News of Eric Dane’s death Thursday was met with an outpouring of grief by celebrities, who expressed their admiration for the TV star’s mischievous on-screen charisma and his advocacy efforts during his battle against ALS.
Dane is best known for his role as Dr. Mark Sloan, or “McSteamy,” on “Grey’s Anatomy” and recently portrayed the dark and secretive father Cal Jacobs in HBO’s “Euphoria.” He died at age 53, less than a year after publicly announcing his diagnosis with the neurodegenerative disease.
Alyssa Milano, who was Dane’s romantic co-star on “Charmed,” shared a heartfelt message on Instagram praising his cheeky, yet tender spirit and deep love for his daughters.
“I can’t stop seeing that spark in Eric’s eye right before he’d say something that would either make you spit out your drink or rethink your entire perspective,” said Milano. “He had a razor-sharp sense of humor. He loved the absurdity of things.”
HBO Max shared a statement on Instagram, lauding Dane’s talent and saying the network was “fortunate to have worked with him on three seasons of Euphoria.” The show’s creator, Sam Levinson, shared a statement with Variety saying he’s heartbroken by the loss of a dear friend.
“Working with him was an honor,” Levinson said. “Being his friend was a gift. Eric’s family is in our prayers. May his memory be for a blessing.”
Former “Grey’s Anatomy” showrunner Krista Vernoff shared an Instagram post fondly reminiscing about when Dane returned to the set in 2021 to film a dream sequence featuring his character, who died in Season 9. Although it was shot during the pandemic, he “broke the rules” and gave her a huge hug.
“The thing I will remember most about Eric Dane are his hugs,” Vernoff wrote. “The best hugs. Oh my friend. I wish you peace.”
Dane was preparing to publish his memoir, “Book of Days: A Memoir in Moments,” later this year with Maria Shriver’s publishing imprint, the Open Field.
Shriver said Dane was heroic in the way he handled his disease and used his platform to raise awareness about ALS.
“He told me he wanted his family to know how much he loved them, and he wanted to leave them a story they could be proud of,” she said in a statement on X. “My love goes out to his family, and to all those battling this cruel disease, as well as all those caring for someone battling it.”
In 2025, Dane drew on his personal experiences with the condition to portray a firefighter living with ALS on “Brilliant Minds” and advocated for legislation to provide funding for ALS research and give patients early access to treatments.
He worked closely with the nonprofit organization I Am ALS to raise money to research new treatments for the disease, which currently has no cure.
“Eric brought humility, humor, and visibility to ALS and reminded the world that progress is possible when we refuse to remain silent,” the organization said in a statement. “Eric was more than a supporter of our mission — he was part of our family.”
ALS, also known as Lou Gehrig’s disease, is a progressive disease that damages nerve cells controlling voluntary muscles, typically causing death two to five years after diagnosis.
Nina Dobrev, Dane’s co-star in the western romance movie “Redeeming Love,” wrote on her Instagram story that she was heartbroken by his death.
“He was warm, generous, prepared, and so passionate about what he did,” she said. “He led with kindness and made everyone on our set feel seen.”
Times staff writer Alexandra Del Rosario contributed to this report