The bumper 48 hours of savings begins at midnight on October 10 and will see prices on top products slashed by as much as 60%.
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The discount period, dubbed Prime Big Deal Days, is the third offered by the online retail giant within a year and allows customers to chase deals on major brands.
Amazon is saying that this edition will include the “lowest prices of the year” on offerings from Barbie, Samsung and Sony among others, while also coughing up price cuts on Bose, Oral-B and Fitbit.
Now, the consumer gurus from Money Saving Expert have listed some of the top savings available.
For example, the Amazon Echo Pop has seen a 60% cut from £44.99 to £17.99.
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Likewise, the Ring video doorbell has gone from £99.99 to £59.99.
From Bose, the QuietComfort 45 noise-cancelling headphones have seen a major drop from £319 to £178.95, while the Shark WandVac 2.0 is expected to match its previous Prime Day price of £99.99.
Perhaps best of all, the Fitbit Versa 4, which at its old price of £168 was already below the RRP of £199.99, has been reduced by a further £23 to £144.99.
Shoppers can access these special offers through the Amazon Deals page on the website.
Just make sure to catch them in time as some are only active for a limited time.
The experts also predicted more deals would soon be announced on products from Apple, Lego, Ninja, SodaStream and Rimmel based on last year’s sale.
However, customers were warned to watch out for dud deals as not all the products on offer will be reduced.
Oli Townsend from MSE said: “While there are strong deals, there are also some duds.
“For example, during Prime Day in July we spotted the Fire TV stick 4K was £35, but we’d seen it previously for £30 or less on a few occasions.
“An Oral-B electric toothbrush was £40 in the sale, only 1p cheaper than the day before, and was cheaper at £35 previously.”
It comes after The Sun’s own James Flanders tested fresh supermarket pizzas to see which was the best value, and revealed how it could save him £676 a year.
Meanwhile, a Christmas favourite faces a major shortage after a supply crisis.
MSE’s top tips for Prime Big Deal Days
1. Only buy what you need and check current prices now
2. Amazon is not always cheapest so use comparison tools
3. Use a price tracker to see if the deal is a dud
4. Look out for price-matching from other retailers
5. Check if you can save even more via Amazon Warehouse, which sells returned or mildly damaged items