No injuries or damage reported in what the US military said was the 26th attack by the Yemen-based group since November 19.
Working with forces from the United Kingdom, CENTCOM said two anti-ship cruise missiles and one anti-ship ballistic missile were also brought down.
“Iranian-backed Huthis launched a complex attack of Iranian designed one-way attack UAVs… anti-ship cruise missiles, and an anti-ship ballistic missile from Huthi-controlled areas of Yemen into the Southern Red Sea,” the US Central Command (CENTCOM) said in a statement on Wednesday.
The attack was the 26th by the Houthis on shipping lanes in the Red Sea since November 19 when it hijacked the Galaxy Leader, a vehicle carrier that was on its way from Turkey to India.
The Iran-aligned group said it began the attacks in protest at Israel’s war on Gaza.
CENTCOM said fighter jets from the Dwight D Eisenhower aircraft carrier and four destroyers, including one from the UK, took part in the operation.
No injuries or damage were reported.
The US last month formed an international maritime coalition to deal with the attacks, which have prompted some shipping lines to take the longer sea route around southern Africa and avoid the Red Sea altogether.
The Houthis have said they will continue their attacks until Israel halts the conflict in Gaza.
CENTCOM said US forces shot down a drone launched from Yemen over the weekend, while Vice Admiral Brad Cooper, the commander of US naval forces in the Middle East, said the Houthis had launched an explosives-laden sea drone into shipping lanes last week – the first time they had used such a weapon in the current conflict.
The Houthis say they are targeting Israeli-linked vessels but Cooper said dozens of countries have connections to ships that have been attacked.
At the time of its hijack, the Galaxy Leader – although ultimately owned by a firm linked to an Israeli businessman – was being operated by the Japanese shipping line NYK and most of its 25-strong crew were from the Philippines. Other vessels have had no discernible links to Israel.
The war in Gaza erupted on October 7 when armed group Hamas carried out a shock cross-border attack and killed 1,139 people in Israel.
At least 23,210 people have been killed in Gaza since Israel began its assault hours later.