san francisco

Jim Harbaugh wants his teams to finish seasons the way they start them.

If the Chargers do that, they’re going all the way.

Counting his four seasons with San Francisco, Harbaugh is 6-0 in NFL season debuts as a head coach. That’s tied for the most opening victories without a loss in league history.

“It’s September. It’s time to play our first game,” Harbaugh told reporters this week. “And I support no cause, foreign or domestic, other than the greatness of the Los Angeles Chargers.”

His team plays host to the Arizona Cardinals on Sunday, and oddsmakers see a blowout in the making. The Chargers are favored by 9½ points, the biggest spread of Week 1.

Despite a 2-0 start last season, the Cardinals lost 14 of the next 15 and wound up with the third overall pick in the NFL draft, which they used on Notre Dame running back Jeremiyah Love. The rookie is questionable for this game because of an ankle injury.

Their quarterback is no longer Kyler Murray, now in Minnesota, but Jacoby Brissett, who is on his sixth franchise — and seventh if you count two stops in New England.

This game is the “Mike” drop, if you will, with Mike LaFleur coaching his first game for Arizona, and Mike McDaniel making his debut as Chargers offensive coordinator.

LaFleur and McDaniel have history. They were young offensive assistants in Cleveland, Atlanta and San Francisco and both represent branches of the Kyle Shanahan coaching tree.

There’s a link too between Harbaugh and LaFleur. Both are younger brothers of other current NFL head coaches: Matt LaFleur of the Green Bay Packers and John Harbaugh of the New York Giants.

While McDaniel and his system have been a hot topic throughout training camp, he isn’t the only new coordinator in town.

Thursday’s game will offer a similar peek at what Chris O’Leary’s starting defense has in store.

“Overall, we played together; we played fast; we played violent,” O’Leary said of the group’s performance in Houston. “The result was a good result for us. We see a lot of stuff we can clean up along the way.”

O’Leary’s defense followed up a strong opening game by playing well against the 49ers’ offense in Tuesday’s practice.

“Honestly, don’t think it was our best day,” San Francisco quarterback Brock Purdy said.

The Chargers would like to hear Purdy — who might play Thursday, according to 49ers coach Kyle Shanahan — say that again.