It had been eight years since the men’s national team last played in south Wales.
They got off to a worrying start, conceding a try inside five minutes and losing Antrobus in the process.
The York back row, recently returned from a serious ACL injury, hurt his knee as Jones-Bishop slipped through his tackle to score the opener.
Jamaica doubled their lead moments later when Kieran Rush’s kick eluded Mike Butt and Young pounced for the second try.
Sydney Roosters wing Young, brother of England’s Dom Young, was the only non-UK-based player in Jamaica’s team that included eight debutants.
Among the new Reggae Warriors were Huddersfield’s Darius Carter, Rochdale’s Jayden Dayes and York’s Isaac Coleman, a late replacement for James Woodburn-Hall.
Huddersfield’s Rush nudged Jamaica further ahead with a penalty late in the first half before Wales first steadied the ship and then struck back either side of half time.
Williams, extending his Welsh record with his 36th Test appearance, raced on to captain Elliot Kear’s kick before replacement Worthington crashed over from close range.
Sam Bowring also went close, while Jamaica lost playmaker Rush to injury early in the second half and lost their way.
Billy Walkley pulled off a stunning try-saving tackle to deny Carter with the scores level before his footwork and handling skills sparked the first of three Welsh tries in eight minutes.
Clarke, Dudson and Fozard all crossed from close range as Wales stuck to a basic gameplan, before a kind bounce gave Hudson-Lett a late try for the visitors.