The former Premier League official took charge of the much-anticipated game for a second year on the bounce.
The match being for charity did not mean that Clattenburg, 48, left his cards at home.
With the Sidemen 6-4 up against the YouTube All-Stars in the 78th minute, Max Fosh fouled Simon Minter.
Clattenburg promptly went over to caution Fosh.
The whistler got his yellow card out… only to be Uno reversed.
Fosh, 28, cheekily pulled out an Uno reverse card of his own, with Clattenburg subsequently withdrawing his booking.
The match was watched by a capacity 60,000 crowd at the London Stadium.
And a further 2.5million people tuned in at home on YouTube.
Many of the hordes watching loved Fosh’s unique moment.
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Accompanied by a laughing emoji, one fan wrote: “My man Fosh uno reversed Clattenburg.”
While a second joked: “Can’t believe Premier League players never tried this.”
A third quipped: “Max Fosh just Uno-Reversed Mark Clattenburg for a yellow card and it worked, what am I watching.”
Another added: “No way Max Fosh has just Uno Reversed Mark Clattenburg.”
The Sidemen triumphed 8-5 in the dramatic match in East London.
A huge amount of money was raised for Campaign Against Living Miserably (CALM), youth charity Teenage Cancer Trust and wish-granting charity, Rays of Sunshine.
Within just two hours, the game had raised £2.4million for various good causes.