Ohtani (1-0) kept the Mariners scoreless after allowing a run in a bumpy first inning, finishing his day having allowed three hits and four walks while striking out eight.

Ohtani drove in Taylor Ward with a single in the top of the seventh against Mariners reliever Andrés Muñoz to put the Angels lead 4-1.

After Julio Rodriguez scored in the bottom of the first to give Seattle the early lead, Logan O’Hoppe hit a two-run homer against Mariners starter Chris Flexen (0-1) to put the Angels on top 2-1.

Ohtani and Mike Trout both drove in runs off Munoz in the seventh, but the Mariners pulled within one run in the bottom half of the inning as Ty France and Eugenio Suarez drove in runs.

José Quijada pitched the ninth for his first save.

The Mariners finished the night with eight hits, while the Angels had five in the series-clinching victory.