Poch freshens up frontline
It’s two changes for Mauricio Pochettino following that late success at Crystal Palace on Monday night.
Raheem Sterling is back in the side to face his former club, replacing Noni Madueke, who drops to the bench.
Thiago Silva has not been able to shake off the injury he picked up at Selhurst Park, and so Levi Colwill comes into defence. Ben Chilwell captains the visitors.
Ruthless City take attacking shape
Pep Guardiola makes three changes following Champions League victory in Copenhagen on Tuesday.
Jack Grealish picked up an injury in Denmark, and so is replaced on the left by Jeremy Doku while Bernardo Silva makes way for Julian Alvarez.
At the back, John Stones drops out in favour for Manuel Akanji in a move that sees Nathan Ake shift back into the centre.
Poch hopes to emulate Special One
Chelsea boss Mauricio Pochettino may have lost more matches against Pep Guardiola (13) than he has any other manager.
However, his four wins against the Spanish coach have been with three different clubs (Espanyol, Spurs twice and PSG).
The only manager to have beaten Guardiola with four different clubs is one Jose Mourinho, who got the better of Pep with Inter Milan, Real Madrid, Man Utd and Tottenham.
Jackson up top for Blues
Chelsea (4-2-3-1): 28 Petrovic; 27 Gusto, 2 Disasi, 26 Colwill, 21 Chilwell; 25 Caicedo, 8 Fernandez; 20 Palmer, 23 Gallagher, 7 Sterling; 15 Jackson
Subs: 13 Bettinelli, 10 Mudryk, 11 Madueke, 14 Chalobah, 18 Nkunku, 31 Casadei, 42 Gilchrist, 53 Samuels-Smith, 79 Harrison
Haaland and De Bruyne start for City
Man City (4-1-4-1): 31 Emerson; 2 Walker, 3 Dias, 6 Are, 25 Akanji; 16 Rodri; 47 Foden, 17 De Bruyne, 19 Alvarez, 11 Doku; 9 Haaland
Subs: 18 Ortega, 5 Stones, 8 Kovacic, 20 Silva, 21 Gomez, 27 Nunes, 52 Bobb, 76 Susoho, 82 Lewis
Takes two for new record
Manchester City and Chelsea memorably played out a thrilling 4-4 draw in the reverse fixture at Stamford Bridge back in a November.
And many will be tuning in tonight, hoping for another goalscoring feat in the return.
If there are just two netted at the Etihad, it would set a new record when it comes to meetings between these two.
Until now, the most goals scored in games between them in a single Premier League season is nine back in 2009-10 when City won 2-1 at home and 4-2 away.