jab

New fat jab ‘golden dose’ is ‘safe and more effective’ – blasting nearly a FIFTH of body weight

A HIGHER ‘golden dose’ of Wegovy than is currently approved is safe and could be more effective – helping patients lose nearly a fifth of their body weight.

The once-weekly injection containing the semaglutide – also the active ingredient in diabetes jab Ozempic – is prescribed on the NHS at a maximum dose of 2.4mg.

Illustration of Wegovy boxes in different dosages.

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Wegovy is prescribed at a maximum dose of 2.4mgCredit: Reuters

Now, two major studies show that tripling doses to 7.2mg can trigger significant weight loss, without bringing on more side effects or risking patient safety.

The findings, published in The Lancet Diabetes & Endocrinology journal, suggest a higher dose of semaglutide could be an option for people with obesity – as well as type 2 diabetes – who haven’t lost enough weight on standard doses.

“Once-weekly subcutaneous semaglutide 2.4 mg is approved for weight management in people with obesity and related complications,” researchers said.

“However, some individuals do not reach their therapeutic goals with this dose.

“We aimed to test the efficacy and safety of a higher dose of semaglutide in people with obesity.”

Researchers investigated whether 7.2mg semaglutide injections could provide patients with “further benefits” and boost fat loss for people whose weight had plateaued “without jeopardising safety or significantly increasing the risk of adverse events”.

The two trials involved more than 2,000 adults with obesity, some of whom also had diabetes.

They were conducted across 95 hospitals, specialist clinics, and medical centres in 11 countries, including Canada, Germany, Greece, Norway and the US.

Researchers randomly assigned participants the 7.2mg dose, the 2.4mg dose, or placebo injections.

All participants received advice on improving diet and increasing exercise.

The new 4-in-1 weight loss drug: combining ozempic, mounjaro, and more

After 72 weeks, people without diabetes given the higher dose lost an average of 18.7 per cent of their body weight.

Those on the standard dose 15.6 per cent of their weight and those on placebo injections lost just 3.9 per cent.

Almost half of those on the higher dose lost at least 20 per cent of their body weight, while nearly a third shed 25 per cent or more.

This rivals the average weight lost with competitor jab Mounjaro, known as the ‘King Kong’ of weight loss injections.

Participants on the higher dose also saw their waists shrink and reported improvements in their blood pressure, blood sugar, and cholesterol levels – all key factors in reducing obesity-related health risks.

As for obese adults with type 2 diabetes, the 7.2mg dose caused them to lose 13 per cent of their weight.

Those on 2.4mg lost 10 per cent of their body weight on average, while placebo-users lost 4 per cent.

Both trials showed the higher semaglutide dose to be safe and generally well tolerated, though people taking 7.2mg did report more side effects.

WHO IS ELIGIBLE FOR WEIGHT LOSS JABS ON THE NHS?

NHS eligibility for weight loss injections has expanded but still lags behind the number who could potentially benefit from taking them.

Wegovy, medical name semaglutide, is only available for weight loss through specialist weight management clinics.

Patients are typically expected to have tried other weight loss methods before getting a prescription.

They may be eligible if their body mass index (BMI) is higher than 30, or higher than 27 if they have a weight-related health condition such as high blood pressure.

Mounjaro, known as tirzepatide, is also available from GP practices but currently only to patients with a BMI of 40 or higher (or 37.5 if from a minority ethnic background) plus four weight-related health conditions.

The medicines are currently being rationed to the patients most in need.

NHS watchdog NICE estimates that more than three million Brits will ultimately be eligible.

The GLP-1 injections are prescribed separately by GPs for people with type 2 diabetes, and patients should discuss this with their doctor.

“Serious adverse events” were reported by 68 of 1004 participants receiving the 7.2mg dose of semaglutide – about 7 per cent – researchers said.

Meanwhile, 22 of 201 taking 2.4mg reported side effects – about 11 per cent – and 11 of 201 receiving placebo injections, researchers said.

Nausea and diarrhoea, and some sensory symptoms like tingling, were the most common.

However, most side effects were manageable and resolved over time, researchers said.

One in 20 patients taking the higher dose stopped treatment because of side effects, similar to the standard jab.

Study authors concluded: “Semaglutide 7.2 mg was superior to placebo and semaglutide 2.4 mg in reducing bodyweight, including reaching reductions of 20 per cent or greater and 25 per cent or greater over 72 weeks.

The higher dose was “well tolerated and provided additional clinically meaningful weight loss compared with 2.4 mg, suggesting that higher doses could help patients who do not achieve sufficient weight loss with the currently approved dose”, they added.

But Professor Alex Miras, an obesity expert at Imperial College London, was more hesitant in touting the benefits of the 7.2mg dose.

He told the Daily Mail: “Tripling the dose only gives a marginal extra benefit, but the dose increase is massive.

“Going from 2.4mg to 7.2mg is a very big jump. I’m concerned many patients won’t tolerate such a high dose.

“In clinical practice people already struggle at 2.4mg.

“Even if 7.2mg is approved, I suspect uptake will be low because of cost and side-effects – the top dose is already expensive.”

It comes as many Brits taking weight loss jabs privately are priced out of paying for Mounjaro – after manufacturer Eli Lilly hiked up prices.

The highest dose was set to rise from £122 to £330 a month – an increase of 170 per cent – from September 1.

It was later reported that some pharmacies would be able to offer the jabs at a discount, saving patients £83 on the cost of the maximum dose.

But the price rise has still made Mounjaro unaffordable for many – leading Brits to switch to cheaper Wegovy or give up the jabs altogether.

In the UK, fewer than 200,000 people are thought to be accessing weight-loss jabs through the NHS, but over 1.4 million are estimated to be using them privately, according to the health think-tank the King’s Fund.

Meanwhile, jabs such as Ozempic, Wegovy and Mounjaro have been connected to 24 deaths in the 21 weeks since January, The Sun revealed.

The 7 fat jab mistakes stopping you losing weight

WHILE weight loss jabs have been hailed as a breakthrough in helping tackle Britain’s obesity crisis, some users say they’re missing out on their waist-shrinking powers – and it could be down to some simple mistakes…

POOR PENMANSHIP

Many people don’t correctly use the injection pen, according to Ana Carolina Goncalves, a pharmacist at Pharmica in Holborn, London.

Make sure to prime your weight loss pen correctly, as per the instructions. If nothing comes out, try again, and if it still doesn’t work, switch the needle or ask a pharmacist for help.

It’s also recommended to rotate injection sites between the abdomen, thigh and upper arm to avoid small lumps of fat under the skin.

TIME IS OF THE ESSENCE

Make sure you’re using the jabs on the most effective day of your schedule.

For example, taking the jab right before a takeaway or party won’t stop you from indulging, says Jason Murphy, head of pharmacy and weight loss expert at Chemist4U.

Weight loss injections need time to build up in your system, so if you’re planning for a heavier weekend, inject your dose mid-week.

MAKING A MEAL OF IT

You may not feel the urge to overeat at mealtimes due to the jabs. But skipping meals altogether can backfire, says Dr David Huang, director of clinical innovation at weight loss service Voy.

If a person is extremely malnourished, their body goes into emergency conservation mode, where their metabolism slows down.

FOOD FOR THOUGHT

A key mistake using weight loss jabs is not eating the right foods.

As well as cutting out sugary drinks and alcohol, Dr Vishal Aggarwal, Healthium Clinics recommends focusing on your protein intake.

DE-HYDRATION STATIONS

Dehydration is a common side effect of weight loss injections. But it’s important to say hydrated in order for your body to function properly.

Dr Crystal Wyllie, GP at Asda Online Doctor, says hydration supports metabolism, digestion, and can reduce side effects like headaches, nausea and constipation.

MOVE IT, MOVE IT

It can be easy to see the jabs as a quick fix, but stopping exercising altogether is a mistake, says Mital Thakrar, a pharmacist from Well Pharmacy.

Exercise helps maintain muscle mass and help shape the body as you lose weight, which may be crucial if you’re experiencing excess skin.

QUIT IT

While there’s the tendency to ditch the jabs as soon as you reach your desired weight, stopping them too soon can cause rapid regain.

Mr Thakrar recommends building habits like healthier eating during treatment for sustaining results.

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The cancer symptoms you should NEVER dismiss as fat jab ‘side effects’ – after mum given months to live

ALL medications, including prescription drugs, over-the-counter medicines, and even herbal remedies, have the potential to cause side effects.

But experts have warned weight loss jab users to pay real attention to any side effects they experience, as they could actually be signalling deadly cancer, as Dawn Clegg tragically found out.

Dawn Clegg, who has been diagnosed with the UK's rarest incurable cancer.. A mum has been diagnosed with the UK's rarest, incurable cancer after suffering chest pain she thought was from Mounjaro weight-loss jabs. Dawn Clegg, 51, began suffering from the pain in late March this year after taking the jabs which helped her deal with her diabetes. But after having several X-rays at the hospital, shadows were found on her lungs, kidneys, and breast and she was later diagnosed with a soft-tissue cancer known as sarcoma. Photo released 20/07/2025

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Dawn Clegg initially put her chest pain down to a side effect of the ‘King Kong’ of fat jabs, Mounjaro
Photo of Arron and Dawn Clegg.

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Dawn, pictured with husband Arron, was given less than a year to live after doctors discovered a soft-tissue cancer known as sarcomaCredit: SWNS
Close-up of a person self-administering a semaglutide injection.

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Like all medications, fat jabs have the potential to cause side effects – but many can mask various deadly cancers, experts tell Sun HealthCredit: Getty

The 51-year-old, from Morecambe, Lancashire, had been using Mounjaro to treat her diabetes, but in March this year, she began suffering from chest pain, which she initially put down to a side effect of the jabs.

When the pain persisted, she headed to A&E before doctors made a shocking discovery.

After undergoing several X-rays, doctors spotted shadows on her lungs, kidneys and breast, and she was diagnosed with soft-tissue cancer, known as sarcoma.

Dawn was then given the life-shattering news that she had less than a year to live.

Her heartbroken husband, Arron Clegg, 51, is planning to hold a “living wake” in November to celebrate the life of his wife.

He said: “We were devastated on hearing news of cancer in these areas – there is no cure and she is now terminal.”

Weight loss expert at The Lagom Clinic, Dr Jack Ogden, said he has also been made aware of a fat jab user mistaking symptoms of cancer for side effects, though they weren’t linked to the clinic.

He tells Sun Health: “As a clinician, hearing about cases like this is always sobering. It reinforces how easy it is for both patients and healthcare professionals to attribute symptoms to the most obvious cause.

“In this case, weight loss injections, when something more serious may be underlying.”

The fat jab user, a 52-year-old who remains anonymous, began experiencing persistent fatigue, feeling full quickly, and mild nausea while on a GLP-1 weight loss injection.

Weight Loss Jabs – Pros vs Cons

They initially assumed these symptoms were routine side effects, but they persisted beyond the expected two to three-week adjustment period.

Further investigation by their GP revealed a diagnosis of stage two stomach cancer – which isn’t very common in the UK but can be deadly.

When detected early, stomach cancer has a high chance of being cured.

But it’s often diagnosed at a more advanced stage, which makes it harder to treat and means survival rates can be low.

Dr Ogden said: “It’s important to monitor persistent symptoms, keep a log of side effects, and seek prompt medical advice if anything unusual arises.”

So what cancer symptoms could people mistake for the side effects of fat jabs?

Here, a team of experts offer their life-saving advice…

THE SYMPTOMS YOU MUST NOT IGNORE

Illustration showing possible cancer symptoms related to fat jab side effects.

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THERE are more than 200 different types of cancer, and they all have different signs and symptoms.

While some affect specific areas of the body, symptoms can be more general and similar to those caused by less serious conditions or medication side effects.

Superintendent pharmacist at pharmica.co.uk, Ana Carolina Goncalves, said symptoms such as persistent indigestion, heartburn and abdominal pain are potential side effects of weight loss injections, but could also be signs of liver, bladder, pancreatic or stomach cancer.

She says: “Thyroid swelling or a lump in the neck might be dismissed as an injection side effect, but it could also indicate thyroid cancer.

“The risk of thyroid swelling has been confirmed as a potential side effect by the manufacturers of both Mounjaro and Wegovy.

“And nausea is another common side effect of weight loss jabs that can also indicate liver, bladder or pancreatic cancer.

“There’s a lot of overlap between the symptoms of different organ cancers (like liver and pancreatic cancer) because they affect similar areas of the body.

“This can make identification of cancer symptoms difficult, especially when side effects of weight loss injections are also present.”

It’s also important to note that while use of the jabs results in weight loss, sudden, unexplained, unintentional, and significant (more than 5 per cent of your body weight in six to 12 months) weight loss could be a red flag for cancer.

HOW TO SPOT THE DIFFERENCE

THERE’S not always an easy way to tell the difference between cancer symptoms and weight loss side effects.

It depends on the symptoms you experience, says Ms Goncalves.

She explains: “High levels of acid reflux or heartburn that persist even after you’ve stopped weight loss injections should definitely be looked into by a doctor or GP.

“Also, a lump in the neck, hoarseness, or difficulty swallowing could indicate thyroid cancer.

“It’s not possible to fully tell on your own, so you should consult your doctor or GP if you experience these symptoms.”

WHAT’S THE RISK?

Doctor holding a patient's hand and reviewing notes.

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Mistaking cancer symptoms for medication side effects could lead to a delay in diagnosisCredit: Getty

KEVIN Joshua, clinical lead at Juniper, an online healthcare provider, says while it’s not very common, confusing symptoms and side effects are a real risk.

He warns: “The danger is that someone may put persistent or worsening symptoms down to the medication, rather than seeing their GP.

“That missed time can make all the difference in cancer treatment and survival.”

Ms Gonclaves adds: “Cancer caught early is far easier to treat. If people assume ongoing pain, nausea or weight loss is just a side effect, they may only get checked once the cancer is more advanced – and that can be life-threatening.

“Given the increasing use of weight loss injections in the UK, the potential for confusion is likely growing, especially for cancer symptoms that overlap with common injection side effects.

“However, there’s currently no large-scale study that estimates how frequently cancer symptoms are misattributed to jabs.

“But it’s important to note the safety of Wegovy and Mounjaro has been proven in clinical trials, and they are licensed by the Medicines and Healthcare products Regulatory Agency (MHRA) for weight management in the UK.”

WHAT SHOULD YOU DO?

IF you experience any symptoms after starting weight loss jabs, Dr Ogden recommends you do the following:

  1. Track your symptoms – keep a daily log noting timing, intensity, and duration.
  2. Monitor persistence – common side effects usually settle within two to three weeks.
  3. Note severity changes – sudden worsening or new symptoms are red flags.
  4. Consult a healthcare professional promptly – don’t wait to see if symptoms pass if they are unusual or severe.
  5. Communicate openly – share your symptom log with your GP or specialist for accurate assessment.

Weight loss injections can be safe and effective, but awareness and careful monitoring are essential, added Dr Ogden.

“Early detection of serious issues can save lives and prevent complications.”

The majority of common side effects, such as nausea, diarrhoea, vomiting, skin redness or fatigue, can be managed with adequate hydration, dietary choices, and over‑the‑counter medication.

Ms Goncalves advises: “You can try eating smaller meals, and using herbal teas or oral rehydration salts to alleviate gastrointestinal symptoms.

“You should drink fluids regularly to ensure you are hydrated.”

But you should seek medical help if symptoms are severe, continue for more than a few weeks, or are linked with alarm signs like vomiting blood, blood in stools, jaundice, unexplained weight loss or a lump.

“These should never be written off as ‘just the jab’,” said Mr Joshua.

THE MOST COMMON CANCERS IN THE UK TO BE AWARE OF

THE most common cancers in the UK are breast, prostate, lung, and and bowel cancer.

Breast cancer is the most common cancer in the UK, affecting both men and women but far more common in women. 

Symptoms include a new lump or thickening in the breast or armpit, changes in breast size or shape, nipple changes like inversion or discharge (especially with blood), skin changes such as dimpling, redness, or a rash, and persistent pain. 

Prostate cancer is the most common cancer in men.

 Symptoms primarily involve urinary and sexual issues, such as frequent or urgent urination (especially at night), difficulty starting or stopping urine flow, a weak stream, and a feeling of incomplete bladder emptying.

Lung cancer is a leading cause of cancer deaths in the UK, linked to smoking.

Common lung cancer symptoms include a persistent cough, coughing up blood, breathlessness, an unexplained cough that gets worse, chest pain or ache, recurring chest infections, and unexplained weight loss or fatigue.

And bowel cancer is a common cancer affecting both men and women.

Symptoms can include a persistent change in bowel habits, blood in your poo or bleeding from the bottom, unexplained weight loss, unexplained tiredness, and a pain or lump in your tummy.

Early diagnosis can significantly improve outcomes for most cancers, so if you experience any of these symptoms, see your GP.

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After Trump jab, India’s Modi says ties with US still ‘very positive’ | Narendra Modi News

Indian leader’s remarks follow Trump reaffirming their personal friendship and downplaying his earlier remarks about ‘losing India’ to China.

Indian Prime Minister Narendra Modi says ties with the United States remain “very positive”, after US President Donald Trump reaffirmed their personal friendship and downplayed earlier remarks about “losing India” to China.

“Deeply appreciate and fully reciprocate President Trump’s sentiments and positive assessment of our ties,” Modi said in a statement posted on X on Saturday, adding that India and the US “have a very positive and forward-looking comprehensive and global strategic partnership”.

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Strains have emerged between the two longtime allies after the Trump administration imposed tariffs of up to 50 percent on Indian imports, accusing New Delhi of fuelling Moscow’s deadly attacks on Ukraine by purchasing Russian oil.

Speculation of a deepening rift further intensified when Trump remarked on Friday that India, alongside Russia, seems to have been “lost” to China. This came after Modi and Russian President Vladimir Putin met with Chinese President Xi Jinping during a security summit in China.

Earlier this week, Xi hosted more than 20 leaders of non-Western countries – including Modi and Putin – for the Shanghai Cooperation Organisation (SCO) summit in the Chinese port city of Tianjin. It was Modi’s first visit to China in seven years, signalling a thaw between the two Asian powers.

“Looks like we’ve lost India and Russia to deepest, darkest, China. May they have a long and prosperous future together!” Trump wrote in a social media post, with a photo of Modi alongside Xi and Putin.

When asked by reporters later on Friday about his remarks, Trump downplayed his earlier statement, saying he did not think the US had lost India to China.

“I don’t think we have,” he said. “I’ve been very disappointed that India would be buying so much oil, as you know, from Russia. And I let them know that.”

Trump insisted that he “will always be friends with Modi”, adding that “India and the United States have a special relationship“. “There is nothing to worry about,” he said.

Since his first term in office, Trump and Modi, both right-wing populists, have shared a strong bond.

But recently, Trump also appeared irritated at New Delhi as he sought credit for what he said was Nobel Prize-worthy diplomacy for brokering peace between Pakistan and India following the worst conflict in decades between the nuclear-armed neighbours in May.

India, which adamantly rejects any third-party mediation on Kashmir, has since given the cold shoulder to Trump on the matter.

Trump has also been frustrated at his inability to convince Russia and Ukraine to reach an end to their war, more than three years after Russian forces invaded Ukraine.

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I invented fat jab… why there could be a HUGE undiscovered benefit for women & dangerous problem with super-thin celebs

IT was 1984 and newly qualified doctor Daniel Drucker was excited to dive into the world of ­scientific research.

Fresh out of the University of Toronto Medical School, the 28-year-old was working at a lab in Boston in the US when his supervisor asked him to carry out a routine experiment — which proved to be anything but.

Researcher standing in a lab.

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Dr Daniel Drucker says he would not rule out using jabs in the future if they proved to be effective against Alzheimer’s diseaseCredit: Supplied
Lottie Moss in a black cutout outfit.

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Model Lottie Moss was taken to hospital last year after a seizure linked to high doses of weight-loss drug OzempicCredit: instagram

For it led to Dr Drucker’s discovery of a previously unknown hormone, sparking a new era in medicine.

What he modestly calls a “happy accident” then kick-started a series of ­discoveries that made today’s game-changing weight loss jabs a reality.

The hormone was called glucagon-like peptide 1 — or GLP-1, as the world now knows it.

And the drugs that have resulted from its discovery have produced amazing effects — with users losing up to a fifth of their body weight.

So far around 50,000 of us have been prescribed jabs on the NHS for weight loss, but it is ­estimated around 1.5million people here are buying them privately — a figure that is expected to rise sharply.

Dr Drucker, now 69, tells The Sun: “I never felt like I was on the brink of something huge.

“It was just a fantastic stroke of luck to be in the right place at the right time and to be part of an ­innovation that could improve the health of hundreds of millions of people all over the world.”

The drugs are now being hailed as a possible cure for a range of other conditions too, including dementia and migraine.

But Dr Drucker warns: “We need to be cautious, respect what we don’t know, and not rush into thinking these medicines are right for everyone.

‘Full of hope’

“There could be side-effects we haven’t seen yet, especially in groups we haven’t properly studied.”

I had weight regain and stomach issues coming off fat jabs

Some studies have also raised concerns about gallbladder problems and in rare cases, even ­suicidal thoughts.

GLP-1 was found to play a key role in regulating the appetite and blood sugar levels, by slowing digestion and signalling a feeling of fullness to the brain.

Fat jabs such as Mounjaro and Wegovy contain synthetic versions of GLP-1, tirzepatide and semaglutide, which mimic the natural hormone with astonishing, fat-busting results.

Originally these drugs — known as GLP-1 agonists — were licensed to treat Type 2 diabetes, due to their ability to stimulate the body’s production of insulin, which cuts high blood glucose levels.

But over the past 15 years, after studies ­confirmed the potential to tackle obesity, pharmaceutical firms have reapplied to have the drugs approved as weight loss treatments.

And now evidence is emerging almost daily to suggest these drugs could help treat and even prevent other chronic and degenerative diseases.

Hundreds of scientific trials are under way, and Dr Drucker is “full of hope”, adding that he would consider taking the drugs himself, to ward off ­Alzheimer’s disease.

He says: “I think the next five years is going to be massive. These drugs won’t fix everything, but if they help even half the ­conditions we are testing them for, we could finally find ­treatments for conditions once thought untreatable.”

Decades after his discovery, Dr Drucker is now a professor of ­medicine at the University of Toronto, and a senior investigator at the affiliated Lunenfeld-Tanenbaum Research Institute, where GLP-1 research now fills his life.

He says: “Every morning I turn on my phone and check what’s happened overnight — what new ­discovery has been made, what could this hormone cure or treat.”

Even so, in May UK health chiefs warned that the jabs must not be taken during pregnancy or in the two months before conception, after studies of animals found that semaglutide can cause ­pregnancy loss and birth defects.

But with human use, no such ­danger has been ­confirmed, Dr Drucker says, and dozens of women have ­conceived while taking them.

Scientist in lab coat operating lab equipment.

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Dr Drucker’s pioneering work led to fat jabs that have become a medical game-changer
Close-up of a person injecting semaglutide into their abdomen.

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The drugs are now being hailed as a possible cure for a range of other conditions too, including dementia and migraineCredit: Getty

Some scientists even believe GLP-1 drugs may boost ­fertility, and could become a go-to for infertility treatment.

Dr Drucker, listed in Time magazine’s 100 Most Influential People in 2024, says: “It wouldn’t surprise me if five years from now, once we have more clinical trial evidence, if we start recommending these medicines to help people get pregnant, and have safer pregnancies.”

It is exciting stuff, but Dr Drucker admits he also worries about people using the drugs for the wrong ­reasons — such as slim, young women in pursuit of unrealistic beauty ideals on social media.

He says: “If I’ve got a 17-year-old who wants to lose another five per cent of her body weight to look like some celebrity, that’s a real concern.

“We haven’t studied 10,000 teenage girls on these drugs over five years. We don’t know how they affect bones, fertility, mental health or development in the long term.”

Last year model Lottie Moss, sister of supermodel Kate, revealed she had ended up in hospital after a seizure linked to high doses of weight loss drug Ozempic.

I think the next five years will be massive. These drugs won’t fix everything, but if they help even half the conditions we are testing for, we could find treatments for conditions thought untreatable

Dr Daniel Drucker

A nurse told her the dose she had been injecting was meant for someone twice her size.

Dr Drucker warned that older adults, people with eating disorders and those with mental health ­conditions may respond differently to the drugs.

He says: “We’re still ­learning, and just because a medicine works well in one group doesn’t mean it is safe for everyone.”

One of the biggest risks is dehydration, which OnlyFans star Lottie blamed for her seizure.

Dr Drucker says: “Some people experience nausea and vomiting, which can lead to dehydration, and that in itself can be dangerous.”
He also warns that losing weight too quickly can reduce muscle mass and bone density, which is especially risky for older people.

He adds: “This is why it is important people only take these drugs when being monitored by medical professionals, so they can be properly assessed for side-effects and receive the safest, most effective care.”

Cheryl Rosen and Daniel J. Drucker at the Breakthrough Prize Ceremony.

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Dr Drucker with his fellow medic wife Dr Cheryl Rosen, a dermatologistCredit: Getty

So far at least 85 people in the UK have died after taking weight loss jabs, according to reports sent to the Medicines and Healthcare Products Regulatory Agency watchdog.

While none of the deaths has been definitively linked to the drugs, health bodies noted a “suspicion” that they may have played a role.

Dr Drucker says: “Reports like these can raise flags, but without proper comparison groups they don’t tell the full story.

‘Drugs aren’t candy’

“In fact, large trials show GLP-1 drugs actually reduce death rates in people with Type 2 diabetes and those with obesity and heart disease.

“So far, the evidence looks solid and reassuring.”

With millions of patients treated over the years, GLP-1s have a well-established safety record for diabetes and obesity.

But Dr Drucker warns that for newer uses, such as ­Alzheimer’s, fatty liver disease or sleep apnoea, we need more data.

He says: “I don’t think there are any hidden, terrifying side-effects waiting to be uncovered.

“But that doesn’t mean people should take them lightly. We don’t yet have 20 years of experience ­treating some of these ­conditions.

“We need to approach each new indication with appropriate caution, to really understand the benefits ­versus the potential risks.

“These drugs aren’t candy, they won’t fix everything — and like all medicines they have side-effects.

“I don’t think we should abandon our focus on safety. We need to move carefully and thoughtfully as this field evolves.”

I’m not struggling with Type 2 diabetes or obesity, but I do have a family history of ­Alzheimer’s. I’m watching the trials closely and, depending on the results, I wouldn’t rule out taking them in the future

Dr Daniel Drucker

He continues: “I’m not struggling with Type 2 diabetes or obesity, but I do have a family history of ­Alzheimer’s. I’m watching the trials closely and, depending on the results, I wouldn’t rule out taking them in the future.

“I have friends from college who are already showing early signs of cognitive decline, and there’s hope that in some cases, ­semaglutide might help to slow it.”

Several studies over the years ­support that theory.

A recent study by a US university found that the jabs could prevent Alzheimer’s-related changes in people with Type 2 diabetes.

Separate research from Taiwan found that people on GLP-1 agonist drugs appeared to have a 37 per cent lower risk of dementia.

Dr Drucker now regularly receives messages from people around the world whose lives have been changed by the drugs his lab helped to create.

He says: “I get tons of stories. ­People send me emails and photos, not just showing their weight loss, but how their health has changed in other ways too.”

Some say the jabs have helped their chronic pain, cleared brain fog or improved long-standing health conditions such as ulcerative colitis or arthritis.

Dr Drucker adds: “It’s incredibly heartwarming and I never get tired of hearing these stories.”

But for him there is even deeper meaning attached to his discovery.

His 97-year-old mother Cila, ­originally from Poland, survived the Holocaust, spending months as a child hiding in the family’s attic before they were captured and held in a ghetto, where her mother and sister were later shot dead.

At the end of the war in 1945 she became a refugee in Palestine, then in 1953 she emigrated to Canada, first settling in Montreal then making Toronto her home in the 1990s.

Dr Drucker says his work has helped to ease Cila’s survivor’s guilt which had consumed her for decades.

He says: “She looks at my work and she’s so proud of how many people it could potentially help.”

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From brain swelling to stroke and killer infections – how chickenpox can prove fatal as new NHS jab offered to millions

CHICKENPOX has gained a reputation as a ‘harmless’ childhood illness that it’s best to get over with – but it could result in dangerous complications for some and may even prove fatal.

It was announced that children will be given chickenpox vaccines for free on the NHS for the first time from January 2026.

The jab is already used in the US, Canada, Australia and Germany.

One to three-year-olds in the UK will receive the chickenpox vaccine along with the measles, mumps and rubella (MMR) jab.

The combined vaccine will now be dubbed MMRV, as it will protect against the varicella zoster virus.

Responding to news of the chickenpox vaccine rollout in the UK, Dr Gayatri Amirthalingam, from the UK Health Security Agency, said: “For some babies, young children and even adults, chickenpox can be very serious.

“It is excellent news that we will be introducing a vaccine. It could be a lifesaver.”

The news was coupled with warnings from experts that nearly one in five school-starters are not fully protected against preventable diseases – with uptake for the four-in-one diphtheria, tetanus, polio and whooping cough booster and MMR jabs having dropped again.

Chickenpox is a highly contagious infection known for its telltale itchy, spotty rash that blisters and scabs over.

But before these spots appear, the virus can also cause a high temperature, aches and pains, and loss of appetite.

Though it’s mostly known to infect children, adults can also catch chickenpox if they didn’t pick it up in childhood.

These infections tend to be more severe and adults with a varicella infection are more likely to be admitted to hospital.

How getting vaccinated protects the most vulnerable among us

Most people will recover on their own within a week or two, but the infection can be serious, even life-threatening, for some – especially if they’re very young or old, pregnant or have a weakened immune system.

The illness can result in bacterial skin infections and in rare cases, pneumonia, brain swelling and stroke.

For some, these complications can be fatal.

An average of around 20 people die of chickenpox per year, according to the Vaccine Knowledge Project at the University of Oxford.

This ranges from 17 deaths in 2017, to four in 2020, according to Office for National Statistics data.

Eighty per cent of deaths from chickenpox infections in England and Wales occur in adults, the National Institute for Health and Care Excellence (NICE) states.

1. Bacterial infections

Chickenpox spots can appear anywhere on the body – including inside the mouth and around the genitals.

They tend to develop into fluid-filled blisters, before bursting and scabbing over, which can take a few days.

The spots tend to be maddeningly itchy, so it can be hard to resist the temptation of scratching them – though soothing creams and cool baths can help.

Chickenpox symptom timeline

The main symptom of chickenpox is an itchy, spotty rash anywhere on the body.

Before or after the rash appears, you might also have:

  • A high temperature
  • Aches and pains, and generally feel unwell
  • Loss of appetite

Chickenpox happens in three stages, but new spots can appear while others are becoming blisters or forming a scab.

Stage 1: Spots appear

The spots can:

  • Be anywhere on the body, including inside the mouth and around the genitals, which can be painful
  • Spread or stay in a small area
  • Be red, pink, darker or the same colour as surrounding skin, depending on your skin tone
  • Be harder to see on brown and black skin

Stage 2: Spots become blisters

The spots fill with fluid and become blisters. The blisters are very itchy and may burst.

Stage 3: Blisters become scabs

The spots form a scab, some are flaky, while others leak fluid.

It usually gets better on its own after one to two weeks without needing to see a GP.

Source: NHS

Sometimes the chickenpox spots can get infected with bacteria – probably from scratching, according to healthcare provider Bupa.

Signs of a bacterial infection include a high temperature and redness and pain around the chickenpox spots.

You should seek urgent medical help if you or your child develop these symptoms.

2. Dehydration

Young children do run the risk of becoming dehydrated due to chickenpox.

For babies and kids, fewer wet nappies and peeing less can be telltale signs of dehydration.

Other signs may include:

  • Feeling thirsty
  • Dark yellow, strong-smelling pee
  • Feeling dizzy or lightheaded
  • Feeling tired
  • A dry mouth, lips and tongue
  • Sunken eyes

Call NHS 111 if you suspect you or your little one are dehydrated from chickenpox.

3. Pneumonia

Some people – especially adults – can develop pneumonia, inflammation of the lungs, after being infected with chickenpox.

Pneumonia is the most common chickenpox complication in adults, according to NICE.

Smokers are particularly at risk.

Symptoms of pneumonia can include:

  • A cough with yellow or green mucus
  • Shortness of breath
  • A high temperature
  • Chest pain
  • An aching body
  • Feeling very tired
  • Loss of appetite
  • Making wheezing noises when you breathe
  • Feeling confused

4. Brain swelling

Infection or swelling of the brain, known as encephalitis, is a rare complication of the chickenpox infection.

Professor Benedict Michael, Institute of Infection, University of Liverpool, said: “Varicella-zoster virus is the second leading cause of brain infection (or ‘encephalitis’) in the UK, which can be life-threatening.

“Early diagnosis and treatment are essential, but prevention through vaccination is the most effective way to protect children and families from this serious complication.”

Dr Ava Easton, Chief Executive of Encephalitis International, added: “By making [the chickenpox vaccine] available to every child, we’re not only reducing the spread of chickenpox but also helping to stop some families from ever facing the devastating impact of encephalitis.

“That’s a powerful step forward for children’s health and for awareness of a condition too few people know about.”

Encephalitis usually starts off with flu-like symptoms, such as a high temperature and headache.

More serious symptoms develop in the next few hours, days or weeks, including:

  • Confusion or disorientation
  • Seizures or fits
  • Changes in personality and behaviour
  • Difficulty speaking
  • Weakness or loss of movement in some parts of the body
  • Loss of consciousness

Dial 999 for an ambulance immediately if you or someone else has these serious symptoms.

5. Stroke

According to the Stroke Association, children who develop chickenpox may have a four times higher risk of stroke in the six months following infection.

“However, stroke in children is still rare and the finding translates into a very small actual increase in their stroke risk,” it noted.

Studies by the organisation also found that adults with shingles – also caused by the varicella zoster virus – may also have an increased risk of stroke up until six months afterwards.

“This is particularly within the first few weeks, and for individuals with shingles around the eye,” Stroke Association said.

“Oral antiviral drugs used to treat shingles may be able to reduce this risk.”

What are the symptoms of stroke?

The FAST method – which stands for Face, Arms, Speech, Time – is the easiest way to remember the most common symptoms of stroke:

F = Face drooping – if one side of a person’s face is dropped or numb then ask them to smile, if it’s uneven then you should seek help.

A = Arm weakness – if one arm is weak or numb then you should ask the person to raise both arms. If one arm drifts downwards then you might need to get help

S = Speech difficulty – if a person’s speech is slurred then this could be a sign of a stroke

T = Time to call 999 – if a person has the signs above then you need to call 999 in the UK or 911 in the US for emergency care.

Other symptoms include:

  • sudden weakness or numbness on one side of the body
  • difficulty finding words
  • sudden blurred vision or loss of sight
  • sudden confusion, dizziness or unsteadiness
  • a sudden and severe headache
  • difficulty understanding what others are saying
  • difficulty swallowing

6. Sepsis

In rare cases, chickenpox can result in sepsis – when the body’s immune system overreacts to an infection, attacking its own tissues and organs.

Sepsis can be life threatening and requires immediate medical help.

It can also be hard to spot, as there are lots of possible symptoms.

In adults, remember the SEPSIS acronym:

  • Slurred speech or confusion
  • Extreme shivering or muscle pain
  • Passing no urine (in a day)
  • Severe breathlessness
  • It feels like you’re going to die
  • Skin mottled, discoloured, or cold

Other signs include:

  • High or very low body temperature
  • Rapid heart rate
  • Low blood pressure
  • Rapid breathing

In children, look out for: 

  • Fast breathing
  • Lethargy or difficulty waking up
  • Mottled, pale, or bluish skin
  • Very cold hands and feet
  • Seizures
  • A rash that doesn’t fade when pressed ,which is a sign of meningococcal sepsis
  • Babies not feeding or vomiting 

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Mounjaro weight loss jab available at GPs

Smitha Mundasad

Health reporter

Getty Images White injector pen with clear fluid in, held in two hands against a white background with shadowsGetty Images

Weight loss injections like Mounjaro and Wegovy are available in specialist weight loss clinics

Prescriptions for Mounjaro jabs, to help people lose weight, will be available at GP surgeries in England from today – but only for those who meet very strict criteria.

NHS England says while the long-term plan is for the jabs to be more widely available, a staggered approach is needed to reach those most at need, manage GPs’ workload and NHS resources.

The weekly injection makes you feel full so you eat less, and can help people lose 20% of their body weight.

GPs say they don’t have enough doctors to deal with demand for the medicine and are urging people not to approach their local surgery unless they are eligible.

Mounjaro, or tirzepatide, was initially licensed to help treat type 2 diabetes, but is now also prescribed to help those with obesity lose weight.

Who is eligible for Mounjaro from GPs right now?

According to NHS England, the first group of patients who will be able to get the jab from their GP or a community clinic, will be those most in need.

This is people with:

  • a BMI of 40 or over (or 37.5 if from a minority ethnic background)
  • and four out of five of the following conditions: type 2 diabetes, high blood pressure, heart and vascular disease, high cholesterol and obstructive sleep apnoea

People will also get “wrap-around” care – including regular check-ups, support with exercising and advice on eating healthily, for example.

But prescriptions for the drug will not necessarily be available from all local GPs. In some cases, they will come from other primary care services.

NHS England says people should check their integrated care board (ICB) website for more information. (That’s the organisation that is responsible for planning the health services for a local population).

Dr Claire Fuller, co-national medical director of primary care at NHS England, says greater access to weight-loss drugs will make a “significant difference to the lives of people living with obesity and experiencing severe ill health”.

“This is an important next step in the rollout of weight-loss drugs, with community-based services now able to offer this treatment from today,” she said.

But some GP practices have issued notices on their websites saying very few patients on their lists will qualify for the medicine straight away. One GP surgery is asking for patience while community services are set up.

Prof Kamila Hawthorne, chair of the Royal College of General Practitioners, said weight loss injections do work but GPs are “over-burdened” already and don’t have a big enough workforce to deal with demand.

“It’s a lot safer to come to us than buying online or over the counter, but we are asking people not to approach GPs unless they think they meet the criteria,” she added.

Will I get Mounjaro if I meet the criteria?

It is unlikely all patients who want Mounjaro and meet the criteria, will get it straight away, according to the trade association for large pharmacies, the Company Chemists’ Association.

Chief executive Malcolm Harrison said although the medicines are likely to “transform the lives” of millions, “it is unlikely that the planned GP provision will be sufficient to meet patient demand”.

And weight loss jabs are relatively new in healthcare terms. Some GPs and other healthcare staff need training in how to offer them safely and appropriately.

Mounjaro also requires monthly check-ups for patients during the first few months of taking it, making this a labour intensive process for doctors.

Surgeries will also be looking at their capacity to provide the wrap-around care needed alongside the injection.

Then there will be those who can’t take Mounjaro right now – for example, women who are pregnant, trying to become pregnant or breastfeeding.

People who have had certain conditions – like pancreatitis or certain thyroid tumours should not take the drug either.

Individuals will need to have a chat with their GP or clinic to weigh up the potential side-effects too.

Where else is Mounjaro available?

Mounjaro has been available in specialist NHS weight loss clinics since March.

Wegovy, also known as semaglutide, is another weight loss jab which works in a similar way. It can be prescribed to certain groups of people under the care of specialist NHS weight loss management clinics.

Both medicines can also be bought privately.

Dr Claire Fuller, of NHS England, says not everyone will be eligible for weight loss drugs.

“It’s important that anyone who is worried about the impact of their weight on their health discusses the range of NHS support available with their healthcare professional,” she explained.

When can I get Mounjaro if I don’t fit the criteria right now?

Interim guidance from NHS England suggests Mounjaro will be available to some 220,000 people over the next three years.

Their current plan suggests it may be available in phases:

  • June 2026: expanded to include people with a BMI of 35 to 39.9 who have four out of five conditions listed above
  • April 2027: also offered to people with a BMI of 40 and above who have just three out of five conditions listed above

The health watchdog, NICE, will then take stock of how the rollout has been going and decide if it is the right to time to offer it to more people with obesity.

Around 3.4 million people are likely to be eligible over the next 12 years, estimates suggest.

What about the rest of the UK?

Mounjaro is available through specialist weight management services in the NHS in Wales. The Welsh government is considering other arrangements, including involving primary care, in the future.

In Northern Ireland, a new regional obesity management service will be introduced gradually over the next few years, with a community-based service where patients will have access to lifestyle support and obesity medication if appropriate.

Very few people are currently being prescribed drugs for weight loss on the NHS in Scotland, research by BBC Scotland News has established. In Scotland, health boards make decisions on which medicines are available in their areas.

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