The No2 seed, vying for an eighth title at the All England Club, was a set and a break up at the time.
Djokovic thumped a backhand down the line but let out an almighty grunt.
However, British umpire Richard Haigh deemed the shriek to be too late and off-putting to Italian ace Sinner.
Haigh immediately called “hindrance”, leaving Djokovic gobsmacked.
The Serbian superstar slumped to his knees in absolute disbelief.
And John McEnroe, another Wimbledon legend, was left stunned at the decision.
Speaking on ESPN, the US hothead said: “That’s absurd – that’s crazy.
“That’s just a horrible call.”
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