ambitious

WASHINGTON — President Trump outlined an ambitious effort Friday to develop, produce and distribute a fully-approved COVID-19 vaccine by the end of the year, a timeline that even those in charge of the project acknowledge is highly unlikely.

Trump said the $10-billion program would have a goal of producing 300 million doses to administer to Americans by January.

Officials said the initiative would seek to streamline and coordinate the work of government agencies, private industry and the military. A former pharmaceutical executive and an Army four-star general will head the effort, which the White House called Operation Warp Speed.

“We’re looking to get it by the end of the year if we can,” Trump said in the Rose Garden. “Tremendous strides are being made.”

But Trump also hedged on the importance of the effort, declaring that America is already on the rebound from the coronavirus outbreak, which has killed about 87,000 Americans and cratered the economy.

“I want to make one thing clear — vaccine or no vaccine, we’re back,” he said. He repeated a claim he’s made since the first U.S. coronavirus cases were reported three months ago, that the virus will eventually “go away” on its own.

“I don’t want people to think this is all dependent on a vaccine,” he said.

Public health officials worry about bringing a potential vaccine to market without several rounds of clinical trials to ensure that it is safe and effective.

The National Institutes of Health says one or two possible vaccine candidates could be ready for large-scale testing by July, with several others likely to follow. Elsewhere around the world, about a dozen vaccine candidates are teed up for small-scale testing or safety studies.

The tests are necessary to determine proper dosages and to avoid negative side effects. The process usually takes several years, but some of the world’s largest pharmaceutical companies are working with governments around the globe in an effort to speed up the search.

Dr. Amesh Adalja, an infectious diseases physician at Johns Hopkins Center for Health Security, said setting a deadline for a vaccine is “dangerous because you’re going to give people a false sense of hope and security.”

But he said it’s possible scientists can accelerate the usual timeline given changes in laboratory practices, including the use of “vaccine platform technologies” that allow researchers to test various candidates without developing each one from scratch, and the decision to prepare factories for mass production before officials know for certain that a particular vaccine will work.

“All of that’s going to shave time off, but everything has to go perfectly,” he said.

Dr. Jere W. McBride, an infectious diseases specialist at the Sealy Institute for Vaccine Sciences at the University of Texas, noted that no vaccine has been “developed that fast before.”

“Everything has to work and in science that’s often not the case,” he added. “Is it possible? Certainly.”

Officials involved in the new initiative echoed the president’s optimism.

Moncef Slaoui, who was chairman of vaccines at British pharmaceutical giant GlaxoSmithKline until 2017, will lead the effort. He said early clinical trials have been encouraging.

“These data make me feel even more confident that we will be able to deliver a few hundred million doses of vaccine by the end of 2020,” Slaoui said. “And we will do the best we can.”

Gen. Gustave Perna, the commanding general of the Army’s Materiel Command, will serve as chief operational officer. He called the project “a herculean task,” but expressed confidence in its success.

“Winning matters and we will deliver by the end of this year a vaccine at scale,” said Defense Secretary Mark Esper.

Part of the effort involves using the military to boost production capacity before the vaccine is ready in order to expedite distribution when one is determined safe and reliable.

Dr. Stephen Hahn, the commissioner of the Food and Drug Administration, said Tuesday at a Senate hearing that his agency would evaluate about 10 vaccine candidates in early studies, and then select three to five to progress into larger studies in humans.

Dr. Rick Bright, the ousted former head of the government agency charged with developing vaccines, has cast doubt on the administration’s rush to find a vaccine.

“My concern is if we rush too quickly, and consider cutting out critical steps, we may not have a full assessment of the safety of that vaccine,” Bright told a House committee on Thursday. “So it’s still going to take some time.”

Trump’s comments in the Rose Garden were at times drowned out by loud horns from truckers parked near the White House who were protesting reduced shipping rates. Trump dismissed the din as a “sign of love” for him.

Dr. Deborah Birx, the White House coronavirus response coordinator, and Dr. Anthony Fauci, the government’s top immunologist, stood behind Trump but did not speak. Both wore face masks, although Trump did not.

NEW YORK — Fresh off winning New York City’s mayoral election, Zohran Mamdani announced Wednesday that a team including former city and federal officials — all women — would steer his transition to City Hall, and that he would “work every day to honor the trust that I now hold.”

“I and my team will build a City Hall capable of delivering on the promises of this campaign,” the mayor-elect said at a news conference, vowing that his administration would be both compassionate and capable.

He named political strategist Elana Leopold as executive director of the transition team. She will work with United Way of New York City President Grace Bonilla; former Deputy Mayor Melanie Hartzog, who was also a city budget official; former Federal Trade Commission chair Lina Khan; and former First Deputy Mayor Maria Torres-Springer.

With his win over former Gov. Andrew Cuomo and Republican Curtis Sliwa, the 34-year-old democratic socialist will soon become the city’s first Muslim mayor, the first of South Asian heritage, the first born in Africa and the youngest mayor in more than a century.

He now faces the task of following through on his ambitious affordability agenda while navigating the bureaucratic challenges of City Hall and a hostile Trump administration.

“I’m confident in delivering these same policies that we ran on for the last year,” he said in an interview earlier Wednesday on cable news channel NY1.

More than 2 million New Yorkers cast ballots in the contest, the largest turnout in a mayoral race in more than 50 years, according to the city’s Board of Elections. With roughly 90% of the votes counted, Mamdani held an approximately 9 percentage point lead over Cuomo.

Mamdani, who was criticized throughout the campaign for his thin resume, will now have to begin staffing his incoming administration and planning how to accomplish the ambitious but polarizing agenda that drove him to victory.

Among the campaign’s promises are free child care, free city bus service, city-run grocery stores and a new Department of Community Safety that would expand on an existing city initiative that sends mental health care workers, rather than police, to handle certain emergency calls. It is unclear how Mamdani will pay for such initiatives, given Democratic Gov. Kathy Hochul’s steadfast opposition to his calls to raise taxes on wealthy people.

On Wednesday, he touted his support from Hochul and other state leaders as “endorsements of an agenda of affordability.”

His decisions around the leadership of the New York Police Department will also be closely watched. Mamdani was a fierce critic of the department in 2020, calling for “this rogue agency” to be defunded and slamming it as “racist, anti-queer & a major threat to public safety.” He has since apologized for those comments and has said he will ask the current NYPD commissioner to stay on the job.

Mamdani has already faced scrutiny from national Republicans, including President Trump, who have eagerly cast him as a threat and the face of a more radical Democratic Party that is out of step with mainstream America. Trump has repeatedly threatened to cut federal funding to the city — and even take it over — if Mamdani won.

”…AND SO IT BEGINS!” the president posted late Tuesday to his Truth Social site.

Mamdani, for his part, said at his news conference that “New Yorkers are facing twin crises in this moment: an authoritarian administration and an affordability crisis,” and that he would tackle both.

While saying he was committed to “Trump-proofing” the city — to protect poor residents against “the man who has the most power in this country,” as he explained — the mayor-elect also reiterated that he was interested in talking to the president about ”ways that we can work together to serve New Yorkers.” That could mean discussing the cost of living or the effect of cuts to the SNAP food aid program amid the federal government shutdown, Mamdani suggested.

“I will not mince my words when it comes to President Trump … and I will also always do so while leaving a door open to have that conversation,” Mamdani added.

Mamdani also said during his news conference and interviews that he had not heard from Cuomo or the city’s outgoing mayor, Eric Adams. He did speak with Republican candidate Curtis Sliwa.

A spokesperson for Cuomo, Rich Azzopardi, said he would “let their respective speeches be the measuring stick for grace and leave it at that.”

In his victory speech to supporters, Mamdani wished Cuomo the best in private life, before adding: “Let tonight be the final time I utter his name, as we turn the page on a politics that abandons the many and answers only to the few.”

Asked about the comments Wednesday on NY1, Mamdani said he was “quite disappointed in the nature of the bigotry and the racism we saw in the final weeks.” He noted the millions of dollars in attack ads that were spent against him, some of which played into Islamophobic tropes.

Izaguirre and Colvin write for the Associated Press. AP writers Jake Offenhartz and Jennifer Peltz contributed to this report.