Ohtani drove a 1-1 pitch from George Kirby (0-1) an estimated 431 feet into the right-center-field seats in the fifth inning for a 4-2 lead. Ohtani had grounded out in his first two at-bats before the rare home run off Kirby, who surrendered only one long ball during the final three months of last season.

Ward’s homer came off Matt Festa with two outs and after Luis Rengifo had walked on a couple of borderline pitches. Rengifo also was a problem for Seattle with a pair of RBI singles earlier in the game, both scoring Jake Lamb.

Rengifo wasn’t in the original starting lineup but was inserted after Anthony Rendon dropped the appeal of his suspension for an incident last week in Oakland and started serving his four-game punishment Monday.

Mike Trout was also on base five times with a single, three walks and a hit by pitch.

After losing on opening night, the Angels have won three straight while the Mariners have dropped four in a row after winning their opener.

Eugenio Suárez had an RBI double in the first inning and his RBI single in the fifth pulled Seattle within 4-3. Ty France also had an RBI double for Seattle and stole the first base of his career when he swiped third base in the third inning. Among active players, France had the second-most times on base without a steal and he hadn’t attempted a stolen base since his rookie season of 2019.

Angels starter Reid Detmers was one out shy of getting through the fifth inning and qualifying for the victory. Ryan Tepera (1-0) recorded the final out of the fifth inning to get the victory.