health News

Three of six passengers who fell ill from suspected rodent-transmitted virus have died, and one is in intensive care, the WHO says.

Three people have died on a cruise ship in the Atlantic, with at least one confirmed to have suffered from hantavirus, a rare disease transmitted to humans from rodents.

Health authorities are now investigating a suspected outbreak of the virus on the MV Hondius, which is sailing from Ushuaia in Argentina to Cape Verde.

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In a statement on Sunday, the World Health Organization said that one case had been confirmed and at least five other passengers were suspected of being infected.

“Of the six affected individuals, three have died, and one is currently in intensive care in South Africa,” WHO said in a statement.

“Detailed investigations are ongoing, including further laboratory testing and epidemiological investigations. Medical care and support are being provided to passengers and crew. Sequencing of the virus is also ongoing.”

WHO added that it was “facilitating coordination” between countries to evacuate the two other passengers showing symptoms of the infection.

Hantavirus, a rare disease transmitted to humans through the droppings or urine of infected rodents, can be fatal in severe cases and cause hemorrhagic fever.

Infected couple among casualties

South Africa’s National Department of Health said earlier on Sunday that there had been an outbreak of a “severe acute respiratory illness”, which had killed at least two people, and that a third person was in intensive care in Johannesburg, according to the AFP news agency.

The ministry’s spokesperson, Foster Mohale, confirmed that the patient being treated in Johannesburg tested positive for hantavirus.

A 70-year-old was the first to develop symptoms. He died on the ship, with his body now being held on the island of Saint Helena, a British territory in the South Atlantic, the spokesman said.

The patient’s 69-year-old wife also fell sick and was evacuated to South Africa, where she died in a Johannesburg hospital, he added.

Mohale told AFP that authorities have not confirmed the nationalities of the deceased. But the person in intensive care was reported by AFP to be a 69-year-old Briton.

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Iranian Nobel laureate Narges Mohammadi hospitalised as health deteriorates | Human Rights News

Mohammadi has lost consciousness twice and suffered a severe cardiac crisis, her foundation has announced.

Iranian human rights activist and 2023 Nobel Peace Prize laureate Narges Mohammadi has been transferred from prison to a hospital due to a sharp decline in her health.

Mohammadi had two episodes of complete loss of consciousness and a severe cardiac crisis, her foundation announced on Friday.

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“This transfer was done as an unavoidable necessity after prison doctors determined her condition could not be managed on-site, despite standing medical recommendations that she be treated by her specialized team in Tehran,” the Narges Mohammadi Foundation said.

Earlier on Friday, Mohammadi had fainted twice in prison in Zanjan in northwestern Iran, according to the foundation.

She was believed to have suffered a heart attack in late March, according to her lawyers, who visited her a few days after the incident. At the time, she appeared pale, underweight and needed a nurse to help her walk.

‘Life-threatening mistreatment’

Mohammadi, 53, has been imprisoned since December 12 after she was arrested during a visit to the eastern Iranian city of Mashhad.

In February, she was sentenced to more than seven years in prison. Her lawyer said six years of that sentence was for the accusation of “gathering and collusion to commit crimes”.

Her family said in February that her health was worsening in prison, in part because of an alleged beating she had endured during her arrest in December. They said multiple men hit and kicked her in her side, head and neck.

The Nobel committee condemned the “ongoing life-threatening mistreatment” of Mohammadi in a statement in February.

The Iranian government has not commented on the alleged attack.

Prior to her arrest in December, Mohammadi had already been serving a sentence of 13 years and nine months on charges of collusion against state security and propaganda against Iran’s government, but had been released on furlough since late 2024 due to medical concerns.

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EasyJet says passengers should always keep one item in their hand luggage

The airline advises passengers to avoid putting it in their hold luggage if possible

EasyJet says passengers should keep one type of item with them, ideally in their hand luggage rather than their check-in bags. All passengers can bring one small under-seat cabin bag per person on board for free. It can be a maximum size of 45 x 36 x 20 cm (including any handles and wheels) and must be kept under the seat in front of you.

Regarding what travellers should keep in their hand luggage or handbags, the airline stresses the importance of carrying any medication so it’s always within reach. A statement on EasyJet‘s website reads: “We do advise you to pack your medication in your hand luggage where possible, especially if it is medication that you may need to take during the flight.”

In an additional note, the airline says: “If you pack medicines in your hold luggage, we do not require a letter from your healthcare practitioner.” It adds: “We’re unable to refrigerate medication on board.”

There are certain types of medication and equipment passengers can bring on board. EasyJet says: “If you need to bring medication with you, please pack it in your cabin bag wherever possible.” A letter from your healthcare practitioner is only required if you are bringing any of the following items on board:

  • Liquids that exceed 100ml.
  • Sharp objects such as needles.
  • Oxygen cylinders and concentrators.
  • Any medical equipment that may be considered as dangerous goods in the aircraft cabin, a list of which can be found here.

EasyJet explains: “The letter should confirm that this medication is prescribed to you and it’s necessary for you to bring the items on board. We do not require a letter from your healthcare practitioner for all other medications and equipment.”

These include gel packs and cooler bags to maintain the temperature of your medication. As well as food and specialist devices such as dialysis machines (subject to size regulations), CPAP machines and nebulisers.

If travelling with medication containing a controlled drug, EasyJet advises passengers to check with their doctor or pharmacist if their prescription contains a controlled drug, as some countries have strict laws regarding these medications. Controlled drugs are medications that are subject to high levels of regulation as a result of government decisions, such as Diazepam, Lorazepam, Codeine or Tramadol.

EasyJet said: “If you need to travel with medicine that contains a controlled drug, please check the embassy rules for the country you’re travelling to, as well as the entry requirements before you fly. You will need to prove your medication is yours, either with a prescription or a letter from your doctor.”

Crutches and walking frames can be brought on board. EasyJet’s cabin crew can store them and return them after landing. Walking frames can be stored on board if space is available, or they will be put into the aircraft hold and returned after landing.

Portable medical equipment can be brought on board in addition to your cabin bag allowance. Portable medical devices must be no larger than 56 x 45 x 25 cm, otherwise they will have to travel in the hold. If you need to carry a small portable medical device, such as:

  • CPAP machines
  • TENS machines
  • Nebulisers
  • Portable dialysis machines

EasyJet said: “Then this may be carried in addition to your cabin bag allowance, provided that it’s no larger than 56 x 45 x 25 cm and that you have informed our Special Assistance Team, at least 48 hours before your flight that you require an additional medical bag for your journey. Non-essential medical equipment which exceeds your cabin-bag allowance will be charged in line with our baggage policy and may need to be placed in the hold.

“If you need to bring several medical devices or a large piece of medical equipment, please contact our Special Assistance team at least 48 hours before your flight so that they can advise you.”

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Global hunger report warns of rising malnutrition and famine risks | Infographic News

Famine was confirmed in two places in 2025 – areas of the Gaza Strip and Sudan – the first such dual confirmation since formal famine reporting began, according to the Global Report on Food Crises (GRFC) 2026.

The annual report, produced by a coalition of 18 humanitarian and development partners, found that acute food insecurity remained widespread in 2025.

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Across 47 countries and territories experiencing food crises, 22.9 percent of their populations – or about 266 million people – experienced acute food insecurity last year, a marginal rise from 22.7 percent in 2024 but nearly double the 11.3 percent recorded in 2016.

INTERACTIVE_FAO_GLOBAL_REPORT_2025_APRIL23_2026-02-1777011588

The proportion of analysed populations facing acute hunger has now stayed above 20 percent every year since 2020. In absolute terms, the number of people affected has grown from 108 million in 2016 to 265.7 million in 2025, having peaked at 281.6 million in 2023.

The GRFC cautioned that the slightly lower headline figure compared with 2024 mainly reflects a reduction in the number of countries covered – from 53 to 47 – rather than any real decline in needs.

 

Famine, catastrophe and emergency

Famine – the most extreme classification under the hunger-monitoring Integrated Food Security Phase Classification (IPC) system – was confirmed in parts of the Gaza Strip and Sudan in 2025. The risk of famine remained in other areas of Gaza, Sudan and South Sudan, and those projections extended into 2026.

According to the IPC, famine is when:

  • At least 20 percent of households face extreme food shortages.
  • Acute malnutrition affects more than 30 percent of the population.
  • The death rate due to starvation or hunger-related causes exceeds two deaths per 10,000 people per day.
INTERACTIVE - Famine Gaza measurement
(Al Jazeera)

Six countries and territories had populations facing “catastrophic conditions”, or Phase 5, the highest level in the IPC’s classification of food insecurity. They numbered 1.4 million people, a more-than ninefold increase since 2016.

The Gaza Strip was the worst affected, with 640,700 people facing famine conditions, equivalent to 32 percent of its population, the highest share recorded globally. Sudan followed with 637,200 people, or 1 percent of its population.

Four other countries recorded catastrophic food shortages among specific groups of people: South Sudan – 83,500 (1 percent of the population), Yemen – 41,200 (0.1 percent), Haiti – 8,400 (0.1 percent) and Mali – 2,600 (0.01 percent).

Additionally, more than 39 million people in 32 countries were in Phase 4, or emergency conditions, representing 3.8 percent of the population analysed, a marginal increase from 2024.

INTERACTIVE_FAO_GLOBAL_REPORT_2025_APRIL23_2026-01-1777011625

Conflict remains the main driver of hunger

Conflict and violence were the primary drivers of acute food insecurity in 19 countries where 147.4 million people were affected. They represented more than half of those facing acute hunger globally.

Weather extremes were the primary driver in 16 countries, affecting 87.5 million people, while economic shocks led in 12 countries, with 29.8 million people affected.

Against that backdrop, humanitarian and development financing for areas facing food crises declined in 2025, falling back to levels last seen in 2016-2017, the report said.

As for 2026, the report said that based on a partial picture as of March, severity levels remain critical in multiple contexts. It added that the escalation of conflict in the Middle East exposes food-crisis countries to direct and indirect risks of global agricultural and food market disruptions.

A generation of malnourished children

An estimated 35.5 million children were acutely malnourished in 2025 across 23 countries experiencing nutrition crises, including just under 10 million with severe acute malnutrition, the most life-threatening form.

A further 25.7 million children suffered from moderate acute malnutrition. About 9.2 million pregnant and breastfeeding women were also acutely malnourished across 21 countries with available data.

Interactive_WorldFoodDay_October16_2025-01-1760613556
(Al Jazeera)

Displacement is concentrated in food-crisis countries

The number of forcibly displaced people in the 46 countries covered fell slightly in 2025 to 85.1 million.

About 62.6 million of them were internally displaced across 34 countries, and 22.5 million were refugees and asylum seekers in 44 countries.

Without a sustained push to address the structural drivers of hunger, the world’s most fragile countries will continue to bear a disproportionate share of the global hunger burden well into 2026, the report concluded.

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Jane Fallon gives fans health update after having second surgery following breast cancer diagnosis

JANE Fallon has given her fans a health update after having her second surgery following her cancer diagnosis.

The author, 65, who is the partner of Ricky Gervais, told fans earlier this month that she was suffering with breast cancer, despite having no symptoms before the diagnosis.

Jane Fallon has given her fans a health update after having her second surgery following her cancer diagnosis Credit: Instagram
The author who is the partner of Ricky Gervais, told fans earlier this month that she was suffering with breast cancer Credit: Getty

Posting a sweet pic alongside her cat Pickles on Instagram, Jane wrote: “Little update. So, my 2nd surgery went well.

“They got the clear margin they need on the original excision, which is great. 

“They did hit a new little patch of precancerous cells on the other side of the new bit they took out but, thankfully, everyone agrees more surgery would be overkill. 

“A huge % of pre cancer doesn’t develop into cancer. 

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“I saw the oncologist today & we’ve agreed the risks of radiation outweigh the benefits in my case.

“Which leaves Tamoxifen (or similar) or wait and see (my preferred option). 

“I’m very nervous about going the drug route, because I know the side effects can be hideous, but I’m taking all the info on board & luckily there’s no pressure to make a quick decision.

“So, all good & I’m just looking forward to getting back to normal.”

Jane’s followers flocked to support her, including author Jojo Moyes who wrote: “Well done for getting through another surgery.

“Wishing you some reassuring news very soon x”

A fan added: “Happy to hear the update and it sounds very positive … yes take your time to decide , & so all the research … as of course you will x”

Another said: “That’s such uplifting news , so pleased your doing well. onwards and upwards x And cats will always upstage.”

This comes just days after Jane slammed a fake obituary that was published online after she was revealed she had cancer.

She said: “I’ve taken the post about the obituary down, because I don’t want people to think I’m upset by it. I’m not. P***ed off yes.

Breast Cancer Screening

Most women will have been told to check their own breasts for signs of lumps and bumps, but after a certain age you’ll be invited for a free NHS breast cancer screening.

You’ll automatically get your first invite for up to three years after you hit 50, as long as you’re registered to a GP surgery.

After that, you’ll be invited every three years until you turn 71.

If you’re a trans man, trans woman or are non-binary, you may be invited automatically, or you may need to talk to your GP surgery or call the local breast screening service to ask for an appointment.

If you have not been invited for breast screening by the time you are 53 and think you should have been, contact your local breast screening service.

But if you’re experiencing symptoms of breast cancer before you reach screening age, don’t wait to be invited – see a GP.

Do this even if you’ve recently had a breast screening.

Read more about screening here.

“But more, I just want people to know that any photos you see of me in hospital, looking sad or with tubes sticking out of me are 100% fake – AI generated.”

Following her recent procedure, Jane told her followers she was feeling “remarkably fine” and in good spirits.

She assured people she wold update them once she had the medical all clear.

“Then 8-10 days wait for confirmation that they’ve got it all & the margins are clear (small % chance of more surgery if not),” Jane wrote.

She has been resting up at home with the support of cat Pickles.

When Jane announced her diagnosis, Jane asked fans not to “panic” and said her prognosis was “excellent”.

She has been with comedian Ricky for more than 40 years after meeting back in 1982.

Jane is the author of 14 bestselling books and has penned titles such as Getting Rid of MatthewGot You BackQueen BeeWorst Idea Ever, and Faking Friends

Jane has been with comedian Ricky for more than 40 years after meeting back in 1982 Credit: X/JaneFallon
When Jane announced her diagnosis, Jane asked fans not to “panic” and said her prognosis was “excellent” Credit: Instagram
Jane is the author of 14 bestselling books such as Getting Rid of Matthew and Queen Bee Credit: Instagram/janefallon2

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Rep. David Scott, a Georgia Democrat seeking his 13th term in Congress, dies at age 80

U.S. Rep. David Scott, a Georgia Democrat and the first Black chairman of the House Agriculture Committee, has died. He was 80.

Scott, who was seeking his 13th term in Congress despite challenges from within his party, was once a leading voice for Democrats on issues related to farm aid policy and food aid for consumers and a prominent Black member of the party’s moderate Blue Dog caucus. But he faced criticism and concerns in recent years because of declining health, enduring a primary challenge in 2024 and facing another one at the time of his death.

Democrats on Capitol Hill praised the longtime lawmaker.

“The news of Congressman Scott’s passing is deeply sad,” House Minority Leader Hakeem Jeffries told reporters on Wednesday.

“David Scott was a trailblazer who served district that he represented admirably, rose up from humble beginnings to become the first African American ever to chair the House Ag Committee,” Jeffries said. “He cared about the people that he represented. He was fiercely committed to getting things done for the people of the great state of Georgia, and he’ll be deeply missed.”

News of Scott’s death came during the Congressional Black Caucus’ weekly luncheon on Capitol Hill. The Black Caucus’ chair, Rep. Yvette Clarke, told lawmakers at the outset of the meeting, according to a person who insisted on anonymity to discuss a private conversation. Many lawmakers in the room, some of whom had served with Scott for decades, were shocked and saddened by the news.

Scott’s death slightly widens Republicans’ narrow House majority going into the thick of this midterm election year.

The congressman was not especially active on the campaign trail in 2026. But he had been dismissive of pressure to retire.

“Thank God I’m in good health, moving and doing the people’s work,” Scott said in 2024.

David Albert Scott was born in rural Aynor, South Carolina, on June 27, 1945, in the era of Jim Crow segregation. He graduated from Florida A&M University, one of the nation’s largest historically Black college campuses — and in office he was an outspoken advocate for federal support of HBCUs. Scott also earned an MBA from the University of Pennsylvania’s Wharton School.

He was already a veteran state lawmaker in Georgia before being elected to Congress in 2002.

Barrow, Brown and Amy write for the Associated Press. Brown reported from Washington.

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Kerry Katona shares new worrying health update after she was rushed to hospital over stroke fears

KERRY Katona has revealed she’s experiencing speech difficulties after she was rushed to hospital over stroke fears.

The Atomic Kitten singer said she was with her partner Paolo Margaglione and her daughter Heidi who noticed that her mum’s face didn’t ‘appear right’.

Kerry Katona has shared a new health update after her recent hospital dash Credit: Getty
The TV personality said she’s suffering with aftereffects following the ordeal Credit: Instagram / @kerryboutique.co.uk

Kerry, 45, was in London at the time of the incident, watching her eldest daughter Molly in a new play, when she fell unwell midway through the performance.

The TV personality was then rushed to hospital in an ambulance where it was treated “as a stroke”.

Although it was later ruled out as a stroke and most likely a result of stress, the mother-of-five said she’s still dealing with aftereffects.

Writing in her New column, she said: “I know I’m talking differently and I know my face looks different after my suspected stroke, but it’s actually loads better.

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Kerry Katona reveals she was rushed to hospital over stroke fears

“It comes and goes.”

Kerry admitted that the terrifying ordeal had sent her anxiety through the roof.

She continued: “I’ve just got to try and not think about it, because I’m the worst hypochondriac in the world.

“It’s awful for my family, I think they’re all fed up and sick of me at this point.

“I have severe health anxiety, so when I start reading all the comments and I start learning all these new things that could be wrong, it makes me truly panic.”

Kerry opened up about the hospital dash earlier this month.

She told the Mirror: “I went to the toilet and noticed my face wasn’t right.

“And Heidi was like, ‘Mum, what’s wrong with your face?’ I started panicking. I discreetly left, went to my hotel and asked to see a doctor. I told the staff, ‘Something’s not right.’”

The mum-of-five was subsequently rushed to hospital in an ambulance.

“I got there, and they said, ‘We’re treating this as a stroke,’ so they blue-lit me in an ambulance from St Thomas’ to King’s College Hospital,” explains Kerry.

“They were shining lights in my eyes while my face and speech were getting worse.

“An hour ago I was watching our Molly in a play and now I’m being treated for a stroke. What the actual f**k? It just shows how quickly things can change.”

She said she felt ‘really scared’ and feared the worst but a stroke was later ruled out after a CT scan.

The Celebs Go Dating star revealed that her health scare was down to ‘delayed stress’ that can affect a person after they’ve ‘found peace’.

Following the incident, Kerry jetted off on holiday to Spain with her family to celebrate Dylan-Jorge’s 12th birthday but said she would see follow-up care when back in the country.

Kerry has Molly, 24, and Lilly-Sue, 23, with ex Brian McFadden; Heidi, 19, and Max, 17, with ex Mark Croft; and daughter Dylan-Jorge (known as DJ), 12, with late-husband George Kay.

Kerry exclusively told The Sun how things have been looking up for her ever since coupling up with new beau Paolo – 12 years her junior.

“Paolo is just a complete one-off,” she said.

“I’ve never met a human being like him. It actually makes me anxious, because I keep thinking it’s just too good to be true. I get emotional talking about him.

“I am so lucky I found him. I feel loved and wanted. I’ve never felt like that. I don’t think I’ve ever really truly been in proper love until I met Paolo. I don’t think I realised how starved I was of affection.

“I wasn’t even looking for a boyfriend or to get married again – I couldn’t think of anything worse. I wanted a pay cheque, exposure and a therapist [from the show]. Then I met him and thought, ‘You’re different.’”

Kerry said it was ruled out as a stroke but was likely the result of stress Credit: PA

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Flu vaccine no longer mandatory for soldiers, says US military chief | Military News

Pete Hegseth says the decision is based on the principle of ‘medical autonomy’ and criticises the mandate as ‘overreaching’.

United States Defense Secretary Pete Hegseth has said that the flu vaccine will no longer be obligatory for members of the country’s military, the latest step under President Donald Trump to shift vaccine policy in the federal government.

Hegseth said in a video shared on social media on Tuesday that the decision was based on principles of “medical autonomy” and religious freedom.

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“We’re seizing this moment to discard any absurd, overreaching mandates that only weaken our warfighting capabilities. In this case, this includes the universal flu vaccine and the mandate behind it,” said Hegseth.

“The notion that a flu vaccine must be mandatory for every service member, everywhere, in every circumstance at all times is just overly broad and not rational.”

The Trump administration has framed vaccine refusal as a matter of personal moral and religious principle, rolling back some policies meant to safeguard against preventable diseases.

Hegseth’s directive allows various military services to request that the mandate be kept in place, giving them a window of 15 days to do so.

The announcement comes after what health officials described as a particularly severe flu season when infections surged in the US. Public health experts have recommended that everyone aged six months or older get an annual flu vaccine.

The second Trump administration has reflected some of the backlash to public health guidelines and mandates that were implemented during the COVID-19 pandemic.

Hegseth himself has called that period an “era of betrayal” for the country’s armed forces. More than 8,400 members of the military were ejected for failure to abide by a 2021 mandate to take the COVID-19 vaccine.

The Trump administration has also rolled back vaccine recommendations in other areas, announcing earlier this year that it would not recommend flu shots and other forms of vaccines for all children. A lawsuit was filed challenging that effort, and the policy was temporarily blocked by a federal judge as the legal challenge plays out.

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Christina Applegate shares health update after reported hospital visit

Christina Applegate is speaking out amid reports of an extended hospitalization.

The acclaimed comedy actor, who was diagnosed with multiple sclerosis in 2021, has been the subject of regular news coverage in the years since her health first began to decline. TMZ on Thursday reported that she had been hospitalized in Los Angeles for undisclosed reasons, leading her friends and fans to extend messages of support.

“Thank you for the outpouring of love and well wishes,” Applegate said Monday in a social media post seemingly referencing such messages. The post included a photo of the actor’s recently released memoir, “You With the Sad Eyes,” and a coffee mug resting on what appears to be a home parapet.

She continued: “Health issues are a constant for me, but I’m a strong chick and I’m getting stronger and better every day. I’m taking a moment to focus on my health, but I’ll be back with more to say soon enough.”

Several of Applegate’s fellow actors offered support in the comments section, with Cheyenne Jackson writing, “Christina, just in case today’s mail got lost: We the public would like to formally submit that we adore you, support you, and RIDE AT DAWN FOR YOU ALWAYS.”

“Days of Our Lives” star Greg Rikaart echoed his sentiment: “Can’t think of anyone the collective culture roots for more than you.”

Applegate’s representative previously declined to comment on the hospitalization reports, telling Entertainment Weekly that the “Married … With Children” alum has “had a long history of complicated medical conditions that she has been refreshingly open about, as evidenced in her memoir and on her [‘MeSsy’] podcast.”

Applegate in March released “You With the Sad Eyes,” detailing everything from her unstable childhood to her decades-spanning acting career and the health issues that have plagued it.

“This book is not cathartic for me — let’s just go there,” Applegate recently told The Times. “I just needed to dump this s— out somewhere. It’s almost like you guys are now my therapists in the world.”

“There’s going to be really f— horrible s— and then we’re going to have fun stuff — because that’s what my editor told me to have (that’s a joke!) — and crap again,” the “Dead to Me” star said. “That’s my life.”



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Gonadorelin: Molecular Signaling, Temporal Dynamics, and Expanding Research Horizons

Gonadorelin, a decapeptide identical in sequence to gonadotropin-releasing hormone, is believed to occupy a foundational position in endocrine signaling research. Since its structural elucidation in the twentieth century, the peptide has served as a conceptual bridge between neurochemical signaling and systemic hormonal coordination within the research model.

Contemporary scientific discourse increasingly frames Gonadorelin not merely as a reproductive regulator, but as a finely tuned molecular signal whose rhythmic release, receptor interactions, and downstream cascades offer insight into broader principles of cellular communication, feedback regulation, and temporal encoding. This article explores Gonadorelin through a research-oriented lens, supporting  its molecular characteristics, signaling properties, hypothesized systemic roles, and emerging investigative domains. The discussion relies on established scientific knowledge while maintaining speculative language appropriate to ongoing inquiry.

Molecular Identity and Structural Considerations

Gonadorelin is a linear decapeptide composed of ten amino acids arranged in a highly conserved sequence across vertebrate species. This conservation has long intrigued researchers, as it suggests evolutionary pressure to preserve both structure and function. From a biochemical perspective, the peptide’s relatively small size belies its extensive signaling reach within the research model.

At the molecular level, Gonadorelin may be viewed as an archetypal neuropeptide, synthesized as part of a larger precursor molecule and subsequently processed into its active form. Its tertiary simplicity allows it to interact with a specific G protein-coupled receptor, commonly referred to as the gonadotropin-releasing hormone receptor. Research indicates that subtle alterations in amino acid composition or terminal modifications may significantly alter receptor affinity, signaling bias, and degradation kinetics. These observations have fueled interest in Gonadorelin analogs as experimental tools for probing receptor dynamics and intracellular signaling selectivity.

Receptor Interaction and Intracellular Signaling Cascades

The interaction between Gonadorelin and its receptor represents a classic model for ligand-receptor specificity in mammalian endocrine research. Upon binding, the receptor undergoes conformational changes that may activate multiple intracellular pathways, including phospholipase C signaling, calcium mobilization, and protein kinase activation. Rather than functioning as a simple on-off switch, Gonadorelin signaling appears to encode information through frequency and amplitude modulation.

Research suggests that pulsatile exposure to Gonadorelin might generate distinct intracellular responses compared to continuous exposure, even when total peptide availability remains constant. This phenomenon has positioned Gonadorelin as a central example in studies of temporal signaling, where timing itself becomes a biologically meaningful variable. Investigations purport that this temporal encoding may influence gene transcription patterns, receptor recycling, and cellular sensitivity over time.

Temporal Dynamics and Rhythmic Signaling

One of the most compelling research properties of Gonadorelin lies in its rhythmic release pattern. Unlike many signaling molecules that operate through steady concentrations, Gonadorelin appears to function optimally through discrete pulses. Scientific inquiry has long theorized that this pulsatility allows the mammalian model to maintain responsiveness while avoiding receptor desensitization.

From a systems biology perspective, Gonadorelin may serve as a model for understanding how oscillatory signals regulate complex physiological networks. Computational analyses and laboratory-based research models have explored how variations in pulse frequency, duration, and interval might translate into differential downstream signaling outcomes. These explorations extend beyond reproductive endocrinology, offering conceptual frameworks potentially relevant to circadian biology, metabolic regulation, and adaptive feedback systems as they prove relevant to mammalian models.

Genetic Regulation and Transcriptional Influence Research

Beyond immediate signaling cascades, Gonadorelin is thought to potentially exert a longer-term interaction with or modulation of gene expression. Research indicates that activation of its receptor may alter transcriptional programs associated with cellular differentiation, hormone synthesis, and receptor expression itself. This layered regulatory architecture suggests that Gonadorelin signaling may participate in both rapid and delayed regulatory loops within the research model.

Epigenetic considerations have also entered the conversation. Some investigations hypothesize that repeated Gonadorelin signaling might influence chromatin accessibility or transcription factor recruitment in target cells. While these concepts remain under active exploration, they underscore the peptide’s potential relevance to developmental biology and long-term cellular adaptation.

Possible Role in Neuroendocrine Integration Research

Gonadorelin seems to occupy a unique intersection between neural signaling and endocrine output. Synthesized within specialized neurons, the peptide appears to translate neural inputs into hormonal coordination. This positioning has encouraged researchers to use Gonadorelin as a proxy for studying neuroendocrine integration more broadly.

Research models have examined how external stimuli such as environmental cues, stress signals, and metabolic states might modulate Gonadorelin synthesis and release. These lines of inquiry suggest that the peptide may function as an integrative node, aligning internal physiological states with external conditions. Such hypotheses elevate Gonadorelin from a single-pathway regulator to a dynamic mediator of cell-wide coherence.

Investigative Implications in Endocrine Research Models

Within laboratory settings, Gonadorelin has been widely referenced as a molecule suited for evaluationg receptor responsiveness, signaling fidelity, and feedback regulation. Its well-characterized sequence and receptor interaction profile make it an ideal benchmark for experimental design. Researchers often employ Gonadorelin to calibrate assays measuring gonadotropin synthesis, second messenger generation, or transcriptional responses.

Beyond traditional endocrine studies, Gonadorelin has found relevance in comparative signaling research. By examining how different cell types respond to identical Gonadorelin stimuli, investigators gain insight into cell-specific signaling architectures and receptor coupling strategies. These approaches may inform broader theories of cellular specialization within multicellular models.

Emerging Hypotheses Beyond Reproductive Signaling

While historically associated with reproductive axis regulation, Gonadorelin has increasingly been discussed in the context of broader biological roles. Some research indicates that its receptor may be expressed in tissues not classically associated with gonadotropin regulation. This observation has led to hypotheses that Gonadorelin signaling might support processes such as cellular proliferation, differentiation, or metabolic coordination in context-dependent ways.

In systems-level analyses, Gonadorelin has been theorized to contribute to network stability by participating in feedback loops that extend beyond a single hormonal axis. These speculative models propose that the peptide’s rhythmic signaling might synchronize multiple physiological subsystems, thereby supporting cellular homeostasis under changing conditions.

Conclusion

Gonadorelin remains one of the most intellectually rich peptides in contemporary biological research. Far from being limited to a narrow endocrine function, the peptide embodies key principles of molecular signaling, temporal regulation, and systems integration within the mammalian model. Its conserved structure, rhythmic signaling properties, and multifaceted intracellular impacts continue to inspire investigation across disciplines ranging from neuroendocrinology to computational biology. Researchers interested in further studying this compound are encouraged to visit Core Peptides.

References

[i] Stamatiades, G. A., & Kaiser, U. B. (2017). Gonadotropin regulation by pulsatile GnRH: Signaling and transcriptional control.Endocrinology, 158(11), 3369–3380.
 https://doi.org/10.1210/en.2017-00425

[ii] Navarro, V. M., & Tena-Sempere, M. (2012). New insights into the control of pulsatile GnRH release.Frontiers in Endocrinology, 3, 48. https://doi.org/10.3389/fendo.2012.00048

[iii] Whitlock, K. E., & Schlarb, J. E. (2019). Is gonadotropin-releasing hormone neurons dispensable for reproductive neuroendocrine function?Journal of Neuroendocrinology, 31(1), e12696. https://doi.org/10.1111/jne.12696

[iv] Flanagan, C. A., & Manilall, J. D. (2017). Gonadotropin-releasing hormone receptors: Structure, ligand binding and intracellular signaling.Frontiers in Endocrinology, 8, 274. https://doi.org/10.3389/fendo.2017.00274

[v] Ohlsson, B. (2016). Gonadotropin-Releasing Hormone and its physiological and pathophysiological roles in relation to the structure and function of the gastrointestinal tract.European Surgical Research, 57(1-2), 22–33. https://doi.org/10.1159/000445717

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Trump signs order to speed research on psychedelics for mental health

April 18 (UPI) — President Donald Trump signed an executive order Saturday to accelerate research for some psychedelic drugs to treat mental health disorders.

Surrounded by podcaster Joe Rogan and veterans, the president signed the order that could lead to use of the psychedelics in controlled, therapeutic settings.

“We’re taking this decision, this decisive step, to confront one of the most urgent public health challenges facing our nation, the mental health crisis,” Trump said Saturday in the Oval Office.

“Today’s order will ensure that people suffering from debilitating symptoms might finally have a chance to reclaim their lives and lead a happier life,” Trump said.

The order directs the Food and Drug Administration to speed its review of new treatments. Trump said the order applies to certain drugs that are already in the “advanced stages of clinical trials.”

Rogan said he sent the president “some information” about the drugs after he heard about them on his podcast, The Hill reported.

“I sent him that information. The text message that came back: ‘Sounds great. Do you want FDA approval? Let’s do it.’ Literally that quick,” Rogan said.

Trump mentioned ibogaine, which has been used to treat post-traumatic stress disorder in other countries. He said the administration would be “opening the pathway” for the drug to be included in the Right to Try Act, which allows terminally ill patients to participate in clinical trials for treatments still under FDA review, The Hill reported. Trump signed that act into law in 2018.

“Under this new program in this administration, drugs can get approved in weeks, not a year or year plus, but in weeks, if they are in line with our national priorities,” FDA Commissioner Martin Makary said at the signing.

“This is an unmet public health need, and there are potentially promising treatments,” Makary said. “That’s why there’s a sense of urgency around this. That’s why we’re doing it now.”

In 2024, 471 U.S. service members died by suicide, and there were 1,515 attempts reported, according to the Pentagon’s Annual Report on Suicide in the Military.

Some of the drugs included are ibogaine; LSD; psilocybin; known as magic mushrooms; and MDMA, known as ecstasy. Trump added that the government had just committed $50 million in additional funding for ibogaine research, The Post reported.

“Federal prohibition of psychedelic medicine in America is over,” said W. Bryan Hubbard, an advocate for access to ibogaine, The Washington Post reported.

Kevin Sabet, who was a White House drug policy adviser over three presidential administrations, disagreed. He said the order will “send the wrong message” and encourages hasty, potentially dangerous research.

“People need to realize there is little to no evidence for most of these drugs and most of the conditions they claim to alleviate,” Sabet, president of Smart Approaches to Marijuana, wrote in a text message to The Post.

Health and Human Services Secretary Robert F. Kennedy Jr. has championed the idea of using psychedelics to help with mental health conditions. On Saturday, he said officials owed it to veterans “to turn over every stone.”

“It’s disturbing to me and to the president that hundreds, in fact, thousands of veterans are having to travel to Mexico or other countries to experiment with interventions that hold great promise,” Kennedy said.

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Gov., Nunez forge a health plan

After nearly a year of often tortuous negotiations, Gov. Arnold Schwarzenegger and Assembly Speaker Fabian Nunez have settled on a plan to extend health insurance to 3.6 million Californians who lack it through a new tax on all employers and tobacco sales, officials said Friday.

The leaders have agreed to ask voters in November to require employers to spend between 1% and 6.5% of their payroll costs on healthcare. The measure would also levy a tax on tobacco sales of at least $1.50 a pack, although it could be as high as $2 a pack, the aides said.

“It’s an incredible plan,” Nunez (D-Los Angeles) said in an interview. “I couldn’t tell you there is one single outstanding issue that is a make-or-break issue.”

Daniel Zingale, a senior advisor to Schwarzenegger, said the leaders “have agreed on the framework of the healthcare reform that will go before voters.”

Nunez’s office on Friday filed a companion bill that contains the details of how the plan would work and scheduled an afternoon vote in the Assembly on Monday, presuming a few details will be resolved over the weekend.

That bill does not contain the taxes or other measures that would provide the $14 billion a year needed to finance the ambitious overhaul and would not take effect unless the ballot measure passes. That puts Democratic lawmakers in the highly unusual position of voting on the plan without being able to assess whether the intricate financing scheme will be adequate. Republicans have already vowed to vote against the measure.

The moves came as Schwarzenegger promised to call an emergency session of the Legislature for early January to make cuts to the state’s budget. The governor’s office estimates the projected gap may reach as high as $14 billion by July 2009, which is threatening to sap political momentum from the healthcare plan.

On Thursday, Senate President Pro Tem Don Perata (D-Oakland) said that while he supported most of the Nunez-Schwarzenegger plan, he intends to delay a Senate vote on the measure until the governor outlines how his proposed budget cuts will affect existing healthcare programs for the poor and disabled

The Nunez-Schwarzenegger plan would require almost all Californians to obtain private medical insurance. Those earning below 2 1/2 times the poverty level — or $51,625 for a family of four — would receive state subsidies to pay for most of their premiums.

Families earning more than that but no more than four times the poverty level — $82,600 for a family of four — would be able to fully deduct any premium costs that exceed 5.5% of their incomes, which translates to $4,543 for a family at the top of that range. There would also be tax credits for people who retire before they qualify for Medicare at age 65 so that they would not spend more than 10% of their savings on insurance.

Under the plan, California employers with payrolls of up to $250,000 a year would have to spend at least 1% on healthcare for their workers. Those that didn’t would pay into a state-run health insurance pool that would help secure coverage for the employees. Companies with payrolls up to $1 million would have to pay 4% and those with payrolls up to $15 million would have to pay 6%. All larger companies would pay 6.5%.

The plan would extend coverage to 800,000 low-income children and many impoverished adults who currently do not qualify for public programs. It would omit about 1 million illegal immigrants as well as another 500,000 people who are poor but either refuse public coverage or cannot document that they are legal residents.

The bill the Assembly will consider Monday would upend the way California’s insurance market works. Insurers would be barred from denying coverage to people because of existing medical ailments and would have to spend at least 85% of premiums on medical care.

Many insurers, including Kaiser Permanente and Blue Shield of California, have supported this approach for months, but the state’s largest insurer, Blue Cross of California, is preparing to fight the ballot measure.

The plan also contains a $2.3-billion tax on hospitals, supported by the industry, that would pay for increased MediCal payments to doctors and institutions that treat the poor. That tax would also qualify California to draw another $2.3 billion from the federal government.

Those involved in the negotiations said the only major piece still to be ironed out is the tax on tobacco. Schwarzenegger and Nunez have been negotiating with the tobacco companies to see if they can craft the provision in a way that will win their acquiescence, if not their support. But aides said they are also still discussing whether $1.50 a pack will be enough to fund the plan, or whether they will need $2 a pack — an amount tobacco industry leaders say they will oppose.

We “don’t think funding expanding programs with a declining revenue source makes sense,” said David Sutton, a spokesman for Philip Morris USA in Richmond, Va.

Perata also expressed major reservations about the tobacco tax, and said that provisions being insisted upon by the tobacco industry, including immunity from civil and criminal lawsuits, would doom the deal.

The California Nurses Assn., which has favored replacing private insurers with a state-run provider of medical coverage, said the bill was being pushed through the Legislature. “Just as with the energy deregulation fiasco, legislators are being rushed into voting in the dark on a sweeping bill with massive loopholes and serious financial ramifications that no one has adequately reviewed,” said Donna Gerber, the union’s chief lobbyist.

Even some supporters of lawmakers’ efforts were worried that the broader political climate would be insurmountable.

Bob Ross, president of the California Endowment, a Los Angeles-based foundation that favors expanded healthcare, cited as obstacles the state’s weakening economy, the budget gap and the continued standoff between President Bush and the Democratic-led Congress about expanding federal health insurance for children.

“When you do the math on that set of realities, it doesn’t bode well,” Ross said. “So it comes as welcome news that the governor and the speaker are fighting and trying to get something done.”

jordan.rau@latimes.com

Times staff writer Nancy Vogel contributed to this report.

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Trump joined by Joe Rogan as he signs order to speed up psychedelic review | Health News

The order calls on the federal government to relax restrictions on psychedelics, including ibogaine, for potential treatments.

United States President Donald Trump has signed an executive order to speed up the review of a handful of psychedelic drugs, including the controversial ibogaine.

Trump was joined by podcaster Joe Rogan during Saturday’s Oval Office event.

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Rogan, considered one of the most influential podcasters in the country, has been a leading proponent of ibogaine, which is derived from a plant that grows in West Africa and has been embraced by some military veteran groups as a treatment for post-traumatic stress.

Speaking at the event, Rogan recounted how he had previously texted information to Trump about ibogaine.

He recalled that the president quickly texted back: “Sounds great. Do you want FDA [Food and Drug Administration] approval? Let’s do it.”

Advocacy groups have long pushed for more research into the possible use of psychedelics to treat an array of issues, including depression.

“Today’s order will ensure that people suffering from debilitating symptoms might finally have a chance to reclaim their lives and lead a happier life,” Trump said at the signing.

“If these turn out to be as good as people are saying, it’s going to have a tremendous impact.”

At one point, the president quipped that he would be open to taking psychedelics himself: “Can I have some, please? I’ll take some.”

But he quickly pivoted away from the joke. “I don’t have time to be depressed. You know, if you stay busy enough, maybe that works, too. That’s what I do,” he said.

Increasing research into psychedelics has proven a rare issue with bipartisan support in the US, where ibogaine and other psychedelics remain banned under the federal government’s most restrictive category for illegal drugs.

Health Secretary Robert F Kennedy Jr had previously pledged to ease access to psychedelics for medical use.

Trump’s executive order calls on the Department of Health and Human Services to direct at least $50m to states that have enacted or are developing programmes to advance psychedelic drugs for serious mental illness.

It also arrives ahead of several actions from the FDA to loosen restrictions.

This week, the agency will issue so-called “national priority” vouchers for three psychedelics, which the agency’s commissioner, Marty Makary, said will allow certain drugs to be approved quickly “if they are in line with our national priorities”.

The FDA is also taking steps to clear the way for the first-ever human trials of ibogaine in the US. Previous research had been stalled by concerns over the drug potentially triggering fatal heart problems.

Ibogaine was first used by members of the Bwiti religion in African nations like Gabon for religious ceremonies.

Rogan’s endorsement helped boost Trump ahead of the 2024 presidential election. He has since publicly questioned the administration’s war with Iran, saying it runs counter to Trump’s campaign pledges.

Also present on Saturday was Marcus Luttrell, a former Navy SEAL whose memoir about his time in Afghanistan, Lone Survivor, was later made into a film.

He praised ibogaine during the ceremony: “It absolutely changed my life for the better.”

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I’m A Celebrity’s Adam Thomas’ health battles amid David Haye’s nasty ‘unwell’ comment

Adam Thomas has been battling a health condition, brought on by an autoimmune disease, which means he struggles to walk and was enduring ‘pretty unbearable’ pain

Adam Thomas has been battling a health condition, brought on by an autoimmune disease, for years. During a conversation on I’m A Celebrity tonight, boxer David Haye will be seen trying to get Adam to take taking part in the Termite Terror, unable to accept that the former soap actor just isn’t feeling up to it.

Trying to sleep, Adam admits it would be hard to get through it today because he is feeling dehydrated, but David is seen raging: “Dehydrated?! We’ve all got the same amount of water! Adam is doing it and that’s it!”

David’s co-stars continually try to remind him that their campmate isn’t feeling well enough to get through it, but he becomes hellbent on trying to force Adam into it. He continues: “When is your top form gonna come? Why aren’t we forcing this dude to go and do it? Coincidentally, every time there’s something to do, he’s not feeling well!”

It is at that point that Scarlett, clearly in despair at the situation developing, says: “Stop it David, he’s not well!” Adam previously said he had been in pain every day since his diagnosis – but he had finally found something that would help.

“I’ve been struggling with this autoimmune disease now for about two and a half years. It’s been tough. I’m not overexaggerating when I say this but literally within two and a half years, every day I’ve been in pain,” he explained.

“It’s difficult but now I feel like I’ve found – because I’ve been on so many different meds and trying so many different things, back and forth from doctor’s and hospitals.” Back in 2024, Adam explained that he could “barely walk” and was enduring “pretty unbearable” pain due to his arthritis. Adam took to Instagram and told his followers: “The pain is pretty unbearable at the moment, it’s as if my whole body is seizing up!! The pain was bad before, but it’s a lot worse now… how why???

“Now I wish I never came off the methotrexate because I would take that pain to this every day of the week! I’ve just started my new medication today which takes 12 weeks to take effect and even then it might not work so am not too sure what I can do to ease the pain until then?? I’ve had my steroid injections and it literally lasted a week …

“Going to check in at the hospital tomorrow to see what pain relief I can get, because I can’t carry on like this!” Arthritis is a common ailment causing pain and inflammation in the joints, according to the NHS. Main treatments include lifestyle changes, physiotherapy, medication, and in severe cases, surgery. However, there’s no known cure.

An orthopaedic surgeon said that arthritis can be “very debilitating” and may appear in unexpected areas. He explained that while people often think of hips and knees being affected, they don’t usually consider the hands.

Talking about the pain which is often overlooked, Dr Tom Naylor said that “when you’ve got arthritis pain in the thumb right there (video below) it affects so much of what you do on a daily basis. And it really is debilitating for people who have this”.

Speaking on BBC Morning Live, he explained arthritis as a term that causes pain, stiffness and inflammation in the joints. He said: “It literally means inflammation of a joint.”

Talking about CMCJ, which stands for Carpometacarpal joint, he said that it was all to do with the “joint down at the bottom of the thumb and what happens is the joint starts to wear away and the cartilage starts to get more and more worn.

“Even a deformity can start to form and it impacts everything that you do with your hands.” Speaking about treatments for this type of arthritis, the doctor said: “With all types of arthritis, we tend to follow was called a stepwise approach to treatment.”

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A vaccine standoff and other key moments from RFK Jr.’s first congressional hearing in months

Health Secretary Robert F. Kennedy Jr. on Thursday faced federal lawmakers for the first time since September as he sought to defend a more than 12% proposed cut to his department’s budget and dodge arrows from angry Democrats along the way.

In his testimony before the House Ways and Means Committee, kicking off an expected sprint of seven budget hearings he’ll attend across congressional committees and subcommittees over the next week, Kennedy emphasized the administration’s work to reform dietary guidelines and crack down on waste, fraud and abuse.

Republicans on the committee praised Kennedy as a “breath of fresh air” and asked him to promote his department’s recent actions. Democrats, who have been furious over Kennedy’s sweeping overhaul of the U.S. Department of Health and Human Services, largely had a different agenda.

They needled Kennedy on what they viewed as the Trump administration’s hypocrisy on fraud, demanded to know why he was cutting budgets for various programs and slammed his efforts to pull back vaccine recommendations and messaging, which they said have caused unnecessary deaths.

Kennedy fired back, often raising his voice as he accused the Democrats of misrepresenting his work and past statements.

Here are three standout moments from Thursday’s hearing:

A standoff over measles

One heated exchange early in the hearing came between Kennedy and Rep. Linda Sanchez. The California Democrat decried recent measles outbreaks across the U.S. and asked Kennedy to answer for the fact that under his leadership, the Centers for Disease Control and Prevention pulled back public health messaging supporting vaccination.

“As a mother, this horrifies me,” Sanchez said. “Did President Trump approve your decision to end CDC’s pro-vaccine public messaging campaign?”

Kennedy repeatedly refused to answer, saying first he wanted to respond to the “misstatements that you’ve made” and later praising the Trump administration’s record on preventing measles, although protections against the disease have eroded in some parts of the country as vaccination rates have dropped.

“That’s not answering my question,” Sanchez said as the two talked over each other.

But Sanchez also got Kennedy, a longtime anti-vaccine activist before he entered politics, to acknowledge that a 6-year-old who died of measles last year in West Texas could have potentially been saved with vaccination.

“Do you agree with the majority of doctors that the measles vaccine could have saved that child’s life in Texas?” she asked.

“It’s possible, certainly,” Kennedy said.

RFK Jr. denies talking about Black children being ‘re-parented’

A fight erupted between Kennedy and Rep. Terri Sewell, a Democrat from Alabama, when Kennedy vehemently denied making remarks he’d said in 2024.

The comments dated back to when Kennedy was a presidential candidate. On the “High Level Conversations” podcast last July, he said, “Psychiatric drugs — which every Black kid is now just standard put on Adderall, SSRIs, benzos, which are known to induce violence, and those kids are going to have a chance to go somewhere and get re-parented to live in a community where there’ll be no cellphones, no screens, you’ll actually have to talk to people.”

“Have you ever re-parented, or parented, I should say, a Black child?” Sewell asked, as her staff held up a poster featuring an abbreviated version of the quote.

“I don’t even know what that phrase means,” Kennedy said. “I’m not going to answer something I didn’t say.”

“You’re making stuff up,” he later claimed.

A recording of the podcast shows he made the comments during a conversation about free rehabilitation facilities he was proposing opening at the time in rural areas around the country.

Health and Human Services spokesperson Emily Hilliard said Kennedy before joining the administration was referring to spaces where young people facing alienation, mental health challenges and despair could get re-parented, which she said was a psychotherapy term for “developing the emotional regulation, discipline, boundaries, and self-worth that may not have been established in childhood.”

For Kennedy and his former party, civility is the exception

Kennedy spent most of his life as a Democrat, the scion of one of the nation’s most famous political families. Both Republicans and Democrats during the hearing began their remarks by expressing their admiration of Kennedy’s relatives, among them former President John F. Kennedy.

But again and again throughout Thursday’s hearing, the fraying of bonds between Kennedy and his former party was on full display as spiteful comments were passed back and forth.

The Health secretary grew defensive and visibly agitated. He repeatedly criticized Democratic lawmakers for not giving him a word in edgewise.

“They’ve all shut me up,” Kennedy said at one point. “They give a little speech that they can go and market, you know, for fundraising, and they don’t allow me to answer the question.”

On a few rare occasions, the exchanges were civil. One representative, Gwen Moore of Wisconsin, used humor to make that happen.

“I promise to give you easy, comfortable questions if you don’t yell at me and hurt my feelings,” she told Kennedy. He promised he wouldn’t.

Swenson writes for the Associated Press.

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‘Check now’ as thousands at risk of important NHS document expiring summer 2026

People are being urged to check theirs as soon as possible before peak season

An alert has been issued by money specialists, as an important document is expected to expire for millions of people in the UK this year. It is raising concerns that large numbers of British travellers could be caught out just as the holiday season reaches its peak.

More than 1.2 million UK Global Health Insurance Cards (GHICs) are due to expire in 2026. Nearly 800,000 are expected to run out during the peak summer holiday months of July to September, according to new Freedom of Information data accessed by PayingTooMuch, a travel insurance comparison site.

The NHS says a GHIC lets you get necessary state healthcare in the European Economic Area (EEA) and in some other countries on the same basis as a resident of those countries. This may be free, or it may require a payment equivalent to that which a local resident would pay.

On the NHS website, it states: “A UK GHIC is free and lasts for up to five years. Apply for your new card through the NHS website. Avoid unofficial websites – they may charge you a fee to apply. The UK GHIC is not a replacement for travel insurance. We advise you to have private travel and medical insurance for the duration of your trip.”

The FOI sent to NHS Business Services Authority also highlights a significant rise in expiring cards this summer. The data shows that more than 290,000 GHICs are due to run out in August alone, coinciding with the busiest period for overseas travel.

In response, a money specialist warns that thousands of travellers could unknowingly head abroad with expired GHICs this summer. While this is a small detail often missed amid holiday planning, it’s one that could lead to serious consequences.

Hannah Mayfield (DipFA), founder of What Is Wealth, says the sheer volume of 2026 expiries could leave many people caught out. She said: “If you fall ill or face a medical emergency, discovering too late that your GHIC is no longer valid only adds stress at the worst possible moment.

“With such a high number of GHICs expiring this year, particularly during the busy summer holiday period, it’s vital that travellers check their card well in advance. It is an easy detail to overlook, but one that could leave you seriously exposed once you are already overseas.”

Mayfield warns that the risks do not stop at travelling with an expired card. The FOI data also shows how expensive medical treatment abroad can become, even when state support is accessible. The highest GHIC/EHIC claim last year exceeded £340,000, while the second highest topped £226,000.

“That is the part many travellers may not fully realise,” explains Mayfield. “While a GHIC can help to access basic state-provided healthcare, it is not designed to cover the full range of issues travellers commonly encounter – from private treatment costs if needed to flight cancellations, lost bags or emergency repatriation to bring you home.”

A GHIC is accepted in most EU countries, plus a few additional countries with reciprocal healthcare agreements. It can reduce your medical costs abroad if you need treatment, but it doesn’t make treatment completely free or cover everything.

You might still have to pay for your treatment upfront and buy prescriptions, which you can then claim back through your travel insurance. If you use your GHIC to pay medical fees abroad and make a medical claim through your travel insurance, some providers waive the policy excess on the medical claim, ultimately saving you money.

Mayfield reminds holidaymakers that travel insurance is an essential part of holiday planning, as a good policy provides protection in areas that the GHIC does not. When choosing a policy, she advises checking that cancellation cover matches the full cost of your holiday and ensuring it is tailored to your health needs, destination, and excursions. Comparing travel insurance is a good way to find cover that suits you and the type of trip you are taking, especially if you have with pre-existing health conditions.”

With so many GHICs expiring this year, experts recommend travellers check their card and travel insurance at the same time they book the trip. Renewing early is particularly important if your card expires within six months of your trip, as leaving it too late can lead to complications if treatment is needed overseas.

“You can apply for a free GHIC directly from the official UK government website. All family members should have one in their name. You’ll need your UK address and some basic personal details and usually it will arrive within 7-10 working days.

“Be wary of bogus sites asking you to pay for a GHIC as you don’t need to, they are free,” she adds. Mayfield urges travellers to “check their GHIC now, don’t wait until the airport to discover it has expired.”

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