The Red Devils travelled to Stateside last summer to face Arsenal, Wrexham, Real Madrid and Borussia Dortmund in preparation for the 2023-24 campaign.
They won two and lost two games while in the USA before returning to England ahead of the Premier League kick-off.
But the trip was deemed so successful that club chiefs have organised a return.
United will face Arsenal once again this summer, this time in Los Angeles.
The match will take place at the 70,000-capacity SoFi stadium on July 27.
Erik ten Hag and his players will then travel to Columbia, South Carolina, to face Liverpool on August 3.
That game will take place at the University of South Carolina’s William Brice Stadium.
It will be the first time the two sides have met in the US since 2018, when they played in front of 101,000 fans at the Michigan Stadium.
Liverpool and Arsenal will also come up against each other on July 31 in Philadelphia.
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It will be the Reds’ first pre-season without Klopp nine years.
Xabi Alonso is understood to be Liverpool’s top managerial target ahead of the summer, with Roberto De Zerbi also high on the shortlist.
Ange Postecoglou and Ruben Amorim have also been linked with the job.
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