Lamar Jackson threw two touchdown passes in a span of 18 seconds in the third quarter and the Baltimore Ravens intercepted Brock Purdy four times in a 33-19 victory over the San Francisco 49ers on Monday night.

Jackson and the Ravens (12-3) turned a highly anticipated match-up between the top two teams in the NFL into a lopsided win with strong performances on both sides of the ball.

Kyle Hamilton and the defence set the tone early by intercepting Purdy on three of the first four drives of the game for the 49ers (11-4) before Jackson started to take over the game.

He scrambled 30 yards to set up a field goal on the final play of the first half to give the Ravens a 16-12 lead and then helped put the game away early in the third quarter.

After Baltimore forced a punt on the opening drive of the second half, Jackson capped a drive by throwing a 6-yard touchdown pass to Nelson Agholor.

Purdy then was intercepted by Patrick Queen on the next play from scrimmage. Jackson immediately turned that into another score with a 9-yard TD pass to Zay Flowers that made it 30-12.

Jackson threw for 252 yards, ran for 45 more and vaulted past Purdy to become the MVP favourite, according to FanDuel Sportsbook. His only real mishap came when he got called for intentional grounding in the end zone after nearly tripping over the umpire, leading to a safety in the first quarter.

Purdy had his roughest game as a pro, becoming the first 49ers quarterback to throw four interceptions in a game since Colin Kaepernick in 2015, adding a few more near interceptions and being unable to generate the big plays that made him the league’s most efficient quarterback coming into the game.