The Formula 1 veteran has taken part in 340 races but only ever peed himself once – during the Singapore Grand Prix a few years ago.
Drivers are often forced to relieve themselves during races after taking on plenty of fluid ahead of the race.
But Hamilton revealed he is often unable to pee himself, even if he feels discomfort from having a full bladder.
He said during an appearance on Hot Ones: “I just can’t bring myself to pee myself.
“I have once. It was Singapore, oh god. It was two or three years ago. Teh safety car came out and I was behind the safety car and I was like ‘I’m dying’.
“And honestly when your bladder is full, with the G-force you’re pulling it’s the most uncomfortable, it’s really really uncomfortable you just can’t focus on your job.
“I remember trying to go and I really had to force it. It’s really hard, but luckily I haven’t had to do it – only once.”
Hamilton said he often loses up to 500ml of fluid during a race – but still does not use his water bottle inside the car.
Other F1 drivers have admitted they have also peed themselves mid-race, including Red Bull star Sergio Perez.
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His team-mate Max Verstappen once said he came close, while Fernando Alonso has found himself in a similar position to Hamilton – wanting to pee but being unable to.
Hamilton once revealed Michael Schumacher regularly peed himself, saying: “The driver that used to drive for the team, was Michael Schumacher, I don’t know if anyone’s heard of him, but legend racing driver, but my mechanics told me he peed every single time he was in the car.”