The fan-favourite anchor, who fronts the early-morning show’s Thursday and Friday episodes with best pal Kate Garraway, 56, will bid farewell tomorrow, Friday.
It comes as Tipping Point frontman Ben, 49, was revealed as the new This Morning presenter with Cat Deeley.
On Thursday’s Good Morning Britain, Kate was talking about Coronation Street character Mary Taylor’s obsession with Ben.
In a recent ITV soap scene, aired on Valentine’s Day, Mary told how she would be “crying into my Ben Shephard cushion.”
Kate then quipped: “We are all going to be doing that tomorrow.
“At Good Morning Britain we are losing him.”
Later on, during the competition segment, Andi joked about getting him a present as he confirmed “it is Ben’s last day tomorrow.”
Fans will no doubt be devastated the pair’s on-screen banter will come to an end in just over 24 hours.
Ben has previously spoken out about how leaving his show “wife” was the “hardest decision.”