Yorke, 51, considers Maguire’s exit from the Red Devils as a “no-brainer”.
The England defender has endured a particularly difficult two years that have seen him come under intense scrutiny.
Maguire – who was recently displaced by Bruno Fernandes as club captain – has been ridiculed by his own fans and dropped by United boss Erik ten Hag.
Yet Maguire seems like he could stay at Old Trafford , with his £30m move to West Ham being called-off just days ago.
But United hero Yorke has publicly told Maguire it is time to sought out a new club.
The 1999 Treble-winning icon told OLBG: “I don’t think Harry Maguire will be an option for squad depth now.
“Not when he’s been humiliated by the manager who spoke publicly about fighting for his place.
“It’s about being the best in your position at the club, that’s what he needs to aim for, his confidence will be low after his captaincy was taken away.
“Imagine seeing Luke Shaw playing in your position and you’re still on the bench, imagine what that would do to your confidence”.
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Yorke then went on to discuss the damage it would have done to his standing in the United dressing room.
He added: “Maguire might see it differently and he’s entitled to, but I think him leaving Man United is a no-brainer.
“His respect in the changing room would have diminished, he would have been embarrassed by what’s happened in recent weeks.”
For much of the summer, it has seemed likely that the ex-Leicester centre-back would leave amid intense interest from West Ham.
However, any potential move to East London has since fallen through.
The Hammers reached an agreement with United for a £30m fee, but have failed to agree personal terms with Maguire.
West Ham grew so frustrated with waiting for Maguire to secure a pay-out from United that they have now walked away from negotiations.
The defender told United that he wanted £15m, as he’d have to surrender his £190,000-a-week contract, which has two years left, for a reduced £120,000 in weekly wages.
The Red Devils had already offered him a £6m sum to leave.
The report does state, though, the collapsed deal could still be revived – but in the meantime West Ham are looking at alternative centre-back options.
Ten Hag is not disheartened by Maguire’s reluctance to leave and in fact thinks the 30-year-old could still “fight for his place”.
Maguire may need to play more frequently to cement his place in England’s squad for next year’s Euros.
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