The Friends favourite made his appearance on the Channel 4 show tonight alongside Little Mix star Jesy Nelson and comedians Rose Matafeo and Tom Davis.
David, 56, originally rose to fame as iconic character Ross Geller 28 years ago on the iconic comedy show.
However, the star has now turned his attention away from acting in order to try out a new skill in order to raise funds for the Stand Up to Cancer charity.
Paying homage to his comedy routes, David appeared in an opening comedy sketch with show host Matt Lucas where he joked that he had only showed up for the ‘big money’ promised on his invite.
Matt then informed David that it was actually referring to the ‘big money’ to be raised for charity as opposed to a potential pay cheque for the Hollywood actor.
Fans were left going wild online at the Hollywood icon’s appearance on the classic British TV favourite.
One fan excitedly declared: “I’m bl**dy loving David Schwimmer on this show what a legend he is.”