After Kevin Pillar got aboard with a one-out single to left, O’Hoppe hit a slider from Josh Hader (3-4) deep to left field. Trey Cabbage tried to make a play on it near the short wall, but appeared to drop it as he went halfway over the wall.

Mickey Moniak and Michael Stefanic each drove in two runs as the Angels avoided a series sweep.

Carlos Estévez (1-3) retired the Astros in the ninth to get the win.

Altuve also homered and drove in three runs. It was his first four-hit game this season and 39th of his career. His two-run homer during the sixth inning gave Houston a 7-4 lead before the Angels rallied.

Alex Bregman extended his hitting streak to 11 games with an RBI double in the third inning. He left the game in the bottom of the sixth after being hit in the left hand by Hunter Strickland’s sinker in the top of the inning.

The Angels took a 4-3 lead in the fifth on Willie Calhoun’s base hit that drove in Luis Rengifo. The advantage was short lived though as the Astros responded in the sixth.

Jose Abreu and Chas McCormick had RBI doubles before Altuve drove Hunter Strickland’s slider into the rockpile in left-center for a two-run shot to give the Astros a three-run lead.

Moniak’s base hit in the sixth drove in O’Hoppe to get the Angels within two runs before they tied it in the eighth.

Zach Neto had an RBI double, advanced to third on Ryan Pressley’s wild pitch and scored on Stefanic’s slow grounder to second to tie it at 7-all.

Up next for the Angels: Open a three-game series at Arizona on Tuesday. Left-hander José Suarez (1-0, 6.54 ERA) will make his first start of the season.