Health

Miranda Hart reveals why she signed up to Celebrity Traitors after health issues

Miranda Hart has explained why she decided to sign up to Celebrity Traitors, which comes after years out of the spotlight as she dealt with a series of health struggles

Miranda Hart has explained why she decided to sign up to Celebrity Traitors following her “long term ill health issues.” The comedienne, 53, is best known for fronting her eponymous sitcom in the late 2000s but took a break from the spotlight after becoming increasingly unwell.

The TV star previously told how she had suffered a “tick-borne illness” while living in the USA as a teenager. At one point, she was diagnosed with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome, before eventually being diagnosed with Lyme Disease in 2020.

The Celebrity Traitors will mark Miranda’s first mainstream television appearance in six years, and she has now explained that she jumped at the chance to take part.

She said: “My decision making in life generally, and certainly work, is follow the joy. I haven’t done much TV work for a long time, having only recently come out of long-term ill health issues and when I was offered this, my whole body sort of relaxed, I smiled, and I just wanted to jump about like a schoolgirl with joy.

“It’s just fun. It’s outdoors, it’s games. All the stuff I love. It’s play basically. And I’m passionate about encouraging people to play more generally, and this game is that in spades.

“It’s a brilliant television show – the only flaw in taking part is that as a fan of the show it will be less fun to watch it with myself in it!”

Despite her new lease of life, the former Call the Midwife star, who secretly got married in late 2024, is still living with elements of her illness and is struggling to a point but has been able to manage her symptoms and insisted she felt well enough to join Claudia Winkleman’s hit BBC game show.

She added: “I’m still living with elements of ME, and that brings fatigue and pain to manage, but I have come to a point where I feel well enough to step out, and that’s also partly why I’m doing this.

“The joy of mucking about on television again will hopefully outweigh some of the challenges. And I think it will be challenging on my body, so it’ll be interesting, and it’ll take some courage as this is a big next step.

“When you live with a chronic illness, it’s invisible, so people don’t know that you’re sitting there in pain. But then it reminds you that everybody’s got their thing. So, I’m also really looking forward to making friends and looking after each other and hopefully they can carry me up a hill or whatever we’re going to have to do!”

Miranda, who will appear alongside the likes of Little Mix singer Leigh-Anne Pinnock, Coronation Street legend Julie Hesmondhalgh, and Love Island host Maya Jama, even teased that there could be a nod to her sitcom past.

She added: “When someone said on Instagram, “Oh, I hope you gallop in the castle,” I foolishly replied, Right, I now take that as a dare.” So that was idiotic of me.

“I will have to at some point gallop down a corridor. I’ll gallop when no one’s watching…or who would be the best person to encourage to gallop?

“I don’t know. I mean, Kenny probably doesn’t even know who I am. So, if I could get him to gallop…I could get a new generation galloping.”

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BBC radio star quits after 45 years on air with emotional statement about ‘hiccups in his health’

A MUCH-LOVED BBC radio star has quit after 45 years on air.

Roy Noble, 83, revealed he would be hanging up his mic as he shared an emotional statement with his listeners about “hiccups in his health“.

Roy Noble has quit BBC Radio Wales after 45 years Credit: BBC
Roy is a popular presenter on the Welsh airwaves Credit: Alamy

The Welsh-native is stepping down from his job at BBC Radio Wales, where he has been broadcasting since the 80s.

Roy also revealed when his last day on air would be, in an emotional post to fans called “A Letter from Roy Noble”, that was shared on social media.

“My dear friends, compatriots and fellow travellers,” the veteran broadcaster penned.

“After a great deal of thought, I’ve decided that next year will be the right time for me to step away from my Sunday programme on BBC Radio Wales.

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“By the time I present my final show in March 2027, I will have spent 46 wonderful years with BBC Wales. It’s been the privilege of a lifetime.”

Continuing, Roy said: “Radio has changed enormously over the years. Wales has changed too. But one thing has remained constant and that’s the privilege of being welcomed into your homes and lives.

Roy has been a BBC broadcaster since the early 80s Credit: Shutterstock
The star penned an emotional statement to his listeners revealing he was retiring Credit: Alamy

“The signs that retirement was approaching may have included my growing suspicion that ‘apps‘ were invented purely to confuse me. The odd hiccup in health has sent signals too.

“But the truth is I’ve simply reached a point where it feels right to begin a new chapter.

“After all, November will mark 84 of my years of yore. Apparently, 63 is the sweet spot or happiest age to retire so I’ve added a few furlongs to that.”

Roy ended by saying: “But for now, I simply want to say a heartfelt thanks to you all. It’s been an honour.”

Before finding fame on the airwaves in the early 80s, Roy was a teacher, but he left to pursue his passion for radio.

The presenter was an instant hit, and over the years hosted a number of different shows for BBC Radio Wales.

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Eighties stars The Krankies now after ‘swinging’, health battle and ‘new appearance’

The Krankies – Scottish comedy duo Ian and Janette Tough – were a huge hit on TV in the 1980s, but Janette’s health battle sadly forced Wee Jimmy Krankie to retire permanently

For a generation of TV viewers, few catchphrases trigger nostalgic memories of anarchic 1980s television quite like “Fan-dabi-dozi!” From the late 1970s through to the 1990s, Ian and Janette Tough – the real-life husband and wife duo behind iconic double act The Krankies, who coined the catchphrase – were titans of light entertainment.

Playing a long-suffering dad and his naughty son, Wee Jimmy Krankie, the pair – now both 79 years old – were staples of Saturday night prime shows and children’s TV.

After shooting to stardom on the Royal Variety Performance in 1978, they became household names on programmes like Crackerjack before landing their own series, from The Krankies Klub to The Krankies Elektronik Komik.

A TV resurgence followed in the 1990s when they featured on Dawn French and Jennifer Saunders‘ TV programmes and also starred in a number of pantomimes.

But after several decades at the top, the pair eventually stepped away from the spotlight, leaving a legion of fans wondering what came of the beloved Scottish duo.

Speaking to the Mirror seven years ago, the couple refuted claims from friend Christopher Biggins that political correctness had brought an end to their innuendo-laden panto performances.

Instead, they revealed that medical issues had sadly forced Wee Jimmy to hang up his school uniform for good.

“I was diagnosed with osteoporosis three years ago,” Janette disclosed, then aged 73. “My back’s not good and I can’t do as much as I used to. So, when Ian and I went off on a Caribbean cruise to celebrate our golden wedding last month we decided it’s time to put our feet up.”

The pair had accidentally courted controversy in 2017, during their run in Dick Whittington alongside close friend John Barrowman. “One woman called it smutty” Janette recalled. “We did a scene in bed with John. Wee Jimmy said ‘I can feel your Tinkie Winkie’ and pulled out a Teletubby. Then John said ‘No – this is MY Tinkie-Winkie’ and pulled out a big one.”

But they denied longstanding ‘swinging’ rumours in the Mirror’s interview, with Ian explaining: “It was never orgies or wife-swapping parties or swingers’ clubs. We just had a bit of a wild spell when we had lots of fun – our Dirty Thirties.”

Janette continued: “We were doing a revue act in 1981, which featured a magician who had a leopard called Scorpio in his act.

“He had a lion tamer called Rocky and an assistant called Angie – so I had a little ding-dong with Rocky and Ian did the same with Angie. Ian used to joke that I’d come home smelling of leopard while he’d get back with glitter on his bits. We had an anywhere, anytime attitude to sex but we each knew what the other was doing.”

Despite announcing their retirement in 2019 – with Janette also still feeling the lasting effects of a horrific pantomime fall in which she fractured her skull in the early noughties – the pair have continued to make occasional TV appearances.

And fans were delighted last year when the pair unexpectedly popped up in the remastered version of the classic 90s video game Tomb Raider.

A framed pictured of the pair was seen hanging on an office wall as Lara meet the editor of The Times before combing through the newspaper archives.

Reacting to the unexpected appearance, Janette joked to The Scottish Sun: “She did well to dig us up – we’ve been retired for years now.”

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DR Congo begins Ebola vaccination trials for frontline health workers | Ebola

DR Congo is rolling out vaccine trials for health workers at the centre of the country’s Ebola crisis. Health officials hope the Ervebo vaccine, used in previous outbreaks, will be effective against the current strain.

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DR Congo rolls out Ebola vaccine for health workers as death toll rises | Ebola News

50,000 frontline staff to receive a jab for a different Ebola strain, with 20,000 enrolled in a one-year clinical trial.

Health workers in parts of the Democratic Republic of the Congo (DRC) have begun to receive a vaccine that many hope will provide a level of protection against the Ebola virus.

The vaccine rollout started on Saturday in Bunia, the capital of Ituri province in the northeastern DRC. Ituri is the epicentre of the fastest-growing outbreak of Ebola in history.

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The provincial governor, Major-General Gaby Kasongo Mulumba, said health workers there “are particularly exposed and deeply involved in the response”.

The operation, backed by the World Health Organization and Doctors Without Borders, known by its French initials MSF, will also target North Kivu, where cases have been rising sharply, health authorities said.

Some 50,000 health and other frontline workers will be injected with the Ervebo vaccine, which was developed for use against the more common Zaire strain.

Its effectiveness against the current Ebola strain caused by the Bundibugyo virus will be monitored in 20,000 recipients for up to one year.

Clinical trials are ongoing to find a licensed vaccine for the latest outbreak, which has no licensed vaccine or proven treatment.

“We don’t know to what degree it might be effective against the Bundibugyo strain,” Steve Ahuka, a Congolese official who is part of the health task force against the Ebola outbreak, said.

Dr Jeannot Elua said at a health facility in Bunia the vaccine was “beneficial”.

“We healthcare workers don’t really have a choice. We are going to receive it,” he told the Associated Press news agency. “Some people here had already received the previous vaccine. I received it myself, because it was mandatory.”

WHO experts have said that early data on the Ervebo vaccine, notably from animal trials, suggested it could offer some protection in the current outbreak.

The virus has killed at least 3,639 and infected some 7,541 people since May. Some 1,823 people have recovered, according to the latest figures from local authorities.

Workers at the Ceca-20 cemetery in Mongbwalu, Ituri province, Democratic Republic of the Congo, on July 14, 2026, as aid agencies intensify efforts to contain an Ebola outbreak caused by the Bundibugyo virus
Workers at the Ceca-20 cemetery in Mongbwalu, Ituri province, Democratic Republic of the Congo, on July 14, 2026, as aid agencies intensify efforts to contain an Ebola outbreak caused by the Bundibugyo virus [File: Gradel Muyisa Mumbere/Reuters]

The WHO said in August that 70,000 doses of Ervebo were approved for use in the DRC.

The vaccine is being used under a compassionate-use programme, which allows a medical product to be used in a serious disease situation even though it has not been specifically approved for that particular use.

While WHO officials have cited “encouraging signs” that transmission may be slowing, MSF warned on Friday that there is no clear evidence the epidemic is coming under control.

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Israeli strike on motorcycle kills Palestinian in Gaza City, injures child | Gaza News

Separate attacks struck central refugee camps as officials warned Gaza’s health sector faces total collapse.

An Israeli strike on a motorcycle has killed one Palestinian and injured others, with one child in critical condition, reports the Palestinian Wafa news agency.

The air strike targeted the vehicle in the Sheikh Radwan neighbourhood, west of Gaza City, on Friday. Ongoing Israeli strikes on the besieged enclave have killed at least 1,381 people since the ceasefire was announced in October 2025.

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Israel has killed at least 73,795 people and wounded 174,869 others since the start of its genocidal war in October 2023.

On Friday, the Israeli army also opened fire in the Nuseirat and al-Bureij refugee camps in the central Gaza Strip, reports Wafa. The attacks on tents sheltering displaced people have resulted in multiple injuries.

Earlier this week, an Israeli “double-tap” air strike killed a paramedic and a 15-year-old schoolboy in Gaza City. Israeli forces claimed they were targeting Hamas operatives.

Last month, UNICEF found that, on average, one child is killed a day by Israel.

Families are now confined to about a third of the enclave, sheltering among destroyed buildings, rubble and uncleared waste, the agency said.

A Palestinian woman carries a girl past a blood stain on the ground after an Israeli drone strike on a cafe in al-Bureij camp, central Gaza Strip, on September 16, 2026
A Palestinian woman carries a girl past a blood stain on the ground after an Israeli drone strike on a cafe in al-Bureij camp, central Gaza Strip, on September 16, 2026 [File: AFP]

On Wednesday, a previously damaged building collapsed in Gaza City, killing at least 21 people, including 12 children. The Palestinian Civil Defence agency in Gaza struggled to recover bodies from under the rubble due to Israel’s severe restrictions on heavy equipment.

The Health Ministry warned on Wednesday that Gaza’s health system was on the verge of “total collapse” as Israel continues to limit the amount of medical aid and fuel permitted to enter the enclave.

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Sweden’s left-wing opposition leader begins efforts to form government | Government News

Magdalena Andersson will likely face several challenges as she tries to get Sweden’s other left-wing parties to unite.

Sweden’s opposition leader has officially begun talks to form a coalition government after the country’s left-wing bloc won a slim majority in last week’s election.

Magdalena Andersson, leader of the centre-left Social Democrats, was asked by Parliament Speaker Andreas Norlen on Friday to begin efforts to form a new government.

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Norlen’s request follows the resignation of centre-right Prime Minister Ulf Kristersson, who stepped down on Thursday after the general election result was confirmed.

“I have now been tasked with exploring the possibility of forming a government. A task I undertake with great humility and will act constructively to put together a new government,” Andersson said in a statement posted on Instagram.

“My approach to the work that is now taking place is that all political forces now need to put party tactics aside and put Sweden and the Swedish people first.”

Andersson will likely face a series of challenges as she tries to persuade Sweden’s other left-wing parties to unite and form a new administration. The left-wing bloc won 176 of Parliament’s 349 seats in last week’s vote, securing a razor-thin majority of three seats.

Andersson is expected to seek the support of three other left-wing parties: the Greens, the Centre Party and the Left Party.

The socialist Left Party says Andersson will have to award some of its MPs cabinet posts to win their support. However, the liberal Centre Party insists it will not support such a government.

Andersson has until September 28 to form a government. If she fails, Kristersson, whose centre-right bloc won 173 seats, will try to form a coalition.

Coalition and minority governments are common in Sweden because the country has two major left- and right-wing blocs, both of which contain four parties.

The process of forming a government following the 2022 election took more than a month.

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California health clinics accuse influential union and its leader of racketeering in civil lawsuit

The California Primary Care Assn. and five clinics filed a civil lawsuit in federal court Friday accusing SEIU-United Healthcare Workers West and its president, Dave Regan, of racketeering and using ballot initiatives to “shake down” community health centers.

The association alleges that Regan and his union orchestrated a “multi-year campaign of coercion, threats, and economic pressure” to “extort” what the lawsuit describes as “valuable property rights” and “labor-organizing terms” from CPCA and the health centers the association represents in California, according to a copy of the complaint obtained by The Times.

The suit says Regan pushed Proposition 44, which if approved by voters in November will restrict spending at nonprofit community health clinics, as political leverage against the industry. Regan then offered to call off the measure if CPCA agreed to support the union’s efforts to unionize 25,000 industry workers, the lawsuit states.

In the complaint, CPCA estimates that 25,000 new union members would generate $2.37 million in monthly revenue from dues paid to UHW.

“This is about Dave Regan and UHW in particular adopting a strategy to create harmful legislation and harmful ballot initiatives to force people to the table to negotiate favorable agreements that will benefit them financially and then when those agreements don’t go through, they allow these initiatives to go through to create punishment for the organizations that can’t come to terms, and then they keep coming back, over and over and over again,” said Brandon Thornock, chief executive of plaintiff Shasta Community Health, echoing claims in the lawsuit.

“It’s a complete waste of resources and it’s amoral.”

A spokesperson for UHW did not immediately respond to a request for comment on the lawsuit. In an interview in July, Regan denied asking the clinics to support his unionization efforts in exchange for dropping Proposition 44.

“We wanted to construct a relationship with the clinic association that prioritized appropriate funding of the community clinics in California, including restoring the healthcare cuts that were introduced by the ‘One Big [Beautiful] Bill,’” Regan said previously. “It was a strategic relationship where we’re working in a mutually cooperative way to properly fund the healthcare system to respect workers, and they were not interested in that.”

Regan is a powerful figure in California politics who has a history of using the ballot box to try to force the healthcare industry to unionize. The union leader has come under scrutiny this year over claims about his extreme political tactics, intimidating behavior toward and threats against women, and an allegation of assault more than 15 years ago, all of which he denies.

Regan is also the architect of California’s billionaire tax, a proposal on the November ballot to apply a one-time 5% tax on the net worth of billionaires that has splintered labor and divided Democrats.

The CPCA lawsuit, in the federal court in the Eastern District of California, alleges that Regan’s political tactics are not designed to win initiatives, “but to subjugate and terrify.”

The union, the lawsuit states, has filed dozens of punitive ballot measures in California “targeting hospitals and dialysis providers with the implied threat or directly stated purpose of coercing health care providers into acquiescing to their union organizing or bargaining demands.” UHW has spent over $216 million, the suit says, on measures to “harm patients, destroy services, and drive providers out of business.” The vast majority of the UHW-backed measures have been withdrawn, usually after the industry agrees to concessions, the suit states.

“No other singular entity or individual has engaged in such widespread corruption of California’s initiative process,” the suit states.

Proposition 44 requires that community clinics spend 90% of revenue on patient services, which Regan has said ensures that money is aligned with the mission of the health centers.

CPCA and health centers say restricting the funding would dramatically reduce money for other essential services and leave some clinics at risk of closing their doors.

The CPCA lawsuit alleges that Regan’s demands on Proposition 44 were sent in an email in January from a legislative staff member on behalf of the union. The offer, presented as a joint submission from UHW and two union affiliates, included a requirement that community health centers “hold elections for at least 5,000 employees in each of five years the agreement would be in effect, resulting in elections for 25,000 employees over the five-year period.”

The complaint says the email also disclosed that UHW said it would drop the initiative if CPCA agreed to the terms.

“The e-mail unambiguously shows that UHW and the Union Affiliates — bullied and instructed by Regan — agreed and intended to participate in an endeavor to abuse the ballot initiative process to extract valuable labor concessions from CPCA and CHCs, in violation of federal and state law,” the complaint states.

Negotiations to withdraw the measure fell apart on June 24, the day before the deadline to rescind initiatives from the statewide ballot.

The lawsuit alleges that the union offered a new deal that same day.

“UHW would withdraw the Clinic Penalty Initiative if, in exchange, CPCA reversed its opposition to UHW’s billionaires’ wealth tax initiative and took the funds it raised to oppose the Clinic Penalty Initiative and instead used that money to assist UHW in passing its wealth tax,” the lawsuit alleges. “The next morning, Regan, through an intermediary, offered the same ‘deal.’ CPCA refused to entertain such discussions.”

The lawsuit states that California’s community health centers served 6.7 million people in 2025 and 67% are enrolled in Medi-Cal, state subsidized healthcare coverage for low-income Californians. In many rural areas, health centers are sometimes the only source of primary care.

Thornock said Shasta Community Health has patients who travel more than an hour to get care and provides a program that transports them to health facilities. Under Proposition 44, the program would not be considered patient services.

“It was designed to create for us what becomes an existential crisis in many cases,” he said.

The CPCA lawsuit states that Regan and the union began seeking to extort unionization from nonprofit hospitals through ballot measures in 2011 and used the same strategy to try to grow their membership among dialysis center workers beginning in 2017. In early 2022, they began targeting CPCA and health centers through legislation, the lawsuit stated.

The suit also alleges that Regan and UHW are in violation of a California law that prohibits a proponent of a ballot initiative from seeking, soliciting, bargaining for, or obtaining any money or a thing of value from any person or entity for abandoning or preventing an initiative from moving forward.

A week before the lawsuit became public, The Times reported that independent investigators hired by SEIU found in a report that Regan had tried to “extort” an SEIU state council endorsement of the billionaire tax from other California union leaders. An outside law firm that investigated internal charges against Regan found that he suggested to David Huerta, then president of SEIU California, that the state council could be investigated for “governance issues” if the council did not endorse the billionaire tax on the November ballot. The state council later voted to remain neutral on the measure.

The law firm’s investigation, which was paid for by Service Employees International Union, substantiated an allegation that Regan threatened Tia Orr, executive director of SEIU California, over the council’s position on the ballot measure. The SEIU probe found an allegation that Regan also assaulted one of Orr’s predecessors in the job, Courtni Pugh, in 2009, to be credible.

A second investigation conducted by an outside law firm hired by SEIU California found sufficient evidence to substantiate a complaint that Regan bullied Jessica Bartholow, the council’s government relations director.

In interviews with investigators hired by the union and with The Times, Regan admitted to swearing at a staff member for SEIU California and adamantly denied bullying, threatening and assaulting women or seeking to force the state council to back his measure.

Regan remains in his job and alleges that he’s being unfairly targeted over his advocacy for the billionaire tax. SEIU, the national umbrella organization that represents local SEIU affiliates, has not taken any disciplinary action against him while an internal administrative review process moves forward.

Sources involved in negotiations over the billionaire tax said Regan also asked for concessions to grow his union in exchange for rescinding the measure from the ballot this year, which The Times previously reported.

Regan’s list of demands included union contracts with two private hospitals and a health clinic, an organizing neutrality agreement with healthcare clinics statewide, recognition of his union from dialysis clinics and for billionaires to remove measures they launched in response to his tax, according to two sources familiar with the talks who were granted anonymity to share details of the discussions.

The union leader called the allegation “categorically false” and denied that he asked for concessions for his union in exchange for removing the billionaire tax from the ballot.

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Pennsylvania seeks CDC help amid dispute over US measles deaths | Health News

Pennsylvania has asked the United States Centers for Disease Control and Prevention (CDC) for help containing an expanding measles outbreak that has seen several people die, but says it will withdraw the request unless the federal agency recognises four measles-associated deaths reported by the state.

The CDC, however, said it has not been properly notified of any such request.

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The US is currently seeing the worst measles outbreak in the country since 1991, with several deaths over the last couple of years. Measles was declared eliminated in the US in 2000, but has made a comeback in recent years, which some have linked to a rise in vaccine scepticism. The US state of Pennsylvania has been hit especially hard.

In a letter sent to CDC Director Erica Schwartz on Wednesday, Pennsylvania Health Secretary Debra Bogen said the state had begun the process of requesting emergency assistance from the CDC, known as an Epi-Aid.

“The CDC’s choice not to publicly recognize the deaths undermines our response,” Bogen wrote. “For this reason, if CDC is unable to transparently and accurately communicate information about those measles-associated deaths, the Department will respectfully rescind our request for a CDC Epi-Aid.”

However, in a statement to Al Jazeera, Grace Davis Jamison, press secretary for the US Department of Health and Human Services (HHS), said that the CDC had not received Pennsylvania’s request through its normal channels and that federal outbreak assistance was separate from how the agency tabulates deaths.

“CDC will not allow [Pennsylvania Democratic] Governor [Josh] Shapiro to politicize this process. We owe the American people accurate, consistent, and transparent public health information,” Jamison said. “CDC will not submit to political blackmail that conditions critical public health assistance. The people of Pennsylvania should never be used as leverage in a political dispute over how deaths are classified.”

Disagreement grows as Pennsylvania’s measles outbreak spreads

The dispute over the deaths began in August, when Pennsylvania reported that two unvaccinated people died of measles in Lancaster County, which is located in the South Central part of the state. Lancaster is considered the centre of Pennsylvania Dutch Country and home to the nation’s oldest Amish and Mennonite communities. Both communities have under-vaccinated populations.

The CDC initially included the deaths in its national tally, but subsequently removed them after Health Secretary Robert F Kennedy Jr questioned whether measles had caused or contributed to the fatalities. The agency said at the time that available information did not establish whether measles caused or contributed to the deaths.

Pennsylvania continued to stand by its determination.

The outbreak has spread well beyond its initial epicentre in Lancaster County. On September 13, a county coroner reported that a 40-year-old woman had died from complications associated with measles. The state later confirmed the death as measles-associated and announced two additional deaths on September 15. All four people were unvaccinated, according to the state.

The state reported 393 cases across 28 counties when the first two deaths were announced on August 25. Pennsylvania now reports 731 confirmed cases across 38 counties and 141 hospitalisations. Of those reported cases, only four people, or less than one percent, are vaccinated.

What are officials arguing about?

The disagreement between Pennsylvania and the CDC centres on the distinction between a “measles-associated” death versus a death “caused” by measles. Pennsylvania uses “measles-associated” under its state surveillance definition, while HHS said it is working with the Council of State and Territorial Epidemiologists to establish a standardised definition for measles deaths.

Infectious disease experts warn that the dispute over how to classify the deaths puts the CDC at odds with a long-standing approach to tracking the consequences of measles. Matthew Ferrari, director of Pennsylvania State University’s Center for Infectious Disease Dynamics, told Al Jazeera that “measles-associated” death has long been a standard used by the World Health Organization and CDC.

“It’s the most useful distinction because it is a case that could have been prevented by a measles vaccination, or by early detection and isolation,” Ferrari said. “Measles is severely immunocompromising, so it is very often a secondary infection that is the ultimate cause of death.”

Experts say the CDC’s dispute with Pennsylvania risks distracting from efforts to contain the outbreak. Dr Andrew Pavia, spokesperson for the Infectious Diseases Society of America and professor at the University of Utah, told Al Jazeera the distinction should not be controversial.

“The impact, though, is confusion for the public and erosion of trust in the ability of CDC staff to communicate to the public without political interference,” Pavia said.

HHS said federal outbreak assistance and national mortality reporting are separate processes and rejected the idea that the two should be linked.

How would an Epi-Aid help Pennsylvania?

An Epi-Aid is a CDC mechanism for providing rapid, short-term assistance during an urgent public health problem. The CDC says Epi-Aids generally last one to three weeks, during which they deploy Epidemic Intelligence Service officers to analyse epidemiological data, evaluate surveillance systems, and recommend measures to control and prevent the spread of disease.

The requesting health authority retains overall leadership of the investigation, while CDC personnel provide technical assistance, including epidemiological expertise and access to laboratory resources.

“The most important thing for an effective response is communication and trust,” Ferrari said. “It is important for all partners to agree on the foundational elements of the problem and the metrics for evaluating the severity of the problem.”

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Third person dies from malaria in cluster near Germany’s Frankfurt Airport | Health News

Frankfurt grapples with a rare malaria outbreak tied to air travel, marking three deaths in recent months.

A third person has died from malaria after a recent cluster of cases linked to Frankfurt Airport, in what German officials have described as an extremely rare air-traffic-related ⁠outbreak of the tropical disease.

In a statement on Thursday, city administration said the person died at Frankfurt hospital and was one of two infected residents living in the Schwanheim district, in the immediate vicinity of the airport.

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The two new malaria cases in the neighbourhood had been reported on Tuesday.

“Both individuals ‌had become infected with the malaria-causing parasite Plasmodium falciparum, even though they had not travelled to a malaria-endemic region and had not worked at the airport,” the statement said.

According to the city’s public health department, the two newly infected people contracted the disease from a mosquito flown into Germany on an aircraft or in luggage.

Six Frankfurt airport workers had contracted malaria tropica, the most dangerous form of the disease, in July, authorities said. Two later died.

Malaria is a potentially life-threatening mosquito-borne disease that is extremely rare in Germany.

The malaria parasite is spread between ⁠humans by some types of mosquitoes, but not through direct human-to-human contact.

Frankfurt Airport operator Fraport said it set up traps to catch ⁠mosquitoes and sent the insects to a laboratory in Antwerp in Belgium in July and August, but ‌results were not available yet.

Health authorities have warned doctors near the airport to consider malaria in patients who come in with a fever.

Airport workers and residents have been urged to seek medical advice in case they display symptoms including fever, chills, headaches, confusion, seizures and breathing difficulties.

An airport spokesperson said local public health authorities had the power ‌in ‌principle to order airlines to disinfect aircraft.

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Trump administration has cut or frozen $177 billion in grants across every state, analysis shows

The Trump administration has cut or frozen up to $177 billion in federal grants since the president took office for his second term, according to a tracking tool released Wednesday by a pro-democracy nonprofit and a group of researchers and scientists.

The cuts affected all 50 states and the District of Columbia, with health, nutrition, the environment and disaster relief making up the largest share of cuts, the States United Democracy Center and Grant Witness organization found.

Among the grants that were eliminated, frozen or delayed were ones related to maternal health in Michigan, education research in Mississippi and assistance to minority farmers in Iowa, the researchers found. California, Texas, New York, Illinois and North Carolina saw the highest amounts of interrupted grant money. The tracking tool is called Lost Funds.

“By bringing thousands of funding disruptions from the Trump administration together in a publicly accessible, verified database, Lost Funds puts the magnitude of their impact on full display,” Scott Delaney, co-founder of Grant Witness, said in a statement.

The $177 billion finding represents nearly 10% of federal discretionary spending, the groups said.

The tracker’s organizers said the disrupted grants were beyond the kind of cuts that typically happen when administrations change.

“Lost Funds shows the extraordinary scale and real human impact of these disruptions, and how states are once again on the front lines protecting their residents,” said Kelly Rader, States United Democracy Center’s research director.

In some cases, courts have ruled against the administration’s grant funding cuts.

The new tool, which is being made available for public use, relies on data from USASpending.gov, an open data source of federal spending information, according to the groups’ methodology. They said the tracker would be updated regularly as the administration takes new action and lawsuits move through the courts.

States United bills itself as a nonpartisan group dedicated to the rule of law and free, fair, secure elections. It was co-founded by Norm Eisen, an attorney who has been involved in prominent lawsuits against the Trump administration, including over the Kennedy Center. Eisen left States United in 2021.

Grant Witness is a group of scientists, researchers and attorneys who document how funding is changing under President Trump’s administration.

A message seeking comment on the analysis was sent to the White House.

Catalini writes for the Associated Press.

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Is US health care too broken to cure cancer? | Health

The US has poured billions into cancer research, yet it remains one of the country’s biggest killers. Ted Okon, executive director of the Community Oncology Alliance, tells Al Jazeera’s ‘This is America’ that even with a cure, the US wouldn’t be able to treat everyone.

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Arab News | Health resilience and the future of society

During a recent visit to the Shizuoka Cancer Center, a leading medical and research institution in Japan’s Shizuoka Prefecture, I found myself confronting two realities at once.

The first was an impressive expression of modern medicine: advanced treatment, exacting research and an institution seeking to connect clinical care with pharmaceutical innovation. The second was quieter but more powerful. Nearly every patient I passed was facing cancer and beside most stood a relative whose life had also been changed by the diagnosis.

A hospital may contain some of humanity’s most advanced knowledge. It also contains some of its oldest fears.

In such a place, medical excellence is anything but an abstraction. In a hospital, every scientific advance eventually arrives at one person in a vulnerable moment. Every diagnosis enters a life filled with memories, relationships, responsibilities and hopes. Illness inhabits one person but its consequences touch a family and a community.

This is where any serious consideration of health resilience should begin.

Health resilience is not one program within transformation; it is part of transformation’s capacity to serve human life

Dr. Ghazi Faisal Binzagr

The term is commonly associated with the ability of health systems, including hospitals, to withstand emergencies: pandemics, natural disasters, supply shortages or sudden pressure on medical capacity. These capabilities are indispensable. COVID-19 demonstrated, however, that a health emergency does not remain within healthcare. It also moves through families and schools, work and travel, economies and supply chains, and ultimately into the heart of national decision-making and security.

Yet a health system may remain operational while the health of society deteriorates.

Health resilience must therefore mean more than keeping institutions functioning through crisis. It must encompass the ability of a society to cultivate health before illness, respond intelligently when illness arrives and preserve dignity and meaning when medicine cannot restore the body to what it once was.

Such resilience is not created by strong institutions standing apart. It grows when their knowledge and capabilities remain connected — to one another and to the human being they ultimately serve.

Not far from the cancer center, at the University of Shizuoka, I encountered two practical examples of how such connections are cultivated.

Japan and Singapore are very different yet each has cultivated something approaching a national miracle

Dr. Ghazi Faisal Binzagr

Students of pharmaceutical sciences were being trained in the administration of medicines, including injections, although many would never perform such procedures professionally. The purpose was not to blur professional boundaries but to prevent pharmaceutical knowledge from becoming detached from human experience. A medicine is not only a compound to be formulated, tested or dispensed. It eventually enters a living body, carried by trust and accompanied by consequence.

Nearby, the university’s botanical garden, used in pharmaceutical, nutritional and food studies, extended the same principle in another direction. If the training connected medicine to the person who receives it, the garden connected modern science to the living world from which much medical knowledge first emerged. It did not ask students to choose between inherited observation and scientific rigor but to understand how one can inform the questions the other tests.

The cancer center, the pharmaceutical training and the botanical garden were not simply three interesting encounters. Together, they revealed that health resilience depends not only on the strength of individual institutions but on their capacity to remain connected: to the person who suffers, to the professional who carries responsibility, to the society in which illness occurs, and to the sources from which medicine continues to learn.

Saudi Arabia’s transformation gives this understanding immediate relevance. Vision 2030 has widened the connections through which the Kingdom understands progress, while COVID-19 revealed how inseparable health is from the economy, education, mobility and national security. Health resilience is not one program within transformation; it is part of transformation’s capacity to serve human life.

The burden of chronic disease makes this urgent. Diabetes affected an estimated 5.3 million Saudi adults in 2024, with an age-standardized prevalence of 23.1 percent. At such scale, illness cannot be treated as a succession of isolated clinical episodes. It is a continuous human reality and care must learn to become continuous with it.

Behind those numbers, in Saudi Arabia today is a person who can sleep while their glucose levels continue to be monitored. As family members rest nearby, readings can reach health institutions, helping reveal change, anticipate risk and guide care. Technology does not replace the concern of those beside that person; it allows the health system to join them in caring, extending institutional capability into the home without displacing the relationships that make it a place of belonging.

But continuity cannot begin only after diagnosis.

Through my years with the Saudi Sports for All Federation, I have witnessed how accessible movement, rooted in families, neighborhoods and communities, can turn health from something medicine repairs into something society creates. Health transformation, Sports for All and the Kingdom’s quality of life ambitions shape the same human life from different directions.

The encounters in Shizuoka formed part of a larger Japanese lesson. Japan’s longevity is a civilizational achievement but it is also requiring the country to reconsider care, independence, community and purpose. Its value lies in the knowledge it continues to accumulate: how to support older people within their communities, connect medical and long-term care, use technology to strengthen human presence rather than replace it, and ensure that years added to life remain years of contribution and belonging.

Japan’s use of robotics offers a striking example. Wearable systems can assist movement, surgical robots can extend the physician’s precision and robotic avatars can enable people confined by illness or disability to participate from afar. The machine matters but the deeper achievement is human: preserving agency and belonging when physical strength changes form.

Saudi Arabia is shaping new systems while its population remains comparatively young; Japan is adapting established systems as longevity transforms society. Their differences make them valuable to one another. The opportunity is not simply to transfer solutions but to discover how health systems can remain technically advanced, socially connected and fully human.

My years in Japan have reminded me of another country I have visited and studied repeatedly for more than a decade. Singapore’s achievement lies not in one health program but in its practice of national transformation: balancing access, quality and affordability while connecting health to housing, mobility, economic sustainability and quality of life.

What has impressed me most is the movement between scale and detail. National objectives provide direction; close observation reveals where policy must be refined. Concepts are tested against daily life and reconsidered whenever progress in one field creates consequences in another.

Japan and Singapore are very different yet each has cultivated something approaching a national miracle — not perfection but a distinctive capacity built from history, necessity and human effort. Saudi Arabia brings its own: the energy of a society transforming at exceptional speed, technological ambition joined to enduring family bonds, and a vision placing quality of life within national progress.

The invitation is larger than an exchange of best practices. It is for societies to bring their finest qualities into a deeper relationship. No country contains the complete wisdom the future requires. Through the quality of their connections, nations may create possibilities that none could produce alone.

These reflections return me to where they began: the Shizuoka Cancer Center and to the unsettling lesson cancer itself offers about change. Life depends upon change: cells divide, organisms adapt and societies renew themselves. Yet not every change serves life. Growth detached from the order that sustains the whole can become destructive.

The analogy must not be pushed too far. But it raises a question at the heart of every national transformation: How can change strengthen the whole rather than advance one part at the expense of others?

Speed is not, by itself, evidence of progress, nor is the accumulation of technology or wealth. A healthy transformation holds together economic sustainability, good governance, security and a quality of life that reveals what they are ultimately for. Its measure is whether the whole has grown more capable of sustaining human life — especially when life becomes vulnerable.

For vulnerability is not a temporary defect that successful societies will eliminate. It is part of being human. We begin life dependent upon others. Many will encounter illness or disability. Those who live long enough will experience some loss of physical capacity. A society reveals its understanding of progress not only in how it celebrates strength but in how it accompanies people when strength changes form.

Arabic and Islamic tradition offers a name for the wisdom such a society requires. The physician was often called “al-hakim,” the wise one. The word implied more than command of remedies. It joined knowledge with judgment, the body with the person and the act of treatment with responsibility for the balance of life.

Perhaps the future asks us to enlarge this meaning beyond the individual physician. The wisdom of al-hakim may become a collective quality: science exact enough to determine what can be done; judgment broad enough to ask what should be done; and societies humble enough to place their finest knowledge in one another’s service.

For we are embodied beings but we are not bodies alone. We are memory and relationship, aspiration and responsibility, matter and spirit. Medicine can preserve life and relieve suffering. Society must help ensure that the life preserved can still find belonging, dignity and meaning.

The future of health will not be decided only by what medicine becomes. It will also be decided by what society remembers a human being to be.

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Ebola spreads to seventh DRC province as gov’t insists cases are declining | Ebola

Ebola has reached a seventh province in the Democratic Republic of Congo after an infected man travelled across the country and through Rwanda and Uganda. Virologist Placide Mbala said the government is seeing signs of declining transmission but remains cautious about the outbreak.

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DR Congo’s worst Ebola epidemic ever passes 7,000 cases | Ebola News

DRC detected the outbreak of the rare Bundibugyo virus in mid-May; nearly 3,400 people have since died.

More than 7,000 Ebola cases have been recorded in the Democratic Republic of the Congo’s (DRC) worst outbreak of the deadly disease, according to figures from Congolese authorities.

The DRC officially detected the latest outbreak in mid-May, but experts suspect it had been spreading under the radar for weeks before.

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Of the 7,022 registered cases, 3,398 people have died, according to DRC authorities. Currently, 837 people are in isolation or receiving treatment.

The outbreak of the rare Bundibugyo virus, DRC’s 17th Ebola epidemic, began in the northeastern Ituri province.

It has since spread across conflict-plagued, remote eastern and northern regions where armed groups have roamed for decades, the presence of the state is weak and health infrastructure is largely lacking.

Earlier this week, one case of the disease was confirmed in a seventh province, South-Ubangi, which is in the northwest of the country bordering the Central African Republic and Congo-Brazzaville.

Most of the recorded cases remain in Ituri, where Ebola has been detected in schools in the days after the post-summer holiday return to classes, causing alarm among parents and health workers.

“We are very worried because we don’t know which child comes from which family or what the health status of the members of that family is,” Angele Magani, a mother of a schoolboy in Bunia, Ituri’s provincial capital, told the AFP news agency.

“We are so scared, even though the school authorities reassure us about the health measures that have been put in place,” she added.

Bunia school official Roger Mungimbo told AFP that “there is a mandatory hand-washing system with soap, and we have also done everything possible to have a maximum of 30 pupils per classroom”.

“We regularly make the children aware that they must not touch each other, must not greet each other and must wash their hands regularly,” he added.

Ebola, which has killed more than 15,000 people in Africa over the last 50 years, is transmitted through contact with bodily fluids and can cause severe internal and external bleeding and organ failure.

The world’s deadliest outbreak in West Africa in 2014-2016 was the Zaire Ebola virus. That epidemic killed more than 11,325 people, mainly in Guinea, Liberia and Sierra Leone.

The Bundibugyo strain currently seen in DRC has no approved vaccine or treatment currently, although several potential treatments and vaccines are being tested.

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Dr Amir Khan says ‘no’ and explains common method for treating nosebleeds is wrong

NHS GP Dr Amir Khan says a common method for dealing with nosebleeds is not correct

Dr Amir Khan has offered guidance on how to properly treat a nosebleed, revealing that many people have been receiving incorrect advice. The well-known TV doctor and NHS GP, recognised for his regular slots on ITV’s This Morning and Lorraine, discussed the matter with his followers on the latest instalment of his podcast, No Appointment Necessary.

His explanation may come as a surprise to some who have been instructed to do something entirely different when dealing with a nosebleed. Co-host Cherry Healey appeared to be among them, as she questioned him about the advice people have given her for managing a nosebleed.

She said: “You know when someone gets a nosebleed, they always get told to put their head back. It’s so awful when you get a nosebleed and someone tells you that because it’s what you don’t want to do. Is that true?”

The doctor responded: “No. It used to be that, but it’s not head back. It’s head forward. Yeah, because if you go back, you could swallow the blood and then cause all sorts of issues.”

He then outlined what you should do instead, saying: “First of all, you want to pinch the soft bit of your nose just underneath the bone. I’m talking like this now because I’m doing it. So pinch that bit as tight, as tight as you can and then lean forward.

“So head between your knees or lean as far forward as you can for, you’ve guessed it, 15 minutes. 15 to 20 minutes is when anything is bleeding.

“That’s how long you need to put pressure on it.” Cherry then replied: “Because that’s how long it takes to clot.”

His advice is important because many people have been given incorrect advice. McGill University in Canada says the tilt-the-head-back method is a ‘common misconception’.

Its website states: “First aid standards have changed throughout the years, making it difficult to keep up with the right practice. Tilting your head backwards is common misconception. Currently, Red Cross standards and most clinicians inform us to sit neutral, tilt head slightly forward, pinch the bridge of the nose, and wait for 10-15 minutes.”

NHS advice on what to do if you have a nosebleed

The NHS website advises that if you experience a nosebleed, you should sit down and lean forward, with your head tilted forward and your mouth open; pinch your nose just above your nostrils for 10 to 15 minutes; and breathe through your mouth. It adds: “Holding an icepack (or a bag of frozen peas wrapped in a tea towel) on the top of the nose may help reduce the blood flow. But the evidence to show it works is not very strong.”

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It also provides guidance on what to do for the 24 hours following a nosebleed. To reduce the likelihood of another nosebleed, for 24 hours afterwards, it recommends you should try not to pick your nose, blow it, or pick any scabs.

It also suggests avoiding lying down flat, doing any heavy lifting or strenuous exercise, or consuming hot drinks or alcohol.

Dr Amir Khan tells patients what not to say in his practice

The doctor’s guidance comes a day after he shared with Instagram followers a list of things he does not want to hear from his patients. The reassuring post, which we reported about on Friday, stated people should not apologise for their weight, their toenails, or their hairy legs.

He said: “Please, you’re having a medical examination, I am not bothered about anything else. “He also said people should not apologise if they feel the need to cry, or if they cannot remember the name of their tablets. And he said: “Please don’t say things like I’m sorry to waste your time.

“If something is worrying you enough that you’ve come to make an appointment to come and see me, that’s what I’m here for.” He concluded by noting: “The only thing that I care about is that you feel able to tell me what’s really going on.

“Because the thing you might be embarrassed about might actually be really important, and I can’t help something you feel ashamed to tell me. So, come as you are, cry if you need to, don’t shave anything on my account, and please stop apologising for just being a patient. You’re not an inconvenience, you’re literally the reason why I’m here.”

Find episodes of the podcast on YouTube, Apple or other platforms.

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AICAR and Its Scientific Potential in Metabolic Signaling Research

Within the increasingly specialized field of peptide and metabolic signaling inquiry, AICAR has emerged as a particularly intriguing molecular subject due to its theorized relationship with cellular energy regulation, mitochondrial communication pathways, and adaptive biochemical signaling environments. Although often associated with metabolic research discussions, AICAR occupies a broader scientific position believed to extend beyond simple energy-oriented investigation. Research literature increasingly suggests that the compound may participate in highly nuanced intracellular processes connected to stress adaptation, nutrient sensing, enzymatic communication, and molecular resilience mechanisms across diverse research models.

AICAR, formally known as 5-Aminoimidazole-4-carboxamide ribonucleotide, is structurally related to naturally occurring intermediates involved in purine biosynthesis. Because of this relationship, the molecule has attracted considerable attention in biochemical research environments focused on cellular metabolism and signaling coordination. Investigations purport that AICAR may function as an indirect activator of AMP-activated protein kinase, commonly abbreviated as AMPK, a regulatory enzyme frequently theorized to operate as a cellular energy sensor within the system.

AMPK itself has become a major point of interest in contemporary molecular science because of its proposed involvement in maintaining energetic equilibrium under fluctuating environmental conditions. Research indicates that when energetic stress signals accumulate within cellular systems, AMPK-associated pathways might influence a wide range of downstream biochemical activities involving glucose handling, lipid signaling, mitochondrial turnover, and protein synthesis coordination. Due to AICAR’s theorized interaction with this signaling network, the compound has become deeply integrated into experimental metabolic frameworks.

One of the most discussed properties of AICAR involves its potential relationship with mitochondrial biology. Mitochondria, frequently characterized as central energetic regulators within cellular systems, remain heavily studied due to their possible participation in longevity-associated signaling, oxidative balance, and adaptive cellular responses. Scientific literature suggests that AICAR exposure in controlled research settings may correlate with shifts in mitochondrial biogenesis signaling pathways. It has been hypothesized that this relationship might involve transcriptional regulators such as PGC-1α, a coactivator frequently examined in mitochondrial adaptation research.

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Because mitochondrial functionality intersects with numerous branches of biochemical inquiry, AICAR has gradually entered investigative discussions involving endurance-associated metabolic adaptation, cellular resilience environments, and nutrient-sensing systems. Researchers have theorized that the peptide-related compound may provide insight into how cells adapt under resource-limited conditions, particularly in environments characterized by altered energetic availability.

Another area of increasing scientific curiosity involves the potential relationship between AICAR and glucose metabolism pathways. Research indicates that AMPK-associated signaling networks may influence glucose transporter activity and intracellular glucose utilization mechanisms. Within these frameworks, AICAR has been explored as a molecular research tool with the potential of assisting investigators in mapping the biochemical hierarchy involved in carbohydrate-associated signaling environments.

Importantly, these investigations do not merely focus on isolated metabolic reactions. Instead, contemporary scientific inquiry increasingly examines metabolic signaling as part of a larger communication network connecting cellular stress responses, inflammatory mediators, redox balance systems, and transcriptional regulation mechanisms. Within this broader perspective, AICAR may represent more than a singular metabolic modulator. It might instead serve as a biochemical bridge connecting energetic signaling to adaptive cellular communication networks.

Research literature has also explored the possibility that AICAR-associated pathways may intersect with autophagy-related signaling. Autophagy, a tightly regulated intracellular recycling mechanism, remains a prominent topic within longevity-oriented and degenerative-condition research domains. Investigations suggest that AMPK-associated activation environments might influence autophagic coordination through interactions with mTOR-related signaling pathways. Because AICAR appears connected to AMPK-associated activity, scientists have theorized that the molecule may help researchers better understand the balance between anabolic and catabolic cellular states.

The relationship between AICAR and mTOR signaling has generated considerable attention in molecular biology discussions. mTOR, or mechanistic target of rapamycin, is widely recognized as a nutrient-responsive regulatory complex associated with growth-related cellular processes. Research models suggest that energetic stress signaling may suppress certain mTOR-associated activities while promoting cellular conservation mechanisms. Within this context, AICAR has become increasingly valuable as an investigative compound for studying how systems prioritize energetic resources during fluctuating environmental conditions.

Beyond metabolism-centered inquiry, AICAR has also entered conversations surrounding cardiovascular signaling research. Investigations purport that AMPK-associated pathways may participate in vascular regulation, endothelial communication, and oxidative stress adaptation. Some researchers hypothesize that AICAR-related signaling environments could assist in clarifying how cellular systems respond to energetic strain within circulatory tissues. Although many mechanistic questions remain unresolved, the peptide-associated molecule continues to attract interest in biochemical discussions involving cellular oxygen utilization and stress-response coordination.

Neurological research domains have likewise shown growing interest in AMPK-associated signaling pathways. Cellular energy regulation within neurological tissue remains a major focus of contemporary investigation due to the substantial energetic demands associated with neural communication. Scientific discussions increasingly propose that metabolic imbalance, mitochondrial dysfunction, and impaired energetic adaptation might intersect with neurodegenerative signaling environments. Within these frameworks, AICAR has occasionally been examined as a research compound with the potential of illuminating relationships between energetic sensing pathways and neuronal maintenance mechanisms.

Another compelling dimension of AICAR research involves inflammatory signaling environments. Chronic inflammatory activity has become increasingly recognized as a contributing factor across multiple degenerative conditions and longevity-associated biological shifts. Research indicates that AMPK-associated pathways may interact with inflammatory mediators and oxidative stress regulators. Consequently, AICAR has entered exploratory discussions focused on how energetic signaling networks may influence broader cellular communication systems tied to inflammation-associated processes.

Interest in oxidative stress biology has further expanded AICAR’s research relevance. Oxidative balance remains essential for maintaining stable intracellular environments, particularly under metabolically demanding conditions. Some investigations suggest that AMPK-associated signaling might influence antioxidant regulatory pathways and mitochondrial stress adaptation responses. Within these experimental contexts, AICAR has been hypothesized to serve as a useful molecular tool for studying how cells attempt to preserve equilibrium when exposed to fluctuating energetic or oxidative conditions.

Although many mechanistic uncertainties remain unresolved, AICAR persists as a compelling molecular subject whose properties may contribute to a deeper understanding of how energetic regulation influences cellular coordination across complex biological systems. In modern scientific inquiry, where interconnected signaling pathways increasingly define research priorities, compounds such as AICAR may remain valuable tools for exploring the sophisticated architecture underlying metabolic adaptation and cellular communication throughout the system. Researchers interested in more useful peptide data are encouraged to visit www.corepeptides.com.

References

[i] Hardie, D. G. (2011). AMP-activated protein kinase: An energy sensor that regulates all aspects of cell function. Genes & Development, 25(18), 1895–1908. https://doi.org/10.1101/gad.17420111

[ii] Steinberg, G. R., & Kemp, B. E. (2009). AMPK in health and disease. Physiological Reviews, 89(3), 1025–1078. https://doi.org/10.1152/physrev.00011.2008

[iii] Corton, J. M., Gillespie, J. G., Hawley, S. A., & Hardie, D. G. (1995). 5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? European Journal of Biochemistry, 229(2), 558–565. https://doi.org/10.1111/j.1432-1033.1995.tb20498.x

[iv] Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y. X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H., Kang, H., Shaw, R. J., & Evans, R. M. (2008). AMPK and PPARδ agonists are exercise mimetics. Cell, 134(3), 405–415. https://doi.org/10.1016/j.cell.2008.06.051

[v] Jäger, S., Handschin, C., St-Pierre, J., & Spiegelman, B. M. (2007). AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α. Proceedings of the National Academy of Sciences, 104(29), 12017–12022. https://doi.org/10.1073/pnas.0705070104

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Katie Price shares worrying health update about her sick mum amid terminal illness battle

FORMER glamour model Katie Price has shared a worrying health update about her mum, Amy, amid her terminal illness battle.

Amy Price was diagnosed with a terminal lung disease called Idiopathic Pulmonary Fibrosis (IPF) back in 2017 with the irreversible scarring of the lungs making it difficult for her to breathe.

Amy Price Katie Price posed up together at the screening of her Sky documentary Credit: PA
Amy Price has been in and out of hospital amid her ongoing battle with a terminal disease Credit: Instagram

During a Good Morning Britain interview in May, Katie, 48, told how her mum was “really not well.”

The admission came two months after Amy was hospitalised in March after being diagnosed with an infection.

Amy has been in and out of hospital, battling the cruel disease for years.

Now, Katie has shared a health update on her mum and it doesn’t sound positive as she’s made a return to the hospital.

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Speaking on her podcast The Katie Price Show, she said: “Mum is still in hospital. She’s very poorly.

“She’s very poorly at the minute, but she loves watching what we’re doing. She loves us at the NTAs, she loved it, seeing us all there.”

Amy appeared fit and fighting at the launch of her new documentary Katie Price: Nothing To Hide.

The glamorous 74-year-old made sure she was right by her daughter’s side for her big night.

Katie told how her mum enjoyed seeing her, Princess and Junior Andre on TV at the NTAs Credit: Getty
Katie and her sister Sophie believed her mum was going to die while filming her documentary Credit: Instagram

She wore a beautiful white and blue floral dress and was seen posing up for snaps with a beaming Katie.

During a podcast episode with her sister, Sophie, back in July Katie revealed she was terrified her mum was going to die while they were filming her Sky show.

“There were so many times we thought we were gonna lose mum through the filming,” admitted Katie.

Sophie agreed saying at one point, she didn’t think Amy was “going to make it.”

Katie went on: “She just keeps battling through and I never thought she’d make the BAFTAs [in February], none of us did.”

In 2023, Amy underwent a major lifesaving lung transplant after being in critical condition in a coma.

Despite the transplant, Amy’s health has remained touch-and-go with Katie noting her struggles with mobility and breathlessness.

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Arab News | Overmars resigns as Royal Antwerp sports director due to health issues

ANTWERP, Belgium: Soccer great Marc Overmars is stepping down as Royal Antwerp’s sports director due to health issues.

Overmars, who joined the Belgian club in 2022, explained his decision in a letter to supporters published on Wednesday as he mentioned “all the fatigue that has built up over the years and the enormous amount of stress.”

The former Netherlands, Arsenal, Barcelona and Ajax winger recovered from a mild stroke in December 2022.

“You all know that my health has not been optimal,” he wrote. “But now I feel very clearly that I can no longer cope with this hectic, stressful professional life.”

Overmars previously spent nearly a decade as director of football at Ajax, the Dutch club where he began his playing career but resigned after he was found to have sent inappropriate messages to several female colleagues. He apologized for his behavior.

“My energy is now completely depleted. If I do not listen to my body now, my doctors say there is a very high risk of things ending badly,” Overmars said. “So I have to make a drastic decision and completely stop my professional activities for the time being.”

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Gov. Gavin Newsom’s former chief of staff seeks to delay sentencing because of health issues

Dana Williamson, California Gov. Gavin Newsom’s onetime chief of staff, is seeking to delay her criminal sentencing date for political corruption because of health issues, according to documents filed last week in federal court.

Williamson’s attorney McGregor Scott, asked the court to delay her Sept. 17 sentencing and seal documents related to her health condition.

Scott submitted documents that reference a Sept. 4 surgery that Williamson underwent, medical records, and a text message from Williamson’s mother about the surgery.

Williamson underwent a liver transplant earlier this year, prompting a judge to delay a February hearing in her case.

A spokesperson for the U.S. attorney’s office for the Eastern District of California didn’t immediately respond to a request for comment about the requested sentencing delay.

Scott declined to comment.

Williamson, who worked for Newsom until 2024, pleaded guilty in May to three counts, including committing bank and wire fraud.

Williamson, a veteran political consultant who also formerly worked for former Govs. Jerry Brown and Gray Davis, admitted she took part in a scheme from 2022 to 2024 to skim campaign funds from then-U.S. Health and Human Services Secretary Xavier Becerra, now a leading candidate for governor, and divert the money to Becerra’s then-chief of staff.

She also admitted in her plea deal to filing a false tax form in 2024 and lying to FBI agents that same year.

Beyond lying to the FBI about the scheme involving Becerra, Williamson misled federal authorities on another topic, the plea agreement stated.

She lied to FBI agents when asked about the state’s lawsuit against video game company Activision Blizzard Inc., details contained in the November indictment against Williamson and other public records show.

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Napoli’s Scott McTominay undergoes successful heart surgery | Football

The midfielder, who will return to training in two weeks, will miss Wednesday’s Champions League game against Arsenal.

Scotland midfielder Scott McTominay has had successful surgery on a minor heart issue on Tuesday and will return to training in two weeks’ time, his club Napoli said.

The former Manchester United player recently experienced a heart rhythm disorder, something which is not considered serious but did require surgery.

“On Tuesday morning, Scott McTominay underwent an ablation procedure at Spire Manchester Hospital. The operation was a complete success,” the Serie A club said in a statement.

“McTominay will rest for two weeks and then resume training.”

McTominay, 29, has been a key player for Napoli since joining from Manchester United in 2024, scoring 27 goals in 82 matches.

But he was off-form in their opening two Serie A games.

Napoli previously said McTominay would miss Scotland’s upcoming Nations League fixtures against Slovenia (twice), Switzerland and North Macedonia.

Napoli, who have just three points from their opening three Serie A games this season, host Arsenal in the Champions League on Wednesday and then play Bologna and Fiorentina before the international break.

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Arab News | Parents of San Diego mosque gunman say a mental health facility failed to heed FBI warning

LOS ANGELES: Just days before two teenagers carried out a mass shooting at a San Diego mosque, federal law enforcement officials warned the parents of one of the shooters that their son was making concerning comments about school shootings on the dark web, according to new details included in a recently filed lawsuit.

The mother of Caleb Vazquez alleges in her lawsuit that Park Mental Health Treatment of San Diego failed to intervene despite signs that her 18-year-old son posed an imminent threat to himself and others. Vazquez was living there and receiving treatment for a range of mental health conditions, including depression and psychotic episodes, the lawsuit says. The court filings follow a number of high-profile convictions of guardians who provided teenagers with weapons that were later used in mass shootings.

The FBI called Vazquez’s mother on the evening of May 14, and she said she immediately left a message with the treatment facility to notify its staff, according to the lawsuit, filed in a San Diego court on Aug. 31. Vazquez’s mother again shared the FBI’s warnings with her son’s therapist on May 15 and with a program director later that night.

On May 18, the morning of the shooting, employees at the facility contacted Vazquez’s mother to tell her that he was missing. Video surveillance footage subsequently showed Vazquez leaving the property at 8 p.m. the night before.

Vazquez’s parents were driving around looking for him on the morning of the shooting. Vazquez and another teenager killed three people at the San Diego mosque that day before taking their own lives.

It is unclear whether Vazquez was allowed to leave the previous evening or whether he broke facility rules by doing so. Park Mental Health offers a range of treatment options, some of which advertise 24-hour surveillance, while others provide more limited counseling.

The center did not immediately respond to an emailed request for comment Saturday afternoon. In a previous statement to radio station KPBS, Park Mental Health disputed the assertions in the lawsuit.

“While it is understandable that his parents might seek to blame someone in their time of loss, this lawsuit is misguided in that neither Park nor its employees are responsible for Mr. Vazquez’s actions,” the statement to KPBS read. “Only he and his coconspirator bear responsibility for their conduct and, ultimately, his death.”

An FBI spokesperson declined to comment Saturday, citing agency policy.

The FBI’s alleged contact with Vazquez’s parents was not the first sign of his mental deterioration.

Vazquez had been hospitalized for roughly three days in January 2026 after telling a classmate that he wanted to carry out a school shooting.

Almost exactly a year earlier, Vazquez was flagged to law enforcement for exhibiting alarming behavior and idolizing Nazis, prompting police to confiscate 26 guns from his father under a 2014 California law allowing firearms to be taken from people considered dangerous.

Authorities have said Vazquez met the other shooter, Cain Clark, 17, online and that both were radicalized there. Police have not shared more details about how they knew each other or specified whose weapons were used in the shooting.

The lawsuit was filed on the same day that North Carolina authorities announced the indictment of a 17-year-old in connection with the shooting.



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