Senior U.S. officials confirmed to multiple news agencies on Thursday that missiles were launched against Iran early Friday morning local time.

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There were additional explosions reported in Iraq and Syria, according to NPR.

However, a senior U.S. official did not confirm to ABC News if additional sites in Iraq and Syria were also hit.

Explosions were reportedly heard over the city of Isfahan – around 215 miles south of Tehran, per the Associated Press.

Around the same time, commercial flights were spotted changing routes over western Iran without providing an explanation.

Soon after, all flights to Tehran, Isfahan and Shiraz were suspended, CNN reported, citing the director of Iran’s public relations for an airport company.

Flights have reportedly not been officially canceled.

“Passengers should check the flight information before departure,” the director reportedly said.

The extent of damage from the reported strike, as well as the weapons used, was not immediately clear.

The alleged missile strike comes nearly one week after Iran unleashed an attack against Israel made up of over 300 ballistic missiles, cruise missiles and attack drones on Saturday.

Most of the missiles were intercepted or caused little damage to Israel.

Only one casualty was reported, with a seven year old Bedouin girl being hit by falling debris from an interceptor rocket in southern Israel.

At the time, Iran claimed the launch was in self-defense, claiming Israel killed seven of its Revolutionary Guards during a strike on the Iranian consulate in Damascus, Syria on April 1.

An Iranian commander was killed in the strike.

Israeli President Isaac Herzog has described the attack from Iran as a “declaration of war.”

Herzog claimed it is “time the world faces this empire of evil in Tehran” amid Western fears of an all-out war in the region.

Israel previously warned of an “imminent” retaliatory response to the weekend attack.

An IDF official said such an attack would be “coordinated with the Americans.”  

Iran’s Supreme National Security Council also vowed to retaliate against Israel if a counter-attack was launched.

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