vaccines

The mass-produced COVID-19 vaccines built using the mRNA model – which were rapidly manufactured during the global pandemic – could also help the immune system recognise and attack cancer tumours, new studies have shown.

Studies in mice and an analysis of medical records of cancer patients – who received mRNA shots for COVID-19 before starting immunotherapy for cancer treatment – revealed a startling pattern: the vaccinated patients lived significantly longer than those who had not received the shots.

A team of researchers from the University of Florida and the University of Texas MD Anderson Cancer Center presented the results this week at the European Society for Medical Oncology Congress in Berlin and published in the peer-reviewed journal, Nature.

The results, they say, reveal that the mRNA vaccines do not just prevent infection – they also “wake up” and prompt the body’s immune system to fight tumours.

The discovery has come at a time when US President Donald Trump’s administration has slashed funding for mRNA research.

So, why is this being touted as groundbreaking? What does it mean for cancer patients? And how did the COVID-19 pandemic become the medium for this unlikely discovery?

What is an mRNA vaccine?

Unlike traditional vaccines, which used weakened or inactive parts of a virus to trigger the immune system to build a defence, mRNA vaccines deliver a small strand of genetic code known as “messenger RNA” directly into the body’s cells.

The cell reads this blueprint as an instruction to manufacture a spike protein which mimics that of the virus, and display it on its surface, effectively waving a red flag that alerts the immune system to build a defence.

The body then creates antibodies and memory cells trained to recognise and attack that protein spike if it ever appears again.

How did researchers discover the link between mRNA and cancer?

This is an area of research which has been going on for some years, most notably by paediatric oncologist Elias Sayour, the Stop Children’s Cancer/Bonnie R Freeman Professor for Pediatric Oncology Research at the University of Florida, in the United States.

The COVID-19 pandemic presented a particular opportunity to study the implications of mRNA for cancer treatment as the world moved en masse to vaccinate the population.

When Sayour’s former student, oncologist Adam Grippin, examined clinical data of more than 1,000 patients treated between August 2019 and August 2023 at the MD Anderson Cancer Center, he found a striking pattern.

People who had received a COVID-19 mRNA vaccine within 100 days of starting immunotherapy lived significantly longer than those who received the same medical treatment but did not have the vaccine.

How much longer did people live with the vaccine?

For patients with advanced lung cancer, the median survival rate nearly doubled if they had the vaccine, rising from 20.6 months to 37.3.

More strikingly, the survival improvements were most pronounced in patients with immunologically “cold” tumours – meaning that the mRNA vaccine appeared to “wake up” the immune system in patients with these harder-to-treat cancers – turning “cold” tumours into ones the immune system could more easily recognise and attack.

The researchers noted that their findings were consistent across varying factors, such as different vaccine manufacturers, doses and time of vaccination.

The researchers also compared the survival rates in a smaller group of patients receiving immunotherapy for metastatic melanoma, the most advanced stage of a type of skin cancer. In the study, 43 patients had an mRNA COVID vaccine and 167 did not.

Patients who did not receive the vaccine had a median survival of just more than two years. By contrast, those who were vaccinated before starting treatment had not yet reached their median survival point more than three years into follow-up, the research found.

How does it work?

The researchers discovered that mRNA vaccines work like an alarm for the body’s defence system.

When the vaccine is given, it puts the immune system on alert, making it more likely to notice cancer cells that it might have ignored before. Once the immune system is activated, it begins to attack these cells.

But cancer cells fight back. They produce a protein called PD-L1, which works as a shield that “hides” them from the immune system. However, there are drugs known as immune checkpoint inhibitors that can block this shield.

When both the vaccine and these drugs are used, it creates the ideal situation – the immune system is active and alert, and the cancer’s defences are down, Grippin explained.

While the researchers said that they do not yet fully understand the mechanisms, the findings suggest that mRNA vaccines can be used to re-programme immune responses to cancer.

What does this mean for cancer patients?

These findings are preliminary. If, however, the study is validated in clinical trials, it could have huge implications for the treatment of cancer.

“These vaccines produce powerful anti-tumour immune responses that are associated with massive improvements in survival for patients with cancer,” Grippin said.

“The implications are extraordinary – this could revolutionise the entire field of oncologic care,” said Sayour. “We could design an even better nonspecific vaccine to mobilise and reset the immune response, in a way that could essentially be a universal, off-the-shelf cancer vaccine for all cancer patients.”

Grippen, who co-led the study with Steven Lin, professor of radiation oncology, said his team is launching a Phase 3 clinical trial to confirm the initial results and investigate whether COVID mRNA vaccines should be made part of the standard of care for patients.

What did scientists find in tests with mice?

In the mouse experiments, researchers found that injecting an mRNA COVID vaccine directly into a tumour made dendritic cells – a type of white blood cell – more alert.

Once the dendritic cells picked up on presence of the tumour, they sent out signals that attracted T cells to come and attack it. In some mice, this helped slow the growth of the cancer.

But there’s a big catch. Not everyone naturally has T cells that are capable of killing cancer cells. For some people, their immune system can tell that a tumour is dangerous, but their specific T cells do not know how to destroy it.

That’s one reason why immunotherapies – treatments that boost the immune system to fight cancer – work for some patients but not for others.

Having an mRNA COVID vaccine will not make your body produce new tumour-fighting T cells. What it might do, based on this early research, is make dendritic cells more likely to notice a tumour and effectively deploy the T cells.

Health officials in the United States are reviewing whether to remove aluminium from some common vaccines, as part of the Trump administration’s escalating attacks on vaccines.

The Department of Health and Human Services has reduced some vaccine access. The agency scaled back COVID-19 vaccine recommendations, approved COVID-19 vaccines for fewer people and aimed to remove the preservative thimerosal from US vaccines. Experts told PolitiFact scientific research did not support its removal.

During a September 22 news conference, in which US President Donald Trump told people not to take Tylenol during pregnancy, he also mentioned another objective. “We want no aluminium in the vaccine,” he said. The administration was already in the process of removing aluminium from vaccines, he added.

About two weeks later, on October 8, the US Centers for Disease Control and Prevention’s (CDC) Advisory Committee on Immunization Practices, or ACIP, announced a new working group focused on the childhood vaccine schedule. Its discussion topics include vaccine ingredient safety and aluminium adjuvants.

Robert Malone, an ACIP member who has opposed COVID-19 vaccines, told Axios he expected the ACIP would determine there was “a lot of evidence” of “issues” with aluminium in vaccines. The committee would likely vote to re-categorise vaccines containing aluminium adjuvants so that people would have to discuss with their doctor before getting them, Malone told Axios.

That could have far-reaching ramifications. Here’s what to know about aluminium in vaccines.

A: Small amounts of aluminium are sometimes included in vaccines as adjuvants, or substances that boost the body’s immune response to the vaccine to ensure protection from infection.

That boost means people can get fewer vaccine doses in smaller quantities.

Q: When used, how much aluminium is in a vaccine?

A: Vaccines with aluminium adjuvants usually contain less than 1mg aluminium per dose, according to the Children’s Hospital of Philadelphia.

That is a pretty abstract number. To help make it more concrete: a milligram is one-thousandth (1/1,000th) of 1g. One gram is about the weight of a raisin or a stick of gum. Imagine cutting one of those items into 1,000 equal pieces. One of the pieces would be about 1mg.

Here is another way to think about it.

People come in contact with and consume aluminium all of the time. It is one of the most abundant metal elements in the Earth’s crust, according to the US Geological Survey. It is naturally occurring in soil, air and water. Food is the main way people are exposed to aluminium. The average adult eats 7mg to 9mg of aluminium per day, according to the CDC.

A baby in its first six months might receive a total of about 4.4mg of aluminium from recommended vaccines. In the same period of time, a breastfed infant would ingest about 7mg of aluminium from breastmilk, and a formula-fed baby would ingest about 38mg from formula.

Q: How long have vaccines contained aluminium?

A: Aluminium adjuvants have been used in vaccines for more than 70 years, the CDC said.

“Aluminium is one of our oldest adjuvants; it’s been used in vaccines since the 1920s,” said Dr Peter Hotez, a Baylor College of Medicine professor and codirector of Texas Children’s Hospital Center for Vaccine Development.

Q: How do we know it’s safe to include small amounts of aluminium in vaccines?

A: Every vaccine’s safety and efficacy are tested in animal studies and human clinical trials before the US Food and Drug Administration (FDA) licenses it for public use. Every vaccine containing adjuvants has been tested, and health agencies continuously monitor their safety, the CDC said.

Over several decades of use, vaccines with aluminium adjuvants have been proven safe, the FDA said.

Vaccines containing aluminium have been “given to billions of people worldwide now”, said Dr Kawsar Talaat, a professor at Johns Hopkins Bloomberg School of Public Health.

A growing body of research has also found that aluminium adjuvants do not cause aluminium toxicity or other adverse outcomes.

Q: Do aluminium adjuvants have any risks?

A: Rarely, some people have allergic reactions to aluminium in the same way they might have allergic reactions to other substances, Talaat said.

In 2022, researchers published a retrospective, observational study on more than 325,000 children that found an association between vaccine-related aluminium exposure and persistent asthma. Association is not the same as causation, meaning the study did not prove a link between aluminium in vaccines and asthma.

Experts from the CDC and the American Academy of Pediatrics encouraged more research on the subject because the backwards-looking observational study did not prove causation and also had limitations, including that it excluded many children who developed asthma before they turned two years old.

A 2025 study found no increased risk of asthma associated with childhood exposure to aluminium-absorbed vaccines.

Q: Which vaccines contain aluminium adjuvants?

A: At least 25 vaccines approved for use in the US have aluminium adjuvants, the CDC says. That includes vaccines that protect against HPV, hepatitis A and B and diphtheria, tetanus, and acellular pertussis (whooping cough).

Q: Which vaccines do not contain aluminium adjuvants?

The CDC’s list of vaccines without adjuvants includes vaccines against COVID-19, Ebola, meningococcal, polio and rabies. Additionally, most seasonal flu shots and the vaccine against measles, mumps and rubella do not contain aluminium adjuvants.

Q: Can we remove aluminium from vaccines?

A: Not quickly. If it could be done at all, it would take years to develop, test and license new, aluminium-free vaccines. Many of the vaccines with aluminium adjuvants do not have aluminium-free formulas.

“A vaccine is licensed based on all of its ingredients and the exact manufacturing process,” Talaat said. “If you were to take an ingredient out of a vaccine, you would have to start all over with the clinical trials and the manufacturing, and it is highly possible that some of these vaccines wouldn’t work without the aluminium in there.”

Although other adjuvants exist, they are newer and often more scarce than aluminium, which is abundant.

An immediate ban on aluminium in vaccines would drastically reduce people’s ability to protect themselves and others against numerous diseases.

“I think we’d see outbreaks of vaccine-preventable diseases,” Talaat said.

Q: Why do people think aluminium in vaccines is causing autism?

A: A 2011 study said vaccines with aluminium adjuvants “may be a significant” contributing factor to the rising number of autism diagnoses in kids, Nature reported.

A year later, a World Health Organization vaccine safety committee called the 2011 study “seriously flawed”. The 2011 study and another by the same authors compared vaccines’ aluminium content and autism rates in several countries, the WHO group said, but that cannot be used to establish a causal relationship.

“We studied aluminium, and have no link between aluminium and autism,” Talaat said.

Sept. 17 (UPI) — Massachusetts says that all citizens should be vaccinated to protect against the COVID-19 virus as the Bay State will now force insurance providers to cover vaccines approved by the state.

On Wednesday, the Massachusetts Department of Public Health released its COVID-19 vaccine guidelines through 2026 that suggested all state residents get a COVID-19 shot, including children ages 6, and particularly those at higher risk of exposure, with a weakened immune system or pregnant.

“We are not going to let Donald Trump or Robert Kennedy take away your ability to make your own health care decisions,” said Gov. Maura Healey.

The decision by Massachusetts came as the Food and Drug Administration under U.S. Health and Human Services Robert F. Kennedy Jr. approved in August its most recent round of COVID shots but federally limited their use.

Healey said earlier this month that Massachusetts will begin to require health insurance companies to cover state-recommended vaccines and became the first U.S. state to do so, followed by Illinois in an executive order Friday by Gov. JB Pritzker, a Democrat.

Executive actions in Illinois and Massachusetts could be the first in a series of other similar acts by governors to create a coalition to set vaccine policy separate of federal authorities.

“Massachusetts will continue to lead with science and protect access to life-saving vaccines,” Healey, 54, said Wednesday in a statement.

Notably, the Healey administration’s plan was backed by the nonprofit entities Blue Cross Blue Shield of Massachusetts and the Massachusetts Association of Health Plans.

The newly issued state guidelines stand in stark contrast to federal recommendations by the Trump administration and Centers For Disease Control and Prevention.

Massachusetts health officials said the state acted on an “extensive review of current scientific data” consistent with widely respected groups such as the American Academy of Pediatrics.

The commonwealth’s Public Health Commissioner Robbie Goldstein reiterated Wednesday that vaccines remain the “most effective public health intervention of the past century,” adding that vaccine use has “saved millions of lives.”

Goldstein stated its guidelines were “grounded in evidence and science, driven by equity and shaped by the lived experiences” of Massachusetts’ 351 communities.

On Monday, Healey called Kennedy a “walking conspiracy theorist who is denying people vaccines and the healthcare they want and need” during a speech to Massachusetts Democrats as she hailed her administration’s new vaccine coverage mandate for insurance conglomerates.

A recent study indicated that in 2022 and 2023 more than 1.5 million “missing Americans” died due to COVID-19 in excessive deaths that could have been averted.

But on Wednesday Healey said the state was taking this action “so the people of Massachusetts know that you will continue to be able to get the vaccines you want and need — no matter what happens at the federal level.”

Also on Wednesday, ex-CDC Director Susan Minaret appeared on Capitol Hill to testify in front of lawmakers over her termination by Kennedy due to allegations that she refused to allow all decisions to be approved by political staff.