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Hooker Jamie George, wing Tom Roebuck and centre Ollie Lawrence have been ruled out of Sunday’s match against Argentina as England’s tough autumn stretches the squad.

All three started the 33-19 win over New Zealand last weekend, but George and Lawrence picked up hamstring injuries while Roebuck has a foot problem.

Two other regulars, lock Ollie Chessum and centre Tommy Freeman, are again unavailable after missing the victory over the All Blacks.

Hooker Jamie Blamire, second row Charlie Ewels and uncapped teenage wing Noah Caluori come into the squad as Steve Borthwick’s side target an unbeaten autumn.

Caluori, who was named in England’s initial autumn internationals squad, scored in England A’s win over Spain on Saturday.

Argentina are in London this week after cruising past Wales and then coming back from a big deficit to stun Scotland in Edinburgh last Sunday.

Fly-half George Ford, who masterminded a 2-0 series win in Argentina in the summer, says England will be expecting a tough time against the Pumas.

“I know first-hand from being there in the summer how good a team Argentina are,” Ford told BBC Sport.

“They are an incredible, emotional and passionate team and we will have to make sure we get our prep right for that.”

Meanwhile, full-back Freddie Steward is available for selection despite failing a head injury assessment in the first half against the All Blacks.

The Rugby Football Union says Steward passed both his second and third HIAs, so is cleared to play this weekend.

British and Irish Lion Mack Hansen has been recalled to the Ireland squad for the side’s remaining autumn Tests but Jamie Osborne will miss out with a shoulder injury.

Ireland are back in action against Australia on Saturday in Dublin (20:10 GMT) before taking on world champions South Africa at Aviva Stadium on Saturday, 22 November (17:40 GMT).

Connacht’s Hansen has rejoined the squad despite initially being considered out for the autumn series because of the foot injury he picked up in his side’s United Rugby Championship loss to the Bulls last month.

Hansen has never started at full-back for Ireland, although his past four Connacht appearances have been in the position, but with usual starter Hugo Keenan also out the former Brumbies player gives head coach Andy Farrell another option in his back three.

Osborne wore the 15 jersey against New Zealand and Japan to start the month but was replaced by Jimmy O’Brien in the second half of the 41-10 win over the latter on Saturday and Farrell said afterwards that his shoulder injury did not “look good”.

Hansen’s club-mate Darragh Murray has also been called into the squad with the second row capped during the summer tour to Georgia and Portugal.

Leinster pair Garry Ringrose and Josh van der Flier remain doubts for this weekend’s game against the Wallabies with hamstring strains and their progress will be monitored before the team is announced on Thursday.

There is better news on the injury front with centre Stuart McCloskey making progress with a groin injury sustained against the All Blacks and expected to take a full part in training this week.