Pili shot 13 of 16 from the field, including five of six on three-pointers. Matyson Wilke added 12 points off the bench.
JuJu Watkins led USC with 24 points and McKenzie Forbes added 11. The Trojans (13-2, 3-2 Pac-12) struggled on offense, shooting 36% from the field and going seven of 14 from the free-throw line.
Issy Palmer returned to action for Utah (13-5, 3-3) for the first time since being sidelined in mid-November with a knee injury. Palmer started at point guard for the first three games before getting injured in a loss to Baylor.
The Utes overtook USC in the first quarter with stifling defense, holding the Trojans to just 31% shooting over the opening 10 minutes. Pili scored four of Utah’s first five second-quarter baskets, culminating in a three-pointer and a layup off a steal that put the Utes up 32-20 midway through the quarter.
Watkins scored a pair of baskets to fuel a 10-2 USC run that trimmed Utah’s lead to 41-38 early in the third quarter. The Trojans were unable to erase the deficit entirely. Pili scored three baskets to help the Utes end the third quarter on a 14-2 run. She punctuated the run with a three-pointer that gave Utah a 61-44 lead heading into the fourth quarter.
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USC struggled to keep the Utes from successfully attacking the rim. The Trojans were outscored 28-14 in the paint.
Utah maximized scoring opportunities on possessions following turnovers. The Utes turned 17 USC turnovers into 27 points, opening a door for them to pull away after halftime.
Up next for USC: visits Colorado on Sunday.