The Gunners squandered a two-goal lead and two crucial points in their last fixture against West Ham.
However, Mikel Arteta will be expecting his side to bounce back against relegation-threatened Saints who are rock bottom of the division.
- Kick-off time: 8pm BST
- Live stream: NOW TV
- TV channel: Sky Sports Main Event and Premier League
- Arsenal XI: To follow
- Southampton XI: To follow
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Arsenal starting line-up
Aaron Ramsdale starts in goal with Ben White, Rob Holding, Gabriel Magalhaes and Oleksandr Zinchenko in defence.
Fabio Vieira replaces Granit Xhaka in midfield. He starts alongside Thomas Partey with Martin Odegaard in attacking midfield.
Bukayo Saka, Gabriel Jesus and Gabriel Martinelli form the front three.
Credit: Twitter / @Arsenal -
BREAKING: Xhaka unavailable due to illness
Granit Xhaka is not available for tonight’s game due to illness, according to reports.
The midfielder was not seen with the Arsenal squad earlier today.
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The Emirates awaits
Arsenal have arrived at the Emirates for today’s game.
Credit: Reuters 
Credit: Getty
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Southampton team news
Ainsley Maitland-Niles will not be available as he is ineligible to play against his parent club.
Juan Larios, Valentino Livramento, Mislav Orsic and Mohammed Salisu are all unavailable due to injury.
Che Adams could return to action following a brief spell on the sidelines with a calf issue.
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Arsenal team news
William Saliba remains out of action with a back injury, so Rob Holding will likely start in defence.
Oleksandr Zinchenko was spotted with the Arsenal squad this morning, so he will likely return to the starting line-up or the bench following his brief spell on the sidelines with a groin injury.
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Welcome to Arsenal vs Southampton
Good evening and welcome to SunSport’s coverage of Arsenal vs Southampton.
The 2022-23 season is nearing a close and both teams still have something huge to fight for.
The Gunners are seeking their first league title in 19 years while the Saints are battling for Prem survival.
A huge 90 minutes awaits!