Reece, Wayne Madsen and Anuj Dal are the only Derbyshire survivors from the 181-run win over Sussex in September 2019, three UK prime ministers ago and before Covid had struck the country.
It was a chastening comedown for the Welsh side, who had won seven out of eight One-Day Cup matches since the dramatic Championship tie against Gloucestershire at Cheltenham.
But Derbyshire were on the front foot almost throughout after Zak Chappell and Reece took six wickets in bowler-friendly conditions in the first hour.
The visitors’ hopes of survival virtually vanished when they lost three wickets without addition late on day three.
Resuming on 236-7, still 25 runs behind, Mason Crane and Dan Douthwaite battled hard in a stand of 47 before Lloyd made the breakthrough with the off-spin he has developed this season.
His first ball shot in almost unplayable fashion and Crane was lbw for 20, with Reece wrapping up the innings by having Fraser Sheat leg-before for 10 and bowling Douthwaite for 20 after a long vigil.
With rainclouds the only threat, Came hit two gentle deliveries from Glamorgan captain Sam Northeast to the boundary to seal the result to relieved applause from the long-suffering home crowd.