Tino Livramento, Kobbie Mainoo, Cole Palmer, Marcus Rashford and Declan Rice have all pulled out of England’s squad for forthcoming Nations League matches.
Nottingham Forest midfielder Morgan Gibbs-White and Everton‘s James Garner have been called into the squad by manager Thomas Tuchel and will join the squad on Tuesday.
Tuchel said on Friday that 26-year-old Gibbs-White, who has six international caps, was close to being included in the initial squad.
Palmer, 24, had been recalled by Tuchel after being controversially left out of England’s World Cup squad but has withdrawn with a minor injury.
Tuchel previously said Palmer had a “point to prove” and needed “to step up” to “keep his shirt and justify the nomination”.
The Three Lions face World Cup winners Spain at Wembley on Saturday, 26 September, then travel to the Czech Republic (29 September) and Croatia (3 October) before hosting the Czechs on 6 October in an extended international break.
Manchester United duo Rashford and Mainoo were assessed by their club after being taken off in the closing stages of Sunday’s 1-1 draw at Fulham.
Rice, who played the full game for Arsenal in their 3-0 defeat by Brighton, will also be unavailable to Tuchel, along with Livramento, who has been limited to three substitute appearances for Newcastle United this season.
The England medical department and all their counterparts at each of the clubs have agreed the five players can withdraw. No specific details have been released to the media on the nature of the injuries.