treatment

Aug. 26 (UPI) — On Wednesday, the U.S. Food and Drug Administration announced its approval of Rasonque, a new treatment option for people with advanced pancreatic cancer.

A tablet taken once a day, the medication targets forms of a protein called RAS, which is a key driver of tumor growth in many patients with pancreatic adenocarcinoma, the most common form of the cancer, the FDA said. This form of cancer develops in cells lining the ducts of the pancreas.

“Today’s approval provides a critical new option for patients facing an extraordinarily difficult and historically hard-to-treat cancer,” said Kyle Diamantas, acting commissioner of the FDA. “It is our fundamental duty to deliver more cures and meaningful treatments to patients as quickly as possible.”

A press release from the FDA said the approval demonstrates the agency’s “commitment to moving with urgency, reducing unnecessary delays and advancing innovative treatments.”

Rasonque has been approved for adults who have metastatic pancreatic adenocarcinoma who have received at one least one prior systemic therapy or those who are not candidates for multiagent systemic therapy.

About 90% to 95% of the new cases of pancreatic cancer diagnosed in the United States each year are this form, the FDA said, citing the National Cancer Institute. Johns Hopkins Medicine also said “the vast majority” of pancreatic cancer diagnoses are this form.

In a clinical trial, the new treatment improved median overall survival to 13.2 months from 6.7 months with standard chemotherapy, the FDA said.

“This drug showed unprecedented results in an area of high unmet need,” said Angelo de Claro, director of the FDA’s Oncology Center of Excellence.

The agency granted this approval to Revolution Medicines Inc.

CORONATION Street legend Beverley Callard revealed she’s ‘quite badly burnt’ from breast cancer treatment – amid sharing a new health update.

Liz McDonald actress Beverley, 69, first revealed in February that she had been diagnosed with breast cancer.

Appearing on Irish chat show The Six O’Clock Show, the star has opened up about her current condition.

Beverley explained how the side effects of radiotherapy began to affect her after a few days.

She said: “Nausea, really tired and just wiped out a little bit.

“And I’m quite badly burnt. But I’m coping really well, actually.”

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This came after Beverley revealed she finished radiotherapy only a couple of weeks earlier.

She continued: “I got through it amazingly well. I didn’t have any time off work.

“I didn’t miss a day. So I was really sort of proud of myself for that.”

Beverley confirmed she was “back at work” and filming once again, referring to her current role as Lily Patterson on Fair City.

She concluded: “I don’t know the actual prognosis yet, I see my oncologist again in two weeks time. So I’ll know more then, but I’m doing well.”

The actress also shared how other people said to her: “You shouldn’t be working, you should be at home.”

She elaborated: “But if you are, you just sit and feel sorry for yourself.

“Believe me, I’ve done that as well, as we all do. But I need my mind to be occupied.

“If I’ve got lines to learn, it really helps. And believe me, I’ve had loads to learn, so it’s been good.”

Bev has been open with fans about the gruelling side effects as she battles cancer, and last week revealed her treatment had left her “sore and tired”.

The star told her followers: “I’ve got to speak to the hospital tomorrow.

“I’m not sure that I’m healing as well as I should be. But I’m so burnt and it’s just driving me mad.

“Also, incredibly nauseous.”

JESY Nelson has revealed the tragic reason her twin daughters’ treatment for SMA was delayed – despite the increased risk of permanent nerve and muscle damage.

The former Little Mix star details the heartbreaking moment Ocean Jade and Story Monroe, who have have Spinal Muscular Atrophy Type 1, are forced to miss out on the gene-therapy infusion earlier this year.

In her new Prime Video documentary, Jesy Nelson: Life Changing, Jesy says Story was rushed to hospital with pneumonia – just days before Ocean was struck down by another illness.

Speaking in the docu-series, which is released on Friday, July 17, Jesy said: “Not long after we got the diagnosis, they were booked in to have their treatment.

“Then Story got pneumonia and was really struggling to breathe.

“She started choking so we had to rush her into hospital. It breaks my heart because she’s so vulnerable.

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“That’s when we were told that she can’t have the treatment.”

Any delay in treatment increases the chance of permanent nerve and muscle damage

After close monitoring, it was decided that Story and Ocen were not well enough to receive the gene therapy.

Jesy added: “That was when she got given her breathing machine.

“She came home and then Ocean got ill.”

During the episode, which began filming straight after the cameras stopped rolling on her first series, Life After Little Mix.

Her partner Zion Foster – who has since split from Jesy – said: “I’m not equipped to deal with this. I’m out of my depth; emotionally, physically and mentally.”

The documentary covers their split, which was revealed by The Sun earlier this year.

Jesy has since thrown herself into work – tirelessly campaigning to raise awareness of SMA and pressure the government to add the condition onto the NHS newborn heel-prick test, which currently screens for ten other conditions.

On Wednesday, April 1, the Department of Health and Social Care announced that England will bring forward the newborn screening of SMA.

A phased rollout will begin in October 2026. However, screening will not be available in all parts of England.

There is growing anxiety among residents after nine Ebola virus patients escaped from a treatment centre in the Ituri province of the Democratic Republic of Congo (DRC) after a fire outbreak. Authorities and the local population are deeply concerned that these individuals could spread the Ebola disease to other provinces.

On June 30, nine patients suddenly vanished from the health facility after a group of hostile locals set the Nia-Nia Ebola treatment centre on fire. Among the missing patients are two confirmed cases of Ebola infection and seven suspected cases.

According to Joseph Pemanakue, the chief medical officer of the Nia-Nia treatment centre, the patients have still not been found several hours after fleeing the health facility.

“The burnt-down centre was housing two confirmed positive cases of Ebola as well as seven suspected cases. The nine patients fled from the structure and remain to be tracked down, causing fear of an increased propagation of the epidemic within the community,” Joseph said.

The attack on the treatment facility happened after some members of the community refused to surrender the body of a suspected Ebola patient to the medical team. This confrontation escalated quickly, resulting in the destruction of the treatment centre and the loss of a significant stock of medicine and medical equipment.

The local authorities consider the incident to have seriously compromised the efforts to contain the epidemic in Ituri province.

“Some opinion leaders manipulate the population by affirming that Ebola is a business, whereas the disease actually exists. In PK 51, we have recorded ten deaths. A corpse tested positive was removed from a coffin and transported by the population, an action which increases the risk of spreading the disease. The health facility responsible for taking charge of patients, which was created after several efforts, was unfortunately destroyed,” said Alexis Mungaki, a chief of the Ngayo tribal group.

The incident occurred amid heightened tensions between specific communities and the Ebola treatment teams. Health officials are concerned that the escape of confirmed and suspected patients may trigger new transmission chains, as Ituri province continues to be the focal point of the 17th Ebola outbreak in the DRC.

Sciver-Brunt first injured her calf on 29 April, suffering what was then described by England as a “minor” tear when playing in domestic cricket.

She subsequently sat out series against New Zealand and India at the start of the international summer before returning for England’s World Cup warm-up matches.

The England captain came through warm-ups against Australia and India and the first match of the World Cup against Sri Lanka but reported ‘tightness’ in a win over Ireland 10 days ago.

She has not played since and England will either play their semi-final on Tuesday or Thursday next week, depending on other results.

“The one thing you need is time,” Worth said.

“You need time to allow the muscle to repair and then strengthen in the right way. Those timelines are tight, particularly given a history of previous injuries in the same area, but not impossible.”

Calf injuries are a regular issue for cricketers. England’s leading wicket-taker James Anderson had calf problems in the latter part of his career.

Worth said this is because of issues specific to cricket, like batters having to sprint from a standing start or bowlers slamming their front foot into the crease in their delivery stride, and the make-up of the muscle.

“You have two different types of tissue that come together,” he said. “You have your calf which is the upper bit and then the Achilles tendon.

“Wherever there are two types of tissue in terms of composition, that is often where there is a weak point.

“Things like taking a run, going from 0 to 100mph, are really difficult to replicate in rehabilitation.

“You have the immediate calming down on inflammation but tendons like load and need to strengthen.

“It is very difficult to get the balance between working the muscle enough and not pushing it too far.

“Quite often calf injuries are tricky because you feel like you have done the work and you put them back onto the field in a match situation and something goes again.”

Major League Baseball says it has no concerns about Dodgers and Rams head team physician Dr. Neal ElAttrache working with players.

ElAttrache was questioned by MLB on June 12 following a detailed report by the New York Times that the renowned surgeon and sports medicine expert supported the therapeutic use of performance-enhancing drugs by UFC star Conor McGregor.

“MLB took our responsibility to conduct due diligence in this matter seriously. We interviewed Dr. Neal ElAttrache last week, covering multiple topics, and he answered our questions thoroughly,” MLB said in a statement obtained by The Times Tuesday night.

“Based on our interview, the review of relevant records, Dr. ElAttrache’s long history of support for and cooperation with the Joint Drug Program and the fact that no Therapeutic Use Exemption requests of this nature have been submitted by Dr. ElAttrache or anyone else, we do not have any concerns regarding Dr. ElAttrache’s treatment of MLB players, or his adherence to the Joint Drug Programs and related rules.

“We consider this matter closed.”

ElAttrache performed surgery on McGregor in July 2021, inserting a rod, plates and screws into his left leg after the fighter broke his tibia and fibula during a mixed martial arts bout against Dustin Poirier in Las Vegas.

McGregor’s recovery was lengthy and arduous. ElAttrache told the New York Times that while he did not prescribe steroids for McGregor, he referred him to a specialist who did. Furthermore, ElAttrache wrote a letter supporting McGregor’s request for a therapeutic use exemption from UFC drug policies.

“I felt it would be appropriate to consult other physicians with expertise in bone healing/bone metabolism,” ElAttrache told the New York Times via text. “I recommended the consultations but not the course of treatment.”

ElAttrache said he told McGregor to check with UFC drug testers about prescriptions the consultant gave him. “I purposely wasn’t involved with his evaluation by the consultant nor with prescribing medication,” ElAttrache said.

The exemption request was denied by the U.S. Anti-Doping Agency, the drug testing organization the UFC used at the time, triggering a split between the two organizations. McGregor withdrew from the UFC anti-doping program shortly thereafter and no longer was required to undergo testing for banned substances.

The report prompted MLB to talk with ElAttrache about his approach to treating players.

ElAttrache, operating primarily out of the Cedars-Sinai Kerlan-Jobe Orthopaedic Clinic in Los Angeles, has performed elbow or shoulder surgeries on prominent Dodgers past and present, including Shohei Ohtani, Clayton Kershaw, Tony Gonsolin and Walker Buehler as well as former Rams stars Cooper Kupp and Cam Akers.

Among the hundreds of surgeries performed over three decades by ElAttrache, his patients include the four 2024 MLB most valuable player and Cy Young Award winners — Ohtani, Aaron Judge, Chris Sale and Tarik Skubal. ElAttrache’s patients include 18 of 29 players who won the MVP or Cy Young awards over the past 10 years.

“I have spoken with MLB and I am very comfortable with the process that the league and I will complete to assure the public that I have followed every rule and regulation in my medical treatment of athletes without exception,” ElAttrache said in a statement to the Los Angeles Times earlier this month. “My record is completely clean, including in this case.”

Times staff writers Steve Henson, Bill Shaikin, Sam Farmer and Gary Klein contributed to this report.

Jeremy Clarkson, the British television host best known for BBC’s “Top Gear,” revealed this week that he is battling prostate cancer.

The 66-year-old personality unveiled his diagnosis in the two most recent episodes of his farm-keeping series “Clarkson’s Farm,” which streams on Prime Video. He detailed his condition to co-hosts Kaleb Cooper and Charlie Ireland during a filmed discussion about the upcoming harvest at his Diddly Squat farm.

“I’ve got cancer,” he tells his co-stars, after informing them he will need to take some time away from his farm duties. “It’s aggressive but it’s really early.”

Clarkson also told Cooper and Ireland, who seemed visibly stunned about the health revelation, that he has known about his cancer diagnosis since May. The second part of the series’ two-part finale, released Wednesday, concludes with the “Clarkson’s Farm” crew recapping the ups and downs of their harvest year and with the show’s namesake back in a hospital bed. The season began with Clarkson discussing treatment he received for a coronary issue.

“Some of the treatment’s gone a bit awry … so I’m gonna be here for a little while,” he tells the camera crew.

He adds: “If this is all successful, I’ll see you for Season 6, and if it isn’t, I won’t. Take care everyone.”

Clarkson warned of the somber mood of the two episodes on Instagram, informing fans in a video post that they would be anything but “bucolic and charming, and cheerful.”

“They’re a difficult watch,” he says, “they’re really, really difficult.”

Before “Clarkson’s Farm” debuted in June 2021, Clarkson was best known for co-hosting BBC’s popular car show “Top Gear.” BBC fired the host after he was involved in a physical altercation with a producer. Clarkson went on to co-host “The Grand Tour” on Prime Video alongside Richard Hammond and James May, who departed “Top Gear” shortly after their co-host’s firing.

Lil Nas X says he feels “less fear in my heart” as he opens up about receiving treatment for bipolar disorder and moving forward from the mental health episode that landed him in hot water with law officials last year.

The Grammy winner (real name Montero Lamar Hill) addressed last year’s events in a video Wednesday morning on Instagram. Lil Nas X, 27, informed fans that he has been in a rehab program “for a few months,” spending time with family in Atlanta and with friends in Los Angeles. Since last year’s incident, the singer said he has been focused on “trying to ground myself down to Earth and get out of my head.”

Lil Nas X was hospitalized and arrested in August after he was seen strolling in only his underwear and white boots through Studio City, eventually shedding those items as the night progressed. The singer received treatment at a nearby hospital for a possible overdose but was accused of assaulting police officers.

He was charged with four felony counts: three counts of battery with injury on a police officer and one count of resisting an executive officer. Police accused the singer of assaulting the officers who were trying to take him into custody. Lil Nas X pleaded not guilty to all those counts.

In Wednesday’s video, Lil Nas X explained that he has also started seeing a therapist and psychiatrist to help address his mental condition — one he initially refused to accept. The singer, smiling and standing against a blue sky in his video, told fans that he was hesitant to take medication that would help address his bipolar disorder and joked that living with mental illness would add more to his plate: “I mean I’m already Black and gay…I’m like already living life on extreme hard mode.”

According to the Depression and Bipolar Support Alliance, bipolar disorder is a treatable mental health condition marked by extreme changes in mood, thought, energy and behavior. Manic episodes, marked by elevated changes in mood or behavior, are a symptom of the condition. People with a bipolar disorder diagnosis more commonly experience depressive episodes.

Lil Nas X spoke candidly about his diagnosis months after a Los Angeles judge in April granted the “Industry Baby” and “Old Town Road” singer’s motion for diversion, ordering the musician to enter a two-year mental health program. TMZ reported at the time that the musician would be cleared of his four felony counts if he complies with treatment and commits no other crimes.

The singer assured fans on Wednesday: “I’m doing better, I’m feeling better, I’m creating freely and there’s less fear in my heart and I’m just like smelling the roses.”

He also reflected on his career thus far — he quickly ascended to fame in 2019 with his viral hit “Old Town Road” — and teased that new music is on the way. Lil Nas X concluded his video by thanking fans for their support and for “holding it down.”

“I love you, and all I wanna do is continue to try to make you proud and make myself proud,” he said. “Let’s go dreamboy, let’s go.”

French activists who took part in a Gaza-bound foreign aid flotilla accuse Israeli forces of abuse and torture.

French anti-terrorism prosecutors say they have opened a preliminary investigation into suspected “torture” and “war crimes” over Israel’s alleged mistreatment of French activists who took part in a Gaza-bound aid flotilla last month.

The probe was opened on Friday following a referral from the foreign ministry late last month, said the national counterterrorism prosecutor’s office (PNAT), after activists on the Global Sumud Flotilla accused Israeli authorities of severe mistreatment during their detention.

Israel abducted and detained some 430 activists from about 40 countries after intercepting them in international waters on May 18 as they made the latest in a string of attempts to break the blockade on Gaza, which the United Nations and human rights organisations say is illegal, describing it as a form of collective punishment.

Israeli far-right National Security Minister Itamar Ben-Gvir attracted widespread condemnation after he posted a video mocking the flotilla activists while they were bound.

France banned Ben-Gvir from entry and, like several other allies of Israel, summoned the Israeli ambassador over the incident.

Several French activists described what they said was a violent and humiliating ordeal when eight of them returned to France on May 22.

Two of the more than 30 French people who were on board the flotilla were still hospitalised in Turkiye, they told reporters.

One returnee described a soldier groping and slapping her in a dark container, and being terrified that she would be raped.

Another recounted detained activists being put in what she called a “stress position”, on their knees with their foreheads on the ground for several hours, while the Israeli national anthem played on repeat.

‘Most severe case of ill-treatment’ in a decade

Speaking to Al Jazeera late last month, Suhad Bishara, legal director at Adalah, the Israeli legal centre for Palestinian rights, said that without accountability, Israel will continue to use violence against activists.

“Based on accounts received, and drawing on over a decade of representing flotilla participants, this appears to be the most severe case of ill-treatment documented in the past 10 years, potentially amounting to torture,” said Bishara.

Adalah lawyers have been informed of repeated physical violence resulting in serious injuries, prolonged stress positions, and sexual humiliation and harassment.

The Global Sumud Flotilla said it has documented at least 15 cases of sexual abuse.

Lawyers for French flotilla activists have said they plan to file a separate complaint on behalf of their clients over allegations of rape, torture and humiliation.

The activists have refused to meet with the French government to discuss their experiences, accusing it of supporting Israel’s genocidal war on Gaza.

Asked by the AFP news agency to respond to the claims of mistreatment, the Israeli prison service said the accusations were “entirely without factual basis”.

Francesca Albanese, an outspoken UN expert on the Palestinian territory, has said the treatment of the flotilla activists “is a luxury compared to what is inflicted on Palestinians in Israeli prisons”.

Scotland, Liverpool and Celtic great Sir Kenny Dalglish is undergoing treatment for cancer.

The former forward and manager wanted to keep the news private but confirmed the diagnosis after accidentally sharing the news initially in an “inadvertent social media post”.

“I am currently undergoing treatment for cancer,” Dalglish, 75, wrote on social media. “Unlike my mobile phone use, the treatment is going well.

“Ideally, this would have remained private because that’s the way it should be, but my useless technology skills have forced my hand.

“Obviously I did not mean to make this matter public so I would appreciate it if the privacy of my family and myself are respected.

“As ever, thank you to the wonderful medical staff who have shown incredible care and discretion, not just for me but for many, many others. They are a credit to themselves.”

Dalglish scored 167 goals in 320 appearances for Celtic between 1969 and 1977 before going on to make 515 appearances for Liverpool.

The legendary forward scored 30 goals in 102 caps for Scotland.

In a statement, Liverpool said: “The support, best wishes and love of everyone at Liverpool FC are, and will be, with Sir Kenny and his family.

“The club would also like to underscore his request for privacy moving forward.”

OLIVIA Attwood undergoes treatment whilst showing off risqué bum snap as she prepares for bikini season.

The stunning TV star, 35, is topping up her curves with a bum enhancing regimen amid her high-profile romance with Pete Wicks.

Taking to her Instagram Stories Olivia shared a body pic of herself hooked up to a machine at a clinic. 

The reality beauty was snapped face down as the daring bum pic revealed her covered in wires undergoing a treatment known as Truflex.

The non-invasive procedure acts as a muscle stimulant which aims to strengthen, tone, and firm the glutes.

Olivia added the caption: “We are not f****** around this season.”

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In additional text alongside the risque snap, she penned: “Truflex at @sadaf_jaffari I have had better results with this than emsculpt personally depends on your goal x”

In another one of her recent social media posts Olivia had appeared to have undergone an eye treatment with a mirror selfie showing noticeable swelling around her eyes. 

The photo dump which also showed Olivia appearing downcast in several snaps which had sparked worry with fans that there could be trouble in her relationship.

Looking downcast in one photo, Olivia pouted and didn’t look very impressed.

The images that followed were of her dogs, with a snap being of her taking a selfie in an elevator.

It also included a pic of Olivia beaming whilst getting her hair and makeup done. 

The photos had left people alarmed by the lack of Pete appearing in the post, despite the pair dating for a while now.

But it seemed all was to be good in paradise as eagle-eyed fans spotted a sign that all might be well between the pair.

One person seemed to spot Pete’s dog in one of the snaps.

“Yay to Rodney. Was hoping to spot some subtle Pete hints and also wondered if the dogs are mates with eachother! (So invested),” one person penned.

While another added: “Yes Rodney!!!!!!!”

And a third penned: “Hard launching Rodney!”

“Stitch, Lola & Rodney,” penned another, spelling out how Olivia’s pups Stitch and Lola, were now pally with Pete’s dog Rodney.

Workers in eastern DR Congo are rebuilding an Ebola treatment centre that was burned by protesters earlier this month, as health officials warn misinformation is driving families to hide sick relatives. The Congolese government confirmed over 1,000 suspected cases and at least 220 deaths since the outbreak was declared.