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Was the Chargers’ loss to the previously winless New York Giants a mere blip or an omen of what life’s going to be like with a patchwork offensive line?

Sunday’s game will be a test of that, because even though the Washington Commanders aren’t quite as imposing along the defensive line, they can still rush the passer.

The Chargers defense has been playing well but tends to struggle with mobile quarterbacks. Enter Commanders quarterback Jayden Daniels, last season’s Offensive Rookie of the Year who is recovering from a sprained knee. He won’t have his top receiver, Terry McLaurin, who is dealing with a quadriceps injury.

Meanwhile, Chargers receiver Keenan Allen needs two catches to reach 1,000 for his career, and has a chance to hit that milestone in fewer games than anyone in NFL history. This will be his 159th game. Hall of Famer Marvin Harrison has the record, collecting his 1,000th catch in his 167th game.

How the Chargers can win: Protect Justin Herbert. Get the ground game going with rookie Omarion Hampton. Gap discipline — this defense doesn’t handle scrambling quarterbacks well, and nobody scrambles better than Daniels.

How the Commanders can win: Eliminate or at least limit the explosive plays, a weakness of the Commanders defense. Keep that running-back-by-committee approach rolling against a defense that gave up 161 yards rushing last week. Let Daniels use his legs for big yards on unscheduled plays.

Quarterback Matthew Stafford, the linchpin to the Rams’ aspirations for another Super Bowl appearance, emerged largely unscathed from a season-opening victory over the Houston Texans, but another great challenge awaits the offensive line Sunday against the Tennessee Titans.

Left guard Steve Avila is doubtful because of an ankle injury and right guard Kevin Dotson will be playing through an ankle issue.

Not great news for a group that must contain Titans defensive end Jeffery Simmons.

“He is really disruptive,” Stafford said of Simmons, who sacked Stafford three times in a Rams defeat in 2021, “gets off on the count, physical, fast and plays with a nasty streak.”

To reinforce the line and help establish the rushing attack, coach Sean McVay could deploy multiple tight ends.

The Rams’ defense faces quarterback Cam Ward, the top pick in the NFL draft.

Ward completed 12 of 28 passes for 112 yards in a 20-12 defeat by the Denver Broncos. He was sacked six times.

“He didn’t play bad last week,” Rams edge rusher Byron Young said. “He looked pretty comfortable back there even though he got sacked a few times. He was handling himself pretty well. … He knows what he’s doing. Even though he’s a rookie, he’s definitely somebody you can’t sleep on.”