Workers were forced to flee the factory, where atomic bombs are assembled, after the inferno scorched over 250,000 acres of land.
Eleven million people in the area are under an urgent “red flag warning” amid the strong winds and raging blaze.
The Pantex factory has been responsible for building and disassembling atomic bombs since 1975 – and last put one together in 1991.
Pantex officials said a “small number” of non-essential staff are still sheltering inside and plant operations have been paused until further notice.
They also said that “all weapons and special materials are safe and unaffected”.
The nuclear factory is about 30 miles from the city of Amarillo.
Residents in several towns in Texas have been forced to flee their homes amid the Smokehouse Creek Fire – which is 0% contained according to local officials.
The Grape Vine Creek Fire and Windy Deuce Fire, all part of the same threat, are ploughing their way through other parts of the state.
Gusts of up to 65mph are fanning the inferno – which isn’t expected to be contained soon, the National Weather Service said.
They said “Stronger winds are anticipated today, and conditions will remain quite favourable for the start and spread of wildfires.”
And on Tuesday evening they added: “Critical fire weather conditions continue through this evening across all of the Oklahoma and Texas Panhandles due to strong west winds.”
And Gregg Abbott, the Texas governor, declared it a disaster situation for 60 different countries across the region.
The Texas A&M Forest Service had to jump on over a dozen different wildfires for just over 77,000 acres on Monday.
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