Five teens aged 14 to 16 were rushed to hospital in Eltham, south east London after puffing on a vape laced with the drug Spice.
One of the youngsters was put into an induced coma after the group suffered a reduced level of consciousness, vomiting and confusion.
All five teens are thought to have recovered since emergency services were called on January 29, the Mirror reports.
They had reportedly used a rechargeable vape pen containing blue liquid in a silver and black cartridge labelled Vaporesso.
It comes after two young people were taken ill after using a Spice-laced vape in Merton, south west London.
The pair may not have know that the vape, labelled Lemonade Vape Cookies, contained Spice.
Lab-made drug Spice was designed to mimic the effects of cannabis, but can have very different effects.
Symptoms include dizziness, breathing difficulties, chest pain, heart palpitations, seizures, temporary paralysis.
The drug has also been linked to paranoia, suicidal thoughts, psychosis and acute kidney injuries.
Cops fear that Spice is now sweeping schools across the UK after reports of kids collapsing in Middlesbrough, Yorkshire and Wales.
Pupils as young as 12 were found to be using Spice-laced vapes in Selby, North Yorkshire.
A government spokesperson said: “Marketing vapes to children is unacceptable.
“We are cracking down on this by banning disposable vapes, restricting their flavours, and changing how and where they are displayed in shops.”