Pep Guardiola’s City can leap back to the summit with three points, while the Gunners can extend their lead to a stunning six points with a win at the Emirates.
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City’s trip to Arsenal was originally scheduled for October but was postponed to accommodate the North London club’s previous called-off Europa League clash with PSV Eindhoven.
The Gunners were scheduled to play PSV on Thursday, September 15 but the match got postponed due to concerns over police resources following the passing of Queen Elizabeth II the previous week.
And now it takes place with the stakes even HIGHER than before.
The Gunners have a torrid recent record against City, having not defeated them in the league since December 2015.
Arsenal vs Man City – latest odds and betting offers
What live stream and TV channel is Arsenal vs Man City on?
Arsenal vs Man City will be broadcast on Amazon Prime Video.
The game has been rescheduled from its initial October date.
Amazon get their coverage underway from 6.30pm with a full hour of build up.
How can I watch Arsenal vs Man City FREE?
Non-Prime members can start a 30-day free trial of Prime (£8.99/month or £95/year), or our Prime Video subscription (£5.99/month).
You can cancel before the end of the trial before it moves into a full subscription.
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Who is on punditry tonight?
Simon Thomas is joined by Alan Shearer, Eni Aluko, Gael Clichy and Roberto Martinez, live from the Emirates Stadium.
While commentary comes from Clive Tyldesley and Ally McCoist.